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LGALS1 acts as a pro-survival molecule in AML

Biochimica et biophysica acta. Molecular cell research, 2020-10, Vol.1867 (10), p.118785-118785, Article 118785

2020

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Targeting the NOTCH1-MYC-CD44 axis in leukemia-initiating cells in T-ALL

Leukemia, 2022-05, Vol.36 (5), p.1261-1273

2022

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AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3-ITD acute myeloid leukemia

Haematologica (Roma), 2022-06, Vol.107 (6), p.1311-1322

2022

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Uncovering the Role of RNA-Binding Protein hnRNP K in B-Cell Lymphomas

JNCI : Journal of the National Cancer Institute, 2020-01, Vol.112 (1), p.95-106

2020

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Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms

Haematologica (Roma), 2017-12, Vol.102 (12), p.2048-2057

2017

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N-Acetylcysteine protects against trichloroethene-mediated autoimmunity by attenuating oxidative stress

Toxicology and applied pharmacology, 2013-11, Vol.273 (1), p.189-195

2013

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Mcl-1/CDK9 Targeting By AZD5991/AZD4573 Overcomes Intrinsic and Acquired Venetoclax Resistance in Vitro and In Vivo in PDX Model of AML through Modulation of Cell Death and Metabolic Functions

Blood, 2018-11, Vol.132 (Supplement 1), p.768-768

2018

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Increased nitration and carbonylation of proteins in MRL +/+ mice exposed to trichloroethene: Potential role of protein oxidation in autoimmunity

Toxicology and applied pharmacology, 2009-06, Vol.237 (2), p.188-195

2009

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Enhanced expression of cyclins and cyclin-dependent kinases in aniline-induced cell proliferation in rat spleen

Toxicology and applied pharmacology, 2011-01, Vol.250 (2), p.213-220

2011

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Oxidative DNA damage and its repair in rat spleen following subchronic exposure to aniline

Toxicology and applied pharmacology, 2008-12, Vol.233 (2), p.247-253

2008

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Induction of base excision repair enzymes NTH1 and APE1 in rat spleen following aniline exposure

Toxicology and applied pharmacology, 2013-03, Vol.267 (3), p.276-283

2013

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Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity

Toxicology and applied pharmacology, 2011-02, Vol.251 (1), p.1-7

2011

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Investigating the Impact of Smoking Traditional and E-Cigarettes on Acute Myeloid Leukemia Progression

Blood, 2023-11, Vol.142 (Supplement 1), p.5702-5702

2023

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Differential modulation of base excision repair activities during brain ontogeny: Implications for repair of transcribed DNA

Mechanisms of ageing and development, 2006, Vol.127 (1), p.64-69

2006

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Contribution of poly(ADP-ribose)polymerase-1 activation and apoptosis in trichloroethene-mediated autoimmunity

Toxicology and applied pharmacology, 2019-01, Vol.362, p.28-34

2019

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Inhibition of Cyclin Dependent Kinase 8(CDK8): A Novel Approach to Target the Leukemia Initiating Cells (LICs) in T-Cell Acute Lymphoblastic Leukaemia (T-ALL)

Blood, 2021-11, Vol.138 (Supplement 1), p.2250-2250

2021

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ERK1/2 Inhibition Overcomes Resistance in Acute Myeloid Leukemia (AML) and Alters Mitochondrial Dynamics

Blood, 2021-11, Vol.138 (Supplement 1), p.3338-3338

2021

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Inhibition of De Novo Pyrimidine Synthesis Depletes Acute Myleogenous Leukemia Stem Cells (LSCs) Burden and Triggers Apoptosis and Differentiation Associated with Oxidative Stress

Blood, 2021-11, Vol.138 (Supplement 1), p.2249-2249

2021

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IL15 Expressing CD123-Targeted Engager T-Cell Therapy for Adult Acute Myeloid Leukemia

Blood, 2018-11, Vol.132 (Supplement 1), p.2724-2724

2018

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The Novel Dihydroorotate Dehydrogenase (DHODH) Inhibitor PTC299 Inhibit De Novo Pyrimidine Synthesis with Broad Anti-Leukemic Activity Against Acute Myeloid Leukemia

Blood, 2020-11, Vol.136 (Supplement 1), p.8-9

2020

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Targeting Unc51-like Autophagy Activating Kinase 1 (ULK1) Overcomes Adaptive Drug Resistance in Acute Myelogenous Leukemia

Molecular cancer research, 2023-06, Vol.21 (6), p.548-563

2023

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Combination Therapy with BTK Inhibitor Plus Anti-PD-1 Antibody Results in a Hyperprogressor Phenotype in a Mouse Model of CLL

Blood, 2018-11, Vol.132 (Supplement 1), p.4416-4416

2018

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AML-044: LGALS1 Acts as a Pro-Survival Molecule in AML

Clinical lymphoma, myeloma and leukemia, 2020-09, Vol.20, p.S176-S177

2020

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TAM Inhibitor ONO-7475 Combination with Sorafenib Is Effective Using in Vitro and In Vivo Models of FLT3 ITD Acute Myeloid Leukemia

Blood, 2018-11, Vol.132 (Supplement 1), p.2642-2642

2018

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AXL/Mertk Inhibitor ONO-7475 Potently Synergizes with BCL2 Inhibitor ABT-199, Overcomes ABT-199 Resistance Mechanisms, and Kills FLT3 ITD AML Cells

Blood, 2019-11, Vol.134 (Supplement_1), p.2550-2550

2019

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LGALS1 acts as a pro-survival molecule in AML

Targeting the NOTCH1-MYC-CD44 axis in leukemia-initiating cells in T-ALL

AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3-ITD acute myeloid leukemia

Uncovering the Role of RNA-Binding Protein hnRNP K in B-Cell Lymphomas

Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms

N-Acetylcysteine protects against trichloroethene-mediated autoimmunity by attenuating oxidative stress

Mcl-1/CDK9 Targeting By AZD5991/AZD4573 Overcomes Intrinsic and Acquired Venetoclax Resistance in Vitro and In Vivo in PDX Model of AML through Modulation of Cell Death and Metabolic Functions

Increased nitration and carbonylation of proteins in MRL +/+ mice exposed to trichloroethene: Potential role of protein oxidation in autoimmunity

Enhanced expression of cyclins and cyclin-dependent kinases in aniline-induced cell proliferation in rat spleen

Oxidative DNA damage and its repair in rat spleen following subchronic exposure to aniline

Induction of base excision repair enzymes NTH1 and APE1 in rat spleen following aniline exposure

Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity

Investigating the Impact of Smoking Traditional and E-Cigarettes on Acute Myeloid Leukemia Progression

Differential modulation of base excision repair activities during brain ontogeny: Implications for repair of transcribed DNA

Contribution of poly(ADP-ribose)polymerase-1 activation and apoptosis in trichloroethene-mediated autoimmunity

Inhibition of Cyclin Dependent Kinase 8(CDK8): A Novel Approach to Target the Leukemia Initiating Cells (LICs) in T-Cell Acute Lymphoblastic Leukaemia (T-ALL)

ERK1/2 Inhibition Overcomes Resistance in Acute Myeloid Leukemia (AML) and Alters Mitochondrial Dynamics

Inhibition of De Novo Pyrimidine Synthesis Depletes Acute Myleogenous Leukemia Stem Cells (LSCs) Burden and Triggers Apoptosis and Differentiation Associated with Oxidative Stress

IL15 Expressing CD123-Targeted Engager T-Cell Therapy for Adult Acute Myeloid Leukemia

The Novel Dihydroorotate Dehydrogenase (DHODH) Inhibitor PTC299 Inhibit De Novo Pyrimidine Synthesis with Broad Anti-Leukemic Activity Against Acute Myeloid Leukemia

Targeting Unc51-like Autophagy Activating Kinase 1 (ULK1) Overcomes Adaptive Drug Resistance in Acute Myelogenous Leukemia

Combination Therapy with BTK Inhibitor Plus Anti-PD-1 Antibody Results in a Hyperprogressor Phenotype in a Mouse Model of CLL

AML-044: LGALS1 Acts as a Pro-Survival Molecule in AML

TAM Inhibitor ONO-7475 Combination with Sorafenib Is Effective Using in Vitro and In Vivo Models of FLT3 ITD Acute Myeloid Leukemia

AXL/Mertk Inhibitor ONO-7475 Potently Synergizes with BCL2 Inhibitor ABT-199, Overcomes ABT-199 Resistance Mechanisms, and Kills FLT3 ITD AML Cells

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