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Deubiquitylating enzymes and drug discovery: emerging opportunities

Nature reviews. Drug discovery, 2018-01, Vol.17 (1), p.57-78

2018

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Nature, 2005-04, Vol.434 (7035), p.917-921

2005

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Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (5), p.1212-1216

2013

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Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer

Molecular cancer therapeutics, 2013-06, Vol.12 (6), p.959-967

2013

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High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

Proceedings of the National Academy of Sciences - PNAS, 2008-11, Vol.105 (44), p.17079-17084

2008

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

Cancer research (Chicago, Ill.), 2004-12, Vol.64 (24), p.9152-9159

2004

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Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors

Cancer discovery, 2013-01, Vol.3 (1), p.68-81

2013

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Deubiquitylating Enzymes and DNA Damage Response Pathways

Cell biochemistry and biophysics, 2013-09, Vol.67 (1), p.25-43

2013

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4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1

Journal of medicinal chemistry, 2008-10, Vol.51 (20), p.6581-6591

2008

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Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K

Molecular cancer therapeutics, 2012-08, Vol.11 (8), p.1789-1798

2012

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The Replaceability Paradigm: Replacement and Irreplaceability from Dante to DeepDream

1, 2024

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How Well Do We Know the Future of CO2 Emissions? Projecting Fleet Emissions from Light Duty Vehicle Technology Drivers

Environmental science & technology, 2017-03, Vol.51 (5), p.3093-3101

2017

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Selective Inhibition of BRCA2-Deficient Mammary Tumor Cell Growth by AZD2281 and Cisplatin

Clinical cancer research, 2008-06, Vol.14 (12), p.3916-3925

2008

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The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models

Cancer research (Chicago, Ill.), 2016-10, Vol.76 (20), p.6084-6094

2016

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Cost-effectiveness of alternative powertrains for reduced energy use and CO2 emissions in passenger vehicles

Applied energy, 2014-07, Vol.124, p.44-61

2014

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Poly(ADP-Ribose) Polymerase-1 Inhibitor Treatment Regresses Autochthonous Brca2/p53-Mutant Mammary Tumors In vivo and Delays Tumor Relapse in Combination with Carboplatin

Cancer research (Chicago, Ill.), 2009-05, Vol.69 (9), p.3850-3855

2009

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Indicators of intentional scald injury—A survey of UK burn consultants

Burns, 2021-09, Vol.47 (6), p.1464-1465

2021

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Iain Sinclair: Noise, Neoliberalism and the Matter of London

Martin, Niall

1, 2015

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Can UK passenger vehicles be designed to meet 2020 emissions targets? A novel methodology to forecast fuel consumption with uncertainty analysis

Applied energy, 2015-11, Vol.157, p.929-939

2015

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Accurately identifying blast injuries in civilian burn practice

Burns, 2018-09, Vol.44 (6), p.1610-1611

2018

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Quantifying the role of vehicle size, powertrain technology, activity and consumer behaviour on new UK passenger vehicle fleet energy use and emissions under different policy objectives

Applied energy, 2016-10, Vol.180, p.196-212

2016

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Lack of precision of burn surface area calculation by UK Armed Forces medical personnel

Burns, 2014-03, Vol.40 (2), p.246-250

2014

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Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (20), p.5898-5901

2009

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5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2)

Journal of medicinal chemistry, 2011-04, Vol.54 (7), p.2049-2059

2011

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BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly (ADP-ribose) polymerase: An issue of potency

Cancer biology & therapy, 2005-09, Vol.4 (9), p.934-936

2005

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Deubiquitylating enzymes and drug discovery: emerging opportunities

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors

Deubiquitylating Enzymes and DNA Damage Response Pathways

4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1

Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K

The Replaceability Paradigm: Replacement and Irreplaceability from Dante to DeepDream

How Well Do We Know the Future of CO2 Emissions? Projecting Fleet Emissions from Light Duty Vehicle Technology Drivers

Selective Inhibition of BRCA2-Deficient Mammary Tumor Cell Growth by AZD2281 and Cisplatin

The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models

Cost-effectiveness of alternative powertrains for reduced energy use and CO2 emissions in passenger vehicles

Poly(ADP-Ribose) Polymerase-1 Inhibitor Treatment Regresses Autochthonous Brca2/p53-Mutant Mammary Tumors In vivo and Delays Tumor Relapse in Combination with Carboplatin

Indicators of intentional scald injury—A survey of UK burn consultants

Iain Sinclair: Noise, Neoliberalism and the Matter of London

Can UK passenger vehicles be designed to meet 2020 emissions targets? A novel methodology to forecast fuel consumption with uncertainty analysis

Accurately identifying blast injuries in civilian burn practice

Quantifying the role of vehicle size, powertrain technology, activity and consumer behaviour on new UK passenger vehicle fleet energy use and emissions under different policy objectives

Lack of precision of burn surface area calculation by UK Armed Forces medical personnel

Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR

5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2)

BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly (ADP-ribose) polymerase: An issue of potency

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