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Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

Nature medicine, 2008-10, Vol.14 (10), p.1059-1066

2008

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Lipoprotein-associated phospholipase A2 and atherosclerosis

Current opinion in lipidology, 2009-10, Vol.20 (5), p.415-420

2009

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Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes

Cell chemical biology, 2019-11, Vol.26 (11), p.1559-1572.e9

2019

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Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo

Circulation (New York, N.Y.), 2006-01, Vol.113 (1), p.90-97

2006

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Diabetes and hypercholesterolemia increase blood-brain barrier permeability and brain amyloid deposition: beneficial effects of the LpPLA2 inhibitor darapladib

Journal of Alzheimer's disease, 2013-01, Vol.35 (1), p.179

2013

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Effect of darapladib treatment on endarterectomy carotid plaque lipoprotein-associated phospholipase A2 activity: a randomized, controlled trial

PloS one, 2014-02, Vol.9 (2), p.e89034

2014

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Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: results from an in vitro study and two randomized phase I trials

PloS one, 2014, Vol.9 (1), p.e83094

2014

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Electrospray Ionization Mass Spectrometry Identifies Substrates and Products of Lipoprotein-associated Phospholipase A2 in Oxidized Human Low Density Lipoprotein

The Journal of biological chemistry, 2008-03, Vol.283 (10), p.6428-6437

2008

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Lipoprotein-associated phospholipase A2 as a target of therapy

Current opinion in lipidology, 2005-08, Vol.16 (4), p.442-446

2005

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Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease

Atherosclerosis, 2000-06, Vol.150 (2), p.413-419

2000

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Synthetic LXR agonists increase LDL in CETP species

Journal of lipid research, 2005-10, Vol.46 (10), p.2182-2191

2005

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Lipoprotein-associated phospholipase A(2) and atherosclerosis

Current opinion in lipidology, 2009-10, Vol.20 (5), p.415-420

2009

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Diabetes status modifies the long-term effect of lipoprotein-associated phospholipase A2 on major coronary events

Diabetologia, 2022-01, Vol.65 (1), p.101-112

2022

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Inhibition of lipoprotein-associated phospholipase [A.sub.2] reduces complex coronary atherosclerotic plaque development

Nature medicine, 2008-10, Vol.14 (10), p.1059

2008

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Resistin is expressed in human macrophages and directly regulated by PPARγ activators

Biochemical and biophysical research communications, 2003-01, Vol.300 (2), p.472-476

2003

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Community-based statins and advanced carotid plaque: Role of CD163 positive macrophages in lipoprotein-associated phospholipase A2 activity in atherosclerotic plaque

Atherosclerosis, 2017-12, Vol.267, p.78-89

2017

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Retinal pathology is associated with increased blood–retina barrier permeability in a diabetic and hypercholesterolaemic pig model: Beneficial effects of the LpPLA2 inhibitor Darapladib

Diabetes & vascular disease research, 2017-05, Vol.14 (3), p.200-213

2017

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Discovery of Substituted Maleimides as Liver X Receptor Agonists and Determination of a Ligand-Bound Crystal Structure

Journal of medicinal chemistry, 2005-08, Vol.48 (17), p.5419-5422

2005

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Lipoprotein-Associated Phospholipase A2 as an Independent Predictor of Coronary Heart Disease

The New England journal of medicine, 2000-10, Vol.343 (16), p.1148-1155

2000

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Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells

Molecular and cellular biochemistry, 2007-01, Vol.295 (1-2), p.113-120

2007

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Rosiglitazone protects against ischemia/reperfusion-induced leukocyte adhesion in the zucker diabetic fatty rat

The Journal of pharmacology and experimental therapeutics, 2005-12, Vol.315 (3), p.1020

2005

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Purification, properties, sequencing, and cloning of a lipoprotein-associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins

Arteriosclerosis, thrombosis, and vascular biology, 1996-04, Vol.16 (4), p.591

1996

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Specificity of Lipoprotein-Associated Phospholipase A2 toward Oxidized Phosphatidylserines: Liquid Chromatography–Electrospray Ionization Mass Spectrometry Characterization of Products and Computer Modeling of Interactions

Biochemistry (Easton), 2012-12, Vol.51 (48), p.9736-9750

2012

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Specificity of lipoprotein-associated phospholipase A(2) toward oxidized phosphatidylserines: liquid chromatography-electrospray ionization mass spectrometry characterization of products and computer modeling of interactions

Biochemistry (Easton), 2012-12, Vol.51 (48), p.9736-9750

2012

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Role of lipoprotein-associated phospholipase A2 in atherosclerosis and its potential as a therapeutic target

Current opinion in pharmacology, 2006-04, Vol.6 (2), p.154-161

2006

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Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

Lipoprotein-associated phospholipase A2 and atherosclerosis

Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes

Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo

Diabetes and hypercholesterolemia increase blood-brain barrier permeability and brain amyloid deposition: beneficial effects of the LpPLA2 inhibitor darapladib

Effect of darapladib treatment on endarterectomy carotid plaque lipoprotein-associated phospholipase A2 activity: a randomized, controlled trial

Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: results from an in vitro study and two randomized phase I trials

Electrospray Ionization Mass Spectrometry Identifies Substrates and Products of Lipoprotein-associated Phospholipase A2 in Oxidized Human Low Density Lipoprotein

Lipoprotein-associated phospholipase A2 as a target of therapy

Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease

Synthetic LXR agonists increase LDL in CETP species

Lipoprotein-associated phospholipase A(2) and atherosclerosis

Diabetes status modifies the long-term effect of lipoprotein-associated phospholipase A2 on major coronary events

Inhibition of lipoprotein-associated phospholipase [A.sub.2] reduces complex coronary atherosclerotic plaque development

Resistin is expressed in human macrophages and directly regulated by PPARγ activators

Community-based statins and advanced carotid plaque: Role of CD163 positive macrophages in lipoprotein-associated phospholipase A2 activity in atherosclerotic plaque

Retinal pathology is associated with increased blood–retina barrier permeability in a diabetic and hypercholesterolaemic pig model: Beneficial effects of the LpPLA2 inhibitor Darapladib

Discovery of Substituted Maleimides as Liver X Receptor Agonists and Determination of a Ligand-Bound Crystal Structure

Lipoprotein-Associated Phospholipase A2 as an Independent Predictor of Coronary Heart Disease

Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells

Rosiglitazone protects against ischemia/reperfusion-induced leukocyte adhesion in the zucker diabetic fatty rat

Purification, properties, sequencing, and cloning of a lipoprotein-associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins

Specificity of Lipoprotein-Associated Phospholipase A2 toward Oxidized Phosphatidylserines: Liquid Chromatography–Electrospray Ionization Mass Spectrometry Characterization of Products and Computer Modeling of Interactions

Specificity of lipoprotein-associated phospholipase A(2) toward oxidized phosphatidylserines: liquid chromatography-electrospray ionization mass spectrometry characterization of products and computer modeling of interactions

Role of lipoprotein-associated phospholipase A2 in atherosclerosis and its potential as a therapeutic target

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