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Model-Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development

Clinical pharmacology and therapeutics, 2013-06, Vol.93 (6), p.502-514

2013

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A dose–response Meta‐Analysis for Quantifying Relative Efficacy of Biologics in Rheumatoid Arthritis

Clinical pharmacology and therapeutics, 2011-12, Vol.90 (6), p.828-835

2011

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Model‐Based Meta‐Analysis for Comparative Efficacy and Safety: Application in Drug Development and Beyond

Clinical pharmacology and therapeutics, 2011-12, Vol.90 (6), p.766-769

2011

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Direct Oral Anticoagulants Vs. Enoxaparin for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose–Response Meta‐analysis

Clinical and translational science, 2017-07, Vol.10 (4), p.260-270

2017

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An adaptive‐design dose‐ranging study of PD 0348292, an oral factor Xa inhibitor, for thromboprophylaxis after total knee replacement surgery

Journal of thrombosis and haemostasis, 2013-08, Vol.11 (8), p.1503-1510

2013

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Therapeutic Index of Anticoagulants for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose–Response Meta‐Analysis

Clinical pharmacology and therapeutics, 2011-12, Vol.90 (6), p.820-827

2011

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Model‐Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development

Clinical pharmacology and therapeutics, 2013-06, Vol.93 (6), p.502-514

2013

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Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain — Results of a Model-Based Meta-Analysis that Accounts for Encapsulation

Cephalalgia, 2005-09, Vol.25 (9), p.715-725

2005

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Characterization and validation of a pharmacokinetic model for controlled‐release oxycodone

British journal of clinical pharmacology, 1996-12, Vol.42 (6), p.747-756

1996

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The pharmacokinetics of propofol in children using three different data analysis approaches

Anesthesiology (Philadelphia), 1994, Vol.80 (1), p.104-122

1994

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Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: midazolam and alpha-OH-midazolam

The Journal of pharmacology and experimental therapeutics, 1999-05, Vol.289 (2), p.1067

1999

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Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs

Clinical pharmacokinetics, 1992-09, Vol.23 (3), p.191-215

1992

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Pharmacodynamic model for acute tolerance development to the electroencephalographic effects of alfentanil in the rat

The Journal of pharmacology and experimental therapeutics, 1995-12, Vol.275 (3), p.1185

1995

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Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain

British journal of pharmacology, 1995-11, Vol.116 (5), p.2538-2544

1995

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Pharmacokinetic‐pharmacodynamic modelling of the EEG effects of midazolam in individual rats: influence of rate and route of administration

British journal of pharmacology, 1991-03, Vol.102 (3), p.663-668

1991

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Relevance of arteriovenous concentration differences in pharmacokinetic-pharmacodynamic modeling of midazolam

The Journal of pharmacology and experimental therapeutics, 1998-01, Vol.284 (1), p.202

1998

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Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite α-hydroxymidazolam in healthy volunteers

Clinical pharmacology and therapeutics, 1992-06, Vol.51 (6), p.715-728

1992

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Pharmacokinetic-pharmacodynamic characterization of the cardiovascular, hypnotic, EEG and ventilatory responses to dexmedetomidine in the rat

The Journal of pharmacology and experimental therapeutics, 1997-12, Vol.283 (3), p.1051

1997

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Pharmacokinetic-pharmacodynamic modeling of the electroencephalographic effects of benzodiazepines. Correlation with receptor binding and anticonvulsant activity

The Journal of pharmacology and experimental therapeutics, 1991-04, Vol.257 (1), p.472

1991

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Pharmacokinetic-pharmacodynamic modeling of the anticonvulsant and electroencephalogram effects of phenytoin in rats

The Journal of pharmacology and experimental therapeutics, 1998-02, Vol.284 (2), p.460

1998

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Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration‐EEG effect relationship

British journal of pharmacology, 1992-01, Vol.105 (1), p.164-170

1992

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Pharmacokinetic/pharmacodynamic relationship of benzodiazepines in the direct cortical stimulation model of anticonvulsant effect

The Journal of pharmacology and experimental therapeutics, 1996-11, Vol.279 (2), p.803

1996

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Thiopental uncouples hippocampal and cortical synchronized electroencephalographic activity

Anesthesiology (Philadelphia), 1996-06, Vol.84 (6), p.1411-1424

1996

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Population pharmacodynamic modeling and covariate detection for central neural blockade

Anesthesiology (Philadelphia), 1996-09, Vol.85 (3), p.502-512

1996

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Population pharmacodynamic model for ketorolac analgesia

Clinical pharmacology and therapeutics, 1996-12, Vol.60 (6), p.619-635

1996

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Model-Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development

A dose–response Meta‐Analysis for Quantifying Relative Efficacy of Biologics in Rheumatoid Arthritis

Model‐Based Meta‐Analysis for Comparative Efficacy and Safety: Application in Drug Development and Beyond

Direct Oral Anticoagulants Vs. Enoxaparin for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose–Response Meta‐analysis

An adaptive‐design dose‐ranging study of PD 0348292, an oral factor Xa inhibitor, for thromboprophylaxis after total knee replacement surgery

Therapeutic Index of Anticoagulants for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose–Response Meta‐Analysis

Model‐Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development

Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain — Results of a Model-Based Meta-Analysis that Accounts for Encapsulation

Characterization and validation of a pharmacokinetic model for controlled‐release oxycodone

The pharmacokinetics of propofol in children using three different data analysis approaches

Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: midazolam and alpha-OH-midazolam

Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs

Pharmacodynamic model for acute tolerance development to the electroencephalographic effects of alfentanil in the rat

Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain

Pharmacokinetic‐pharmacodynamic modelling of the EEG effects of midazolam in individual rats: influence of rate and route of administration

Relevance of arteriovenous concentration differences in pharmacokinetic-pharmacodynamic modeling of midazolam

Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite α-hydroxymidazolam in healthy volunteers

Pharmacokinetic-pharmacodynamic characterization of the cardiovascular, hypnotic, EEG and ventilatory responses to dexmedetomidine in the rat

Pharmacokinetic-pharmacodynamic modeling of the electroencephalographic effects of benzodiazepines. Correlation with receptor binding and anticonvulsant activity

Pharmacokinetic-pharmacodynamic modeling of the anticonvulsant and electroencephalogram effects of phenytoin in rats

Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration‐EEG effect relationship

Pharmacokinetic/pharmacodynamic relationship of benzodiazepines in the direct cortical stimulation model of anticonvulsant effect

Thiopental uncouples hippocampal and cortical synchronized electroencephalographic activity

Population pharmacodynamic modeling and covariate detection for central neural blockade

Population pharmacodynamic model for ketorolac analgesia

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