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Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase

Journal of medicinal chemistry, 2014-08, Vol.57 (15), p.6594-6609

2014

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The Transcription Factor Neural Retina Leucine Zipper (NRL) Controls Photoreceptor-specific Expression of Myocyte Enhancer Factor Mef2c from an Alternative Promoter

The Journal of biological chemistry, 2011-10, Vol.286 (40), p.34893-34902

2011

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Plasminogen activators promote excitotoxicity-induced retinal damage

The FASEB journal, 2005-08, Vol.19 (10), p.1280-1289

2005

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Intravitreous Injection of a Membrane Depolarization Agent Causes Retinal Degeneration Via Matrix Metalloproteinase-9

Investigative ophthalmology & visual science, 2005-06, Vol.46 (6), p.2125-2132

2005

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PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML

Blood, 2014-05, Vol.123 (18), p.2838-2842

2014

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A decrease in phosphorylation of cAMP-response element-binding protein (CREBP) promotes retinal degeneration

Experimental eye research, 2011-06, Vol.92 (6), p.528-536

2011

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Temporal ChIP-on-Chip of RNA-Polymerase-II to detect novel gene activation events during photoreceptor maturation

Molecular vision, 2010-02, Vol.16, p.252-271

2010

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FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo

BMC molecular biology, 2008-10, Vol.9 (1), p.87-87

2008

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FIZ1 is expressed during photoreceptor maturation, and synergizes with NRL and CRX at rod-specific promoters in vitro

Experimental eye research, 2007-02, Vol.84 (2), p.349-360

2007

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Abstract 6156: MALT1 protease inhibition overcomes BTK inhibitor resistance and shows synergistic activity with venetoclax in models of B cell lymphoma and leukemia

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.6156-6156

2023

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p85α Regulates Osteoblast Differentiation by Cross-talking with the MAPK Pathway

The Journal of biological chemistry, 2011-04, Vol.286 (15), p.13512-13521

2011

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p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway

The Journal of biological chemistry, 2011-04, Vol.286 (15), p.13512-13521

2011

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Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models

Haematologica (Roma), 2021-04, Vol.106 (4), p.1034-1046

2021

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Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

Cell stem cell, 2018-12, Vol.23 (6), p.833-849.e5

2018

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Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL

Cancer cell, 2011-09, Vol.20 (3), p.357-369

2011

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Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

Cell reports (Cambridge), 2014-11, Vol.9 (4), p.1333-1348

2014

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Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Blood, 2012-09, Vol.120 (13), p.2669-2678

2012

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Extended Follow-up and Resistance Mutations in CLL Patients Treated with Acalabrutinib

Blood, 2023-11, Vol.142 (Supplement 1), p.1891-1891

2023

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Targeting MCL‐1 and BCL‐2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non‐Hodgkin lymphoma: Results from preclinical models and a Phase Ib study

American journal of hematology, 2023-03, Vol.98 (3), p.449-463

2023

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Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis

PloS one, 2012-08, Vol.7 (8), p.e43090-e43090

2012

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Combined Heterozygous Loss of Tet2 and Dnmt3a Along with Expression of Flt3ITD/WT results in Acute Myeloid Leukemia Which Responds to a Combination of FLT3 Inhibitor, APE1 Inhibitor and Decitabine

Blood, 2019-11, Vol.134 (Supplement_1), p.3754-3754

2019

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Role of Rho kinases in abnormal and normal hematopoiesis

Current opinion in hematology, 2014-07, Vol.21 (4), p.271-275

2014

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The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor

Blood, 2011-09, Vol.118 (13), p.3459-3469

2011

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Pak and Rac GTPases promote oncogenic KIT-induced neoplasms

The Journal of clinical investigation, 2013-10, Vol.123 (10), p.4449-4463

2013

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ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53

Blood, 2012-10, Vol.120 (14), p.2868-2878

2012

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Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase

The Transcription Factor Neural Retina Leucine Zipper (NRL) Controls Photoreceptor-specific Expression of Myocyte Enhancer Factor Mef2c from an Alternative Promoter

Plasminogen activators promote excitotoxicity-induced retinal damage

Intravitreous Injection of a Membrane Depolarization Agent Causes Retinal Degeneration Via Matrix Metalloproteinase-9

PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML

A decrease in phosphorylation of cAMP-response element-binding protein (CREBP) promotes retinal degeneration

Temporal ChIP-on-Chip of RNA-Polymerase-II to detect novel gene activation events during photoreceptor maturation

FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo

FIZ1 is expressed during photoreceptor maturation, and synergizes with NRL and CRX at rod-specific promoters in vitro

Abstract 6156: MALT1 protease inhibition overcomes BTK inhibitor resistance and shows synergistic activity with venetoclax in models of B cell lymphoma and leukemia

p85α Regulates Osteoblast Differentiation by Cross-talking with the MAPK Pathway

p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway

Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Extended Follow-up and Resistance Mutations in CLL Patients Treated with Acalabrutinib

Targeting MCL‐1 and BCL‐2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non‐Hodgkin lymphoma: Results from preclinical models and a Phase Ib study

Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis

Combined Heterozygous Loss of Tet2 and Dnmt3a Along with Expression of Flt3ITD/WT results in Acute Myeloid Leukemia Which Responds to a Combination of FLT3 Inhibitor, APE1 Inhibitor and Decitabine

Role of Rho kinases in abnormal and normal hematopoiesis

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor

Pak and Rac GTPases promote oncogenic KIT-induced neoplasms

ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53

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