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The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions

Microvascular research, 2009-03, Vol.77 (2), p.78-86

2009

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A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.535-542

2018

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Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (1), p.360-365

2013

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1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4

Bioorganic & medicinal chemistry, 2011-11, Vol.19 (21), p.6356-6374

2011

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Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.1222-1232

2003

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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-a Inhibitor

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1522-1524

2009

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Asymmetric Synthesis of Stegobinone via Boronic Ester Chemistry

Journal of the American Chemical Society, 1996-05, Vol.118 (19), p.4560-4566

1996

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A Highly Enantioselective and Diastereoselective Synthesis of Cyclobutanes via Boronic Esters

Organic letters, 1999-08, Vol.1 (3), p.379-382

1999

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Antiproliferative effects of CC-8062 and CC-8075 in pancreatic cancer cells

Pancreas, 2009-01, Vol.38 (1), p.78-84

2009

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Nonpeptide Cyclic Cyanoguanidines as HIV-1 Protease Inhibitors: Synthesis, Structure−Activity Relationships, and X-ray Crystal Structure Studies

Journal of medicinal chemistry, 1998-04, Vol.41 (9), p.1446-1455

1998

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α-Fluoro-substituted thalidomide analogues

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (20), p.3415-3417

2003

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Enantioselective Capture and Retroracemization of (1-Bromoalkyl)boronic Esters by an N-Propanoyloxazolidinone Enolate and Iodide Ion

Journal of organic chemistry, 1994-09, Vol.59 (19), p.5734-5741

1994

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A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase-dependent apoptosis is associated with altered expression of bcl-2 family proteins

Cancer research (Chicago, Ill.), 2003-02, Vol.63 (3), p.593-599

2003

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Potent inhibition of cytokine production from intestinal lamina propria T cells by phosphodiesterase-4 inhibitory thalidomide analogues

Journal of clinical immunology, 2001-09, Vol.21 (5), p.357-364

2001

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Effect of 3-fluorothalidomide and 3-methylthalidomide enantiomers on tumor necrosis factor production and antitumor responses to the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)

Oncology research, 2003, Vol.14 (2), p.75-82

2003

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Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

Nature (London), 2015-07, Vol.523 (7559), p.183-188

2015

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Selective cytokine inhibitory drugs with enhanced antiangiogenic activity control tumor growth through vascular inhibition

Cancer research (Chicago, Ill.), 2003-12, Vol.63 (23), p.8073-8078

2003

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Hydrolysis of Substituted 1,3,2-Dioxaborolanes and an Asymmetric Synthesis of a Differentially Protected syn,syn-3-Methyl-2,4-hexanediol

Journal of organic chemistry, 1996-08, Vol.61 (17), p.6047-6051

1996

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Synthesis of 7-membered cyclic oxamides: Novel HIV-1 protease inhibitors

Tetrahedron letters, 1996-02, Vol.37 (8), p.1153-1156

1996

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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1522-1524

2009

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Direct Synthesis of [α-[(tert-Butoxycarbonyl)amino]alkyl]- boronates from (α-Haloalkyl)boronates

Journal of organic chemistry, 1996-11, Vol.61 (22), p.7951-7954

1996

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High-precision asymmetric synthesis of stegobiol and stegobinone via boronic esters

Journal of organic chemistry, 1993-11, Vol.58 (24), p.6545-6547

1993

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Protein Degradation via CRL4CRBN Ubiquitin Ligase: Discovery and Structure–Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.492-503

2018

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Protein Degradation via CRL4 CRBN Ubiquitin Ligase: Discovery and Structure-Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.492-503

2018

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CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions

A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos

Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4

Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-a Inhibitor

Asymmetric Synthesis of Stegobinone via Boronic Ester Chemistry

A Highly Enantioselective and Diastereoselective Synthesis of Cyclobutanes via Boronic Esters

Antiproliferative effects of CC-8062 and CC-8075 in pancreatic cancer cells

Nonpeptide Cyclic Cyanoguanidines as HIV-1 Protease Inhibitors: Synthesis, Structure−Activity Relationships, and X-ray Crystal Structure Studies

α-Fluoro-substituted thalidomide analogues

Enantioselective Capture and Retroracemization of (1-Bromoalkyl)boronic Esters by an N-Propanoyloxazolidinone Enolate and Iodide Ion

A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase-dependent apoptosis is associated with altered expression of bcl-2 family proteins

Potent inhibition of cytokine production from intestinal lamina propria T cells by phosphodiesterase-4 inhibitory thalidomide analogues

Effect of 3-fluorothalidomide and 3-methylthalidomide enantiomers on tumor necrosis factor production and antitumor responses to the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

Selective cytokine inhibitory drugs with enhanced antiangiogenic activity control tumor growth through vascular inhibition

Hydrolysis of Substituted 1,3,2-Dioxaborolanes and an Asymmetric Synthesis of a Differentially Protected syn,syn-3-Methyl-2,4-hexanediol

Synthesis of 7-membered cyclic oxamides: Novel HIV-1 protease inhibitors

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

Direct Synthesis of [α-[(tert-Butoxycarbonyl)amino]alkyl]- boronates from (α-Haloalkyl)boronates

High-precision asymmetric synthesis of stegobiol and stegobinone via boronic esters

Protein Degradation via CRL4CRBN Ubiquitin Ligase: Discovery and Structure–Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1

Protein Degradation via CRL4 CRBN Ubiquitin Ligase: Discovery and Structure-Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1

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