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Proteases as therapeutics

Biochemical journal, 2011-04, Vol.435 (1), p.1-16

2011

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Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer

Cancer and metastasis reviews, 2003-06, Vol.22 (2-3), p.237-258

2003

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CVS-3983, a selective matriptase inhibitor, suppresses the growth of androgen independent prostate tumor xenografts

The Prostate, 2004-11, Vol.61 (3), p.228-235

2004

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Catalytic Domain Structures of MT-SP1/Matriptase, a Matrix-degrading Transmembrane Serine Proteinase

The Journal of biological chemistry, 2002-01, Vol.277 (3), p.2160-2168

2002

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Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family

The FEBS journal, 2007-04, Vol.274 (8), p.2148-2160

2007

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The Kringle V-protease domain is a fibrinogen binding region within Apo(a)

Thrombosis and haemostasis, 2001-11, Vol.86 (5), p.1229-1237

2001

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Serpin-resistant mutants of human tissue-type plasminogen activator

Nature (London), 1989-06, Vol.339 (6227), p.721-724

1989

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Identification of Efficiently Cleaved Substrates for HIV-1 Protease Using a Phage Display Library and Use in Inhibitor Development

Virology (New York, N.Y.), 2000-09, Vol.274 (2), p.391-401

2000

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Optimal Subsite Occupancy and Design of a Selective Inhibitor of Urokinase

The Journal of biological chemistry, 1997-08, Vol.272 (33), p.20456-20462

1997

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Converting Tissue Plasminogen Activator to a Zymogen: A Regulatory Triad of Asp-His-Ser

Science (American Association for the Advancement of Science), 1993-10, Vol.262 (5132), p.419-421

1993

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Binding of Nonphysiological Protein and Peptide Substrates to Proteases: Differences between Urokinase-Type Plasminogen Activator and Trypsin and Contributions to the Evolution of Regulated Proteolysis

Biochemistry (Easton), 2003-05, Vol.42 (18), p.5395-5402

2003

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Revisiting Catalysis by Chymotrypsin Family Serine Proteases Using Peptide Substrates and Inhibitors with Unnatural Main Chains

The Journal of biological chemistry, 1999-08, Vol.274 (34), p.24074-24079

1999

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Converting Tissue-type Plasminogen Activator into a Zymogen

The Journal of biological chemistry, 1996-11, Vol.271 (46), p.28749-28752

1996

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Comparison of the effects of Apo(a) kringle IV-10 and plasminogen kringles on the interactions of lipoprotein(a) with regulatory molecules

Thrombosis and haemostasis, 1999-03, Vol.81 (3), p.428-435

1999

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Rapid and efficient site-directed mutagenesis by single-tube 'megaprimer' PCR method

Nucleic acids research, 1997-08, Vol.25 (16), p.3371-3372

1997

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A tissue plasminogen activator/P-selectin fusion protein is an effective thrombolytic agent

Circulation (New York, N.Y.), 1997-02, Vol.95 (3), p.715-722

1997

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Variants of Tissue-type Plasminogen Activator Which Display Substantially Enhanced Stimulation by Fibrin

The Journal of biological chemistry, 1995-08, Vol.270 (31), p.18319-18322

1995

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Distinct Mechanisms Contribute to Stringent Substrate Specificity of Tissue-type Plasminogen Activator (∗)

The Journal of biological chemistry, 1996-02, Vol.271 (8), p.4461-4467

1996

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Variants of Tissue-type Plasminogen Activator That Display Extraordinary Resistance to Inhibition by the Serpin Plasminogen Activator Inhibitor Type 1

The Journal of biological chemistry, 1997-06, Vol.272 (23), p.14580-14585

1997

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Converting Tissue Type Plasminogen Activator into a Zymogen

The Journal of biological chemistry, 1997-01, Vol.272 (1), p.28-31

1997

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Variants of Tissue-type Plasminogen Activator with Substantially Enhanced Response and Selectivity toward Fibrin Co-factors (∗)

The Journal of biological chemistry, 1995-10, Vol.270 (40), p.23444-23449

1995

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Distinct Contributions of Residue 192 to the Specificity of Coagulation and Fibrinolytic Serine Proteases

The Journal of biological chemistry, 1999-03, Vol.274 (11), p.7153-7156

1999

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Crystals of Urokinase Type Plasminogen Activator Complexes Reveal the Binding Mode of Peptidomimetic Inhibitors

Journal of molecular biology, 2003-04, Vol.328 (1), p.109-118

2003

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Identification of a Hydrophobic Exosite on Tissue Type Plasminogen Activator That Modulates Specificity for Plasminogen

The Journal of biological chemistry, 1997-01, Vol.272 (3), p.1811-1816

1997

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Directing Sequence-specific Proteolysis to New Targets

The Journal of biological chemistry, 1998-02, Vol.273 (8), p.4323-4328

1998

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Proteases as therapeutics

Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer

CVS-3983, a selective matriptase inhibitor, suppresses the growth of androgen independent prostate tumor xenografts

Catalytic Domain Structures of MT-SP1/Matriptase, a Matrix-degrading Transmembrane Serine Proteinase

Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family

The Kringle V-protease domain is a fibrinogen binding region within Apo(a)

Serpin-resistant mutants of human tissue-type plasminogen activator

Identification of Efficiently Cleaved Substrates for HIV-1 Protease Using a Phage Display Library and Use in Inhibitor Development

Optimal Subsite Occupancy and Design of a Selective Inhibitor of Urokinase

Converting Tissue Plasminogen Activator to a Zymogen: A Regulatory Triad of Asp-His-Ser

Binding of Nonphysiological Protein and Peptide Substrates to Proteases: Differences between Urokinase-Type Plasminogen Activator and Trypsin and Contributions to the Evolution of Regulated Proteolysis

Revisiting Catalysis by Chymotrypsin Family Serine Proteases Using Peptide Substrates and Inhibitors with Unnatural Main Chains

Converting Tissue-type Plasminogen Activator into a Zymogen

Comparison of the effects of Apo(a) kringle IV-10 and plasminogen kringles on the interactions of lipoprotein(a) with regulatory molecules

Rapid and efficient site-directed mutagenesis by single-tube 'megaprimer' PCR method

A tissue plasminogen activator/P-selectin fusion protein is an effective thrombolytic agent

Variants of Tissue-type Plasminogen Activator Which Display Substantially Enhanced Stimulation by Fibrin

Distinct Mechanisms Contribute to Stringent Substrate Specificity of Tissue-type Plasminogen Activator (∗)

Variants of Tissue-type Plasminogen Activator That Display Extraordinary Resistance to Inhibition by the Serpin Plasminogen Activator Inhibitor Type 1

Converting Tissue Type Plasminogen Activator into a Zymogen

Variants of Tissue-type Plasminogen Activator with Substantially Enhanced Response and Selectivity toward Fibrin Co-factors (∗)

Distinct Contributions of Residue 192 to the Specificity of Coagulation and Fibrinolytic Serine Proteases

Crystals of Urokinase Type Plasminogen Activator Complexes Reveal the Binding Mode of Peptidomimetic Inhibitors

Identification of a Hydrophobic Exosite on Tissue Type Plasminogen Activator That Modulates Specificity for Plasminogen

Directing Sequence-specific Proteolysis to New Targets

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