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Sustained efficacy and surface antigen seroconversion in the woodchuck model of chronic hepatitis B with the selective toll-like receptor 8 agonist GS-9688

Journal of hepatology, 2017, Vol.66 (1), p.S692-S693

2017

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In vitro and in vivo characterization of the selective toll-like receptor 8 agonist GS-9688

Journal of hepatology, 2017, Vol.66 (1), p.S694-S694

2017

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Development of Serine Protease Inhibitors Displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode: Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa

Journal of medicinal chemistry, 2001-08, Vol.44 (17), p.2753-2771

2001

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Exploiting Subsite S1 of Trypsin-Like Serine Proteases for Selectivity: Potent and Selective Inhibitors of Urokinase-Type Plasminogen Activator

Journal of medicinal chemistry, 2001-11, Vol.44 (23), p.3856-3871

2001

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Dissecting and Designing Inhibitor Selectivity Determinants at the S1 Site Using an Artificial Ala190 Protease (Ala190 uPA)

Journal of molecular biology, 2004-11, Vol.344 (2), p.527-547

2004

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CVT-313, a Specific and Potent Inhibitor of CDK2 That Prevents Neointimal Proliferation

The Journal of biological chemistry, 1997-11, Vol.272 (46), p.29207-29211

1997

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A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site

Journal of molecular biology, 2001-04, Vol.307 (5), p.1451-1486

2001

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SAT-165 - Sustained efficacy and surface antigen seroconversion in the woodchuck model of chronic hepatitis B with the selective toll-like receptor 8 agonist GS-9688

Journal of hepatology, 2017, Vol.66 (1), p.S692-S693

2017

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SAT-168 - In vitro and in vivo characterization of the selective toll-like receptor 8 agonist GS-9688

Journal of hepatology, 2017, Vol.66 (1), p.S694-S694

2017

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Synthesis and activity of 2,6,9-trisubstituted purines

Bioorganic & medicinal chemistry letters, 1997-11, Vol.7 (21), p.2697-2702

1997

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C105 ENVISIONING AND TESTING NEW THERAPEUTIC APPROACHES TO PNEUMONIA: A Phase 2a Study Demonstrates That Gs-5806 Safely Reduces Viral Load And Clinical Illness In Healthy Adult Volunteers Infected With Respiratory Syncytial Virus (rsv)

American journal of respiratory and critical care medicine, 2014-01, Vol.189, p.1

2014

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Relationship of active site topology to substrate specificity for cytochrome P450terp (CYP108)

The Journal of biological chemistry, 1994-11, Vol.269 (46), p.28815-28821

1994

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Active-Site Topology of Bovine Cholesterol Side-Chain Cleavage Cytochrome P450 (P450scc) and Evidence for Interaction of Tyrosine 94 with the Side Chain of Cholesterol

Archives of biochemistry and biophysics, 1995-09, Vol.322 (1), p.189-197

1995

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Low In Vitro Potential for Class-specific Toxicity of GS-9148, A Novel Nucleotide Reverse Transcriptase Inhibitor

Antiviral research, 2008-05, Vol.78 (2), p.A27-A27

2008

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Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors

Journal of molecular biology, 2003-05, Vol.329 (1), p.93-120

2003

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Contribution of Multicentered Short Hydrogen Bond Arrays to Potency of Active Site-Directed Serine Protease Inhibitors

Journal of the American Chemical Society, 2002-10, Vol.124 (39), p.11657-11668

2002

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Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets

Chemistry & biology, 2001-11, Vol.8 (11), p.1107-1121

2001

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2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

Bioorganic & medicinal chemistry letters, 2002-08, Vol.12 (15), p.2019-2022

2002

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4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

Bioorganic & medicinal chemistry letters, 2002-08, Vol.12 (15), p.2023-2026

2002

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Active-Site Topologies of Human CYP2D6 and Its Aspartate-301 → Glutamate, Asparagine, and Glycine Mutants

Archives of biochemistry and biophysics, 1996-07, Vol.331 (1), p.134-140

1996

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Design and synthesis of β-amino-α-hydroxy amide derivatives as inhibitors of MetAP2 and HUVEC growth

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3181-3184

2004

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Prodrug Strategies in the Design of Nucleoside and Nucleotide Antiviral Therapeutics

Annual Reports in Medicinal Chemistry, 2004, Vol.39, p.305-321

2004

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Active Site Topology of Human Cytochrome P450 2E1

Chemical research in toxicology, 1996-01, Vol.9 (1), p.223-226

1996

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Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator

Chemistry & biology, 2000-04, Vol.7 (4), p.299-312

2000

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Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Science translational medicine, 2017-06, Vol.9 (396)

2017

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Sustained efficacy and surface antigen seroconversion in the woodchuck model of chronic hepatitis B with the selective toll-like receptor 8 agonist GS-9688

In vitro and in vivo characterization of the selective toll-like receptor 8 agonist GS-9688

Development of Serine Protease Inhibitors Displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode: Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa

Exploiting Subsite S1 of Trypsin-Like Serine Proteases for Selectivity: Potent and Selective Inhibitors of Urokinase-Type Plasminogen Activator

Dissecting and Designing Inhibitor Selectivity Determinants at the S1 Site Using an Artificial Ala190 Protease (Ala190 uPA)

CVT-313, a Specific and Potent Inhibitor of CDK2 That Prevents Neointimal Proliferation

A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site

SAT-165 - Sustained efficacy and surface antigen seroconversion in the woodchuck model of chronic hepatitis B with the selective toll-like receptor 8 agonist GS-9688

SAT-168 - In vitro and in vivo characterization of the selective toll-like receptor 8 agonist GS-9688

Synthesis and activity of 2,6,9-trisubstituted purines

C105 ENVISIONING AND TESTING NEW THERAPEUTIC APPROACHES TO PNEUMONIA: A Phase 2a Study Demonstrates That Gs-5806 Safely Reduces Viral Load And Clinical Illness In Healthy Adult Volunteers Infected With Respiratory Syncytial Virus (rsv)

Relationship of active site topology to substrate specificity for cytochrome P450terp (CYP108)

Active-Site Topology of Bovine Cholesterol Side-Chain Cleavage Cytochrome P450 (P450scc) and Evidence for Interaction of Tyrosine 94 with the Side Chain of Cholesterol

Low In Vitro Potential for Class-specific Toxicity of GS-9148, A Novel Nucleotide Reverse Transcriptase Inhibitor

Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors

Contribution of Multicentered Short Hydrogen Bond Arrays to Potency of Active Site-Directed Serine Protease Inhibitors

Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets

2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

Active-Site Topologies of Human CYP2D6 and Its Aspartate-301 → Glutamate, Asparagine, and Glycine Mutants

Design and synthesis of β-amino-α-hydroxy amide derivatives as inhibitors of MetAP2 and HUVEC growth

Prodrug Strategies in the Design of Nucleoside and Nucleotide Antiviral Therapeutics

Active Site Topology of Human Cytochrome P450 2E1

Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

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