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Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

Proceedings of the National Academy of Sciences - PNAS, 1992-08, Vol.89 (16), p.7422-7426

1992

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Amino Acid Residues that Affect Interaction of Tissue-Type Plasminogen Activator with Plasminogen Activator Inhibitor 1

Proceedings of the National Academy of Sciences - PNAS, 1990-05, Vol.87 (9), p.3530-3533

1990

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Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1-dependent and -independent mechanisms

Blood, 1994-01, Vol.83 (2), p.351-356

1994

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Origins of the Specificity of Tissue-Type Plasminogen Activator

Proceedings of the National Academy of Sciences - PNAS, 1995-08, Vol.92 (17), p.7627-7631

1995

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The Kringle V-protease domain is a fibrinogen binding region within Apo(a)

Thrombosis and haemostasis, 2001-11, Vol.86 (5), p.1229

2001

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Serpin-resistant mutants of human tissue-type plasminogen activator

Nature (London), 1989-06, Vol.339 (6227), p.721-724

1989

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Rapid and efficient site-directed mutagenesis by single-tube 'megaprimer' PCR method

Nucleic acids research, 1997-08, Vol.25 (16), p.3371

1997

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Converting Tissue Plasminogen Activator to a Zymogen: A Regulatory Triad of Asp-His-Ser

Science (American Association for the Advancement of Science), 1993-10, Vol.262 (5132), p.419-421

1993

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Restoration of serine protease-inhibitor interaction by protein engineering

The Journal of biological chemistry, 1990-12, Vol.265 (35), p.21423-21426

1990

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Variants of human tissue‐type plasminogen activator that lack specific structural domains of the heavy chain

The EMBO journal, 1988-09, Vol.7 (9), p.2731-2740

1988

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Identification of Efficiently Cleaved Substrates for HIV-1 Protease Using a Phage Display Library and Use in Inhibitor Development

Virology (New York, N.Y.), 2000-09, Vol.274 (2), p.391-401

2000

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Comparison of the effects of Apo(a) kringle IV-10 and plasminogen kringles on the interactions of lipoprotein(a) with regulatory molecules

Thrombosis and haemostasis, 1999-03, Vol.81 (3), p.428

1999

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Studies of serpins unfold at a feverish pace

The Journal of clinical investigation, 1994-12, Vol.94 (6), p.2174-2175

Madison, E L

1994

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A tissue plasminogen activator/P-selectin fusion protein is an effective thrombolytic agent

Circulation (New York, N.Y.), 1997-02, Vol.95 (3), p.715-722

1997

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Optimal Subsite Occupancy and Design of a Selective Inhibitor of Urokinase

The Journal of biological chemistry, 1997-08, Vol.272 (33), p.20456-20462

1997

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A vector, pSHT, for the expression and secretion of protein domains in mammalian cells

Gene, 1992-11, Vol.121 (1), p.179-180

1992

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Inhibitor-resistant tissue-type plasminogen activator: an improved thrombolytic agent in vitro

Thrombosis and haemostasis, 1994-01, Vol.71 (1), p.124

1994

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Revisiting Catalysis by Chymotrypsin Family Serine Proteases Using Peptide Substrates and Inhibitors with Unnatural Main Chains

The Journal of biological chemistry, 1999-08, Vol.274 (34), p.24074-24079

1999

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Converting Tissue-type Plasminogen Activator into a Zymogen

The Journal of biological chemistry, 1996-11, Vol.271 (46), p.28749-28752

1996

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Substrate specificity of tissue type plasminogen activator. Characterization of the fibrin independent specificity of t-PA for plasminogen

The Journal of biological chemistry, 1995-03, Vol.270 (13), p.7558-7562

1995

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Distinguishing the specificities of closely related proteases. Role of P3 in substrate and inhibitor discrimination between tissue-type plasminogen activator and urokinase

The Journal of biological chemistry, 1997-06, Vol.272 (26), p.16603

1997

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Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer

Cancer and metastasis reviews, 2003-06, Vol.22 (2-3), p.237-258

2003

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Variants of Tissue-type Plasminogen Activator Which Display Substantially Enhanced Stimulation by Fibrin

The Journal of biological chemistry, 1995-08, Vol.270 (31), p.18319-18322

1995

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Distinct Mechanisms Contribute to Stringent Substrate Specificity of Tissue-type Plasminogen Activator (∗)

The Journal of biological chemistry, 1996-02, Vol.271 (8), p.4461-4467

1996

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Variants of Tissue-type Plasminogen Activator That Display Extraordinary Resistance to Inhibition by the Serpin Plasminogen Activator Inhibitor Type 1

The Journal of biological chemistry, 1997-06, Vol.272 (23), p.14580-14585

1997

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Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

Amino Acid Residues that Affect Interaction of Tissue-Type Plasminogen Activator with Plasminogen Activator Inhibitor 1

Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1-dependent and -independent mechanisms

Origins of the Specificity of Tissue-Type Plasminogen Activator

The Kringle V-protease domain is a fibrinogen binding region within Apo(a)

Serpin-resistant mutants of human tissue-type plasminogen activator

Rapid and efficient site-directed mutagenesis by single-tube 'megaprimer' PCR method

Converting Tissue Plasminogen Activator to a Zymogen: A Regulatory Triad of Asp-His-Ser

Restoration of serine protease-inhibitor interaction by protein engineering

Variants of human tissue‐type plasminogen activator that lack specific structural domains of the heavy chain

Identification of Efficiently Cleaved Substrates for HIV-1 Protease Using a Phage Display Library and Use in Inhibitor Development

Comparison of the effects of Apo(a) kringle IV-10 and plasminogen kringles on the interactions of lipoprotein(a) with regulatory molecules

Studies of serpins unfold at a feverish pace

A tissue plasminogen activator/P-selectin fusion protein is an effective thrombolytic agent

Optimal Subsite Occupancy and Design of a Selective Inhibitor of Urokinase

A vector, pSHT, for the expression and secretion of protein domains in mammalian cells

Inhibitor-resistant tissue-type plasminogen activator: an improved thrombolytic agent in vitro

Revisiting Catalysis by Chymotrypsin Family Serine Proteases Using Peptide Substrates and Inhibitors with Unnatural Main Chains

Converting Tissue-type Plasminogen Activator into a Zymogen

Substrate specificity of tissue type plasminogen activator. Characterization of the fibrin independent specificity of t-PA for plasminogen

Distinguishing the specificities of closely related proteases. Role of P3 in substrate and inhibitor discrimination between tissue-type plasminogen activator and urokinase

Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer

Variants of Tissue-type Plasminogen Activator Which Display Substantially Enhanced Stimulation by Fibrin

Distinct Mechanisms Contribute to Stringent Substrate Specificity of Tissue-type Plasminogen Activator (∗)

Variants of Tissue-type Plasminogen Activator That Display Extraordinary Resistance to Inhibition by the Serpin Plasminogen Activator Inhibitor Type 1

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