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Translocation of a gut pathobiont drives autoimmunity in mice and humans

Science (American Association for the Advancement of Science), 2018-03, Vol.359 (6380), p.1156-1161

2018

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564 Preclinical rationale for a first-in-human trial to evaluate the safety and preliminary efficacy of desmoglein 3 chimeric autoantibody receptor T cells (DSG3-CAART) for mucosal pemphigus vulgaris

Journal of investigative dermatology, 2020-07, Vol.140 (7), p.S77-S77

2020

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A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity

Cell host & microbe, 2019-01, Vol.25 (1), p.113-127.e6

2019

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Mechanisms and consequences of gut commensal translocation in chronic diseases

Gut microbes, 2020-03, Vol.11 (2), p.217-230

2020

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Bruton’s Tyrosine Kinase Inhibition in Pemphigus: An Embattled Frontier

Journal of investigative dermatology, 2024-08, Vol.144 (8), p.1667-1670

2024

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Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris

The Journal of clinical investigation, 2020-12, Vol.130 (12), p.6317-6324

2020

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Nature of the multicomponent crystal of salicylic acid and 1,2-phenylenediamine

CrystEngComm, 2020, Vol.22 (4), p.78-719

2020

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Chimeric Autoantibody Receptor (CAAR) T Cells as a Precision Therapy for Antigen-Specific B Cell Depletion in PLA2R Membranous Nephropathy: FR-OR32

Journal of the American Society of Nephrology, 2021-10, Vol.32 (10S), p.30-30

2021

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Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity

Cell host & microbe, 2019-07, Vol.26 (1), p.100-113.e8

2019

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Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells

Nature biotechnology, 2023-09, Vol.41 (9), p.1229-1238

2023

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Regulation of type 17 helper T-cell function by nitric oxide during inflammation

Proceedings of the National Academy of Sciences - PNAS, 2011-05, Vol.108 (22), p.9220-9225

2011

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T cell and bacterial microbiota interaction at intestinal and skin epithelial interfaces

Discovery immunology, 2023, Vol.2 (1), p.kyad024-kyad024

2023

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Identification of Organelles in Bacteria Similar to Acidocalcisomes of Unicellular Eukaryotes

The Journal of biological chemistry, 2003-08, Vol.278 (32), p.29971-29978

2003

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Gut pathobiont translocation induces lymphocyte migration to internal organs in autoimmunity

The Journal of immunology (1950), 2018-05, Vol.200 (1_Supplement), p.102-102.16

2018

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Antigen-specific B cell depletion with desmoglein 3 chimeric autoantibody receptor T cells (DSG3-CAART) for targeted therapy of mucosal pemphigus vulgaris

The Journal of immunology (1950), 2020-05, Vol.204 (1_Supplement), p.238-238.2

2020

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Autoantibody cross-reactivity with a microbial protein from a prevalent human gut commensal in antiphospholipid syndrome

The Journal of immunology (1950), 2017-05, Vol.198 (1_Supplement), p.58-58.4

2017

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Autoantigen‐specific T and B Cell Cross‐reactivity to a Gut Commensal in Antiphospholipid Syndrome

The FASEB journal, 2017-04, Vol.31 (S1)

2017

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Asymmetric and symmetric triazenido cyclopalladated complexes: Synthesis, structural analysis and DFT calculations

Journal of molecular structure, 2015-03, Vol.1083, p.311-318

2015

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Spontaneous translocation of a human enterococcal gut pathobiont drives systemic autoimmunity

The Journal of immunology (1950), 2018-05, Vol.200 (1_Supplement), p.162-162.10

2018

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Prevention of systemic autoimmunity by dietary modulation of the gut microbiota

The Journal of immunology (1950), 2018-05, Vol.200 (1_Supplement), p.54-54.1

2018

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The H+-pyrophosphatase of Rhodospirillum rubrum Is Predominantly Located in Polyphosphate-rich Acidocalcisomes

The Journal of biological chemistry, 2004-12, Vol.279 (49), p.51193-51202

2004

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Gut commensal dependence of autoreactivity and Th17 cells in systemic autoimmunity (MUC9P.740)

The Journal of immunology (1950), 2015-05, Vol.194 (1_Supplement), p.205-205.4

2015

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Spontaneous Translocation of a Gut Pathobiont Drives Autoimmunity that is Preventable by Intramuscular Vaccination

The Journal of immunology (1950), 2017-05, Vol.198 (1_Supplement), p.199-199.20

2017

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The preclinical journey: transitioning a novel cell therapy into early phase clinical trials

Cell and Gene Therapy Insights, 2024-01, Vol.10 (2), p.171-177

Manfredo-Vieira, Silvio

2024

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Translocation of a gut pathobiont drives autoimmunity in mice and humans

564 Preclinical rationale for a first-in-human trial to evaluate the safety and preliminary efficacy of desmoglein 3 chimeric autoantibody receptor T cells (DSG3-CAART) for mucosal pemphigus vulgaris

A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity

Mechanisms and consequences of gut commensal translocation in chronic diseases

Bruton’s Tyrosine Kinase Inhibition in Pemphigus: An Embattled Frontier

Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris

Assessment of the biological potential of diaryltriazene-derived triazene compounds

Nature of the multicomponent crystal of salicylic acid and 1,2-phenylenediamine

Chimeric Autoantibody Receptor (CAAR) T Cells as a Precision Therapy for Antigen-Specific B Cell Depletion in PLA2R Membranous Nephropathy: FR-OR32

Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity

Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells

Regulation of type 17 helper T-cell function by nitric oxide during inflammation

T cell and bacterial microbiota interaction at intestinal and skin epithelial interfaces

Identification of Organelles in Bacteria Similar to Acidocalcisomes of Unicellular Eukaryotes

Gut pathobiont translocation induces lymphocyte migration to internal organs in autoimmunity

Antigen-specific B cell depletion with desmoglein 3 chimeric autoantibody receptor T cells (DSG3-CAART) for targeted therapy of mucosal pemphigus vulgaris

Autoantibody cross-reactivity with a microbial protein from a prevalent human gut commensal in antiphospholipid syndrome

Autoantigen‐specific T and B Cell Cross‐reactivity to a Gut Commensal in Antiphospholipid Syndrome

Asymmetric and symmetric triazenido cyclopalladated complexes: Synthesis, structural analysis and DFT calculations

Spontaneous translocation of a human enterococcal gut pathobiont drives systemic autoimmunity

Prevention of systemic autoimmunity by dietary modulation of the gut microbiota

The H+-pyrophosphatase of Rhodospirillum rubrum Is Predominantly Located in Polyphosphate-rich Acidocalcisomes

Gut commensal dependence of autoreactivity and Th17 cells in systemic autoimmunity (MUC9P.740)

Spontaneous Translocation of a Gut Pathobiont Drives Autoimmunity that is Preventable by Intramuscular Vaccination

The preclinical journey: transitioning a novel cell therapy into early phase clinical trials

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