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An Artificial Heme Enzyme for Cyclopropanation Reactions

Angewandte Chemie International Edition, 2018-06, Vol.57 (26), p.7785-7789

International ed. in English, 2018

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Directed Evolution of a Designer Enzyme Featuring an Unnatural Catalytic Amino Acid

Angewandte Chemie International Edition, 2019-02, Vol.58 (7), p.2083-2087

International ed. in English, 2019

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Gene Fusion and Directed Evolution to Break Structural Symmetry and Boost Catalysis by an Oligomeric C−C Bond‐Forming Enzyme

Angewandte Chemie International Edition, 2022-02, Vol.61 (8), p.e202113970-n/a

International ed. in English, 2022

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Engineered C–N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners

Angewandte Chemie International Edition, 2020-01, Vol.59 (1), p.429-435

International ed. in English, 2020

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Subunit and chlorophyll organization of the plant photosystem II supercomplex

Nature plants, 2017-06, Vol.3 (7), p.17080, Article 17080

2017

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Structural basis of steroid binding and oxidation by the cytochrome P450 CYP109E1 from Bacillus megaterium

The FEBS journal, 2016-11, Vol.283 (22), p.4128-4148

2016

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Regio- and stereoselective steroid hydroxylation by CYP109A2 from Bacillus megaterium explored by X-ray crystallography and computational modeling

The FEBS journal, 2023-10, Vol.290 (20), p.5016-5035

2023

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Using Mutability Landscapes To Guide Enzyme Thermostabilization

Chembiochem : a European journal of chemical biology, 2021-01, Vol.22 (1), p.170-175

2021

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The Role of Tryptophan in π Interactions in Proteins: An Experimental Approach

Journal of the American Chemical Society, 2022-08, Vol.144 (30), p.13815-13822

2022

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Robust ω‑Transaminases by Computational Stabilization of the Subunit Interface

ACS catalysis, 2020-03, Vol.10 (5), p.2915-2928

2020

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Cofactor Binding Dynamics Influence the Catalytic Activity and Selectivity of an Artificial Metalloenzyme

ACS catalysis, 2020-10, Vol.10 (20), p.11783-11790

2020

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Enantioselective Synthesis of Pharmaceutically Active γ‑Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions

ACS catalysis, 2019-02, Vol.9 (2), p.1503-1513

2019

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Boron catalysis in a designer enzyme

Nature (London), 2024-05, Vol.629 (8013), p.824-829

2024

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Evidence for the Formation of an Enamine Species during Aldol and Michael-type Addition Reactions Promiscuously Catalyzed by 4-Oxalocrotonate Tautomerase

Chembiochem : a European journal of chemical biology, 2015-03, Vol.16 (5), p.738-741

2015

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Biochemical and structural characterization of CYP109A2, a vitamin D3 25‐hydroxylase from Bacillus megaterium

The FEBS journal, 2017-11, Vol.284 (22), p.3881-3894

2017

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Unlocking Asymmetric Michael Additions in an Archetypical Class I Aldolase by Directed Evolution

ACS catalysis, 2021-11, Vol.11 (21), p.13236-13243

2021

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Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases

Nature communications, 2016-03, Vol.7 (1), p.10911-10911, Article 10911

2016

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Structure of the transcriptional regulator LmrR and its mechanism of multidrug recognition

The EMBO journal, 2009-01, Vol.28 (2), p.156-166

2009

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Structural Basis for the Catalytic Mechanism of Ethylenediamine‑N,N′‑disuccinic Acid Lyase, a Carbon–Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope

Biochemistry (Easton), 2018-07, Vol.57 (26), p.3752-3763

2018

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On the Mechanism of Peptidoglycan Binding and Cleavage by the endo-Specific Lytic Transglycosylase MltE from Escherichia coli

Biochemistry (Easton), 2012-11, Vol.51 (45), p.9164-9177

2012

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Computational Redesign of an ω‑Transaminase from Pseudomonas jessenii for Asymmetric Synthesis of Enantiopure Bulky Amines

ACS catalysis, 2021-09, Vol.11 (17), p.10733-10747

2021

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Explaining Operational Instability of Amine Transaminases: Substrate-Induced Inactivation Mechanism and Influence of Quaternary Structure on Enzyme–Cofactor Intermediate Stability

ACS catalysis, 2017-02, Vol.7 (2), p.1259-1269

2017

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Structure-Based Engineering of Steroidogenic CYP260A1 for Stereo- and Regioselective Hydroxylation of Progesterone

ACS chemical biology, 2018-04, Vol.13 (4), p.1021-1028

2018

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Functional Characterization of Mutations in the Myosin Vb Gene Associated With Microvillus Inclusion Disease

Journal of pediatric gastroenterology and nutrition, 2011-03, Vol.52 (3), p.307-313

2011

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Aspartase/Fumarase Superfamily: A Common Catalytic Strategy Involving General Base-Catalyzed Formation of a Highly Stabilized aci -Carboxylate Intermediate

Biochemistry (Easton), 2012-05, Vol.51 (21), p.4237-4243

2012

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An Artificial Heme Enzyme for Cyclopropanation Reactions

Directed Evolution of a Designer Enzyme Featuring an Unnatural Catalytic Amino Acid

Gene Fusion and Directed Evolution to Break Structural Symmetry and Boost Catalysis by an Oligomeric C−C Bond‐Forming Enzyme

Engineered C–N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners

Subunit and chlorophyll organization of the plant photosystem II supercomplex

Structural basis of steroid binding and oxidation by the cytochrome P450 CYP109E1 from Bacillus megaterium

Regio- and stereoselective steroid hydroxylation by CYP109A2 from Bacillus megaterium explored by X-ray crystallography and computational modeling

Using Mutability Landscapes To Guide Enzyme Thermostabilization

The Role of Tryptophan in π Interactions in Proteins: An Experimental Approach

Robust ω‑Transaminases by Computational Stabilization of the Subunit Interface

Cofactor Binding Dynamics Influence the Catalytic Activity and Selectivity of an Artificial Metalloenzyme

Enantioselective Synthesis of Pharmaceutically Active γ‑Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions

Boron catalysis in a designer enzyme

Evidence for the Formation of an Enamine Species during Aldol and Michael-type Addition Reactions Promiscuously Catalyzed by 4-Oxalocrotonate Tautomerase

Biochemical and structural characterization of CYP109A2, a vitamin D3 25‐hydroxylase from Bacillus megaterium

Unlocking Asymmetric Michael Additions in an Archetypical Class I Aldolase by Directed Evolution

Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases

Structure of the transcriptional regulator LmrR and its mechanism of multidrug recognition

Structural Basis for the Catalytic Mechanism of Ethylenediamine‑N,N′‑disuccinic Acid Lyase, a Carbon–Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope

On the Mechanism of Peptidoglycan Binding and Cleavage by the endo-Specific Lytic Transglycosylase MltE from Escherichia coli

Computational Redesign of an ω‑Transaminase from Pseudomonas jessenii for Asymmetric Synthesis of Enantiopure Bulky Amines

Explaining Operational Instability of Amine Transaminases: Substrate-Induced Inactivation Mechanism and Influence of Quaternary Structure on Enzyme–Cofactor Intermediate Stability

Structure-Based Engineering of Steroidogenic CYP260A1 for Stereo- and Regioselective Hydroxylation of Progesterone

Functional Characterization of Mutations in the Myosin Vb Gene Associated With Microvillus Inclusion Disease

Aspartase/Fumarase Superfamily: A Common Catalytic Strategy Involving General Base-Catalyzed Formation of a Highly Stabilized aci -Carboxylate Intermediate

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