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The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?

Trends in endocrinology and metabolism, 2013-08, Vol.24 (8), p.398-407

2013

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β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1

The Journal of biological chemistry, 2015-08, Vol.290 (34), p.21131-21140

2015

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Common coupling map advances GPCR-G protein selectivity

eLife, 2022-03, Vol.11

2022

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Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity

Nature communications, 2023-07, Vol.14 (1), p.3953-3953, Article 3953

2023

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Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1

Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (7), p.2376-2381

2012

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The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets

Molecular metabolism (Germany), 2016-10, Vol.5 (10), p.988-996

2016

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Exploring the Technology Landscape of 7TMR Drug Signaling Profiling

Current topics in medicinal chemistry, 2015-01, Vol.15 (24), p.2528

2015

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EGFR signaling and pharmacology in oncology revealed with innovative BRET-based biosensors

Communications biology, 2024-03, Vol.7 (1), p.250-250, Article 250

2024

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Membrane fatty acid receptors in the β-cell: novel therapeutic targets for type 2 diabetes

M.S. Médecine sciences, 2013-08, Vol.29 (8-9), p.715

2013

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Leukotriene B4 BLT Receptor Signaling Regulates the Level and Stability of Cyclooxygenase-2 (COX-2) mRNA through Restricted Activation of Ras/Raf/ERK/p42 AUF1 Pathway

The Journal of biological chemistry, 2010-07, Vol.285 (31), p.23568-23580

2010

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Transcriptional regulation of matrix metalloprotease gene expression in health and disease

Frontiers in bioscience, 2006-01, Vol.11, p.423

2006

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GPR40 agonists for the treatment of type 2 diabetes: life after 'TAKing' a hit

Diabetes, obesity & metabolism, 2015-07, Vol.17 (7), p.622-629

2015

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TAK-875 is a Partial Agonist of the Free Fatty Acid Receptor GPR40

Canadian journal of diabetes, 2013-10, Vol.37, p.S59-S59

2013

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A systematic analysis of prostaglandin E2 type 3 receptor isoform signaling reveals isoform- and species-dependent L798106 Gαz-biased agonist responses

European journal of pharmacology, 2022-07, Vol.927, p.175043-175043, Article 175043

2022

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Abstract LB-004: Signaling signature profiling of cancer-associated RTK mutants

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.LB-004-LB-004

2019

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Abstract LB187: EGFR signaling and pharmacology in oncology revealed with an innovative RTK biosensor technology

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.LB187-LB187

2021

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Free Fatty Acid Receptor 1: A New Drug Target for Type 2 Diabetes?

Canadian journal of diabetes, 2012-10, Vol.36 (5), p.275-280

2012

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Abstract 6304: Decrypting EGFR signaling with BRET biosensors: A novel approach to study RTK mutations and the effects of inhibitors

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.6304-6304

2020

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Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome

Chemical science (Cambridge), 2021-08, Vol.12 (33), p.199-113

2021

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GPR40-Mediated G α 12 Activation by Allosteric Full Agonists Highly Efficacious at Potentiating Glucose-Stimulated Insulin Secretion in Human Islets

Molecular pharmacology, 2018-06, Vol.93 (6), p.581-591

2018

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Profiling the Signaling Repertoire of One Hundred Therapeutically‐Relevant Human GPCRs

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Use of Novel ebBRET Biosensors for Comprehensive Signaling Profiling of One Hundred Therapeutically Relevant Human GPCRs

The FASEB journal, 2021-05, Vol.35 (S1), p.n/a, Article fasebj.2021.35.S1.01694

2021

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Large‐scale profiling of physiologically relevant naturally occurring rare GPCR variants using the bioSensAll® technology

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Prostaglandin E2 Stimulates p53 Transactivational Activity through Specific Serine 15 Phosphorylation in Human Synovial Fibroblasts

The Journal of biological chemistry, 2006-07, Vol.281 (29), p.19849-19860

2006

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The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?

β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1

Common coupling map advances GPCR-G protein selectivity

Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs

Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity

Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1

The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets

Exploring the Technology Landscape of 7TMR Drug Signaling Profiling

EGFR signaling and pharmacology in oncology revealed with innovative BRET-based biosensors

Membrane fatty acid receptors in the β-cell: novel therapeutic targets for type 2 diabetes

Leukotriene B4 BLT Receptor Signaling Regulates the Level and Stability of Cyclooxygenase-2 (COX-2) mRNA through Restricted Activation of Ras/Raf/ERK/p42 AUF1 Pathway

Transcriptional regulation of matrix metalloprotease gene expression in health and disease

GPR40 agonists for the treatment of type 2 diabetes: life after 'TAKing' a hit

TAK-875 is a Partial Agonist of the Free Fatty Acid Receptor GPR40

A systematic analysis of prostaglandin E2 type 3 receptor isoform signaling reveals isoform- and species-dependent L798106 Gαz-biased agonist responses

Abstract LB-004: Signaling signature profiling of cancer-associated RTK mutants

Abstract LB187: EGFR signaling and pharmacology in oncology revealed with an innovative RTK biosensor technology

Free Fatty Acid Receptor 1: A New Drug Target for Type 2 Diabetes?

Abstract 6304: Decrypting EGFR signaling with BRET biosensors: A novel approach to study RTK mutations and the effects of inhibitors

Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome

GPR40-Mediated G α 12 Activation by Allosteric Full Agonists Highly Efficacious at Potentiating Glucose-Stimulated Insulin Secretion in Human Islets

Profiling the Signaling Repertoire of One Hundred Therapeutically‐Relevant Human GPCRs

Use of Novel ebBRET Biosensors for Comprehensive Signaling Profiling of One Hundred Therapeutically Relevant Human GPCRs

Large‐scale profiling of physiologically relevant naturally occurring rare GPCR variants using the bioSensAll® technology

Prostaglandin E2 Stimulates p53 Transactivational Activity through Specific Serine 15 Phosphorylation in Human Synovial Fibroblasts

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