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A Tailored Therapy for the Metabolic Syndrome

Diabetes (New York, N.Y.), 2002-04, Vol.51 (4), p.1083-1087

2002

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Structural basis for GPR40 allosteric agonism and incretin stimulation

Nature communications, 2018-04, Vol.9 (1), p.1645-11, Article 1645

2018

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Discovery of 6‑(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl‑1H‑indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia

Journal of medicinal chemistry, 2015-12, Vol.58 (24), p.9768-9772

2015

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A Novel Aldosterone Antagonist Limits Renal Injury in 5/6 Nephrectomy

Scientific reports, 2017-08, Vol.7 (1), p.7899-12, Article 7899

2017

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Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method

Proceedings of the National Academy of Sciences - PNAS, 2008-05, Vol.105 (20), p.7171-7176

2008

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The Hypolipidemic Natural Product Guggulsterone Is a Promiscuous Steroid Receptor Ligand

Molecular pharmacology, 2005-03, Vol.67 (3), p.948-954

2005

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A nonsecosteroidal vitamin D receptor ligand with improved therapeutic window of bone efficacy over hypercalcemia

Journal of bone and mineral research, 2010-06, Vol.25 (6), p.1326-1336

2010

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Unique Ligand Binding Patterns between Estrogen Receptor α and β Revealed by Hydrogen−Deuterium Exchange

Biochemistry (Easton), 2009-10, Vol.48 (40), p.9668-9676

2009

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Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1 H -indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia

Journal of medicinal chemistry, 2015-12, Vol.58 (24), p.9768-9772

2015

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Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptor β agonists

Bioorganic & medicinal chemistry letters, 2015-04, Vol.25 (7), p.1377-1380

2015

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A natural product ligand of the oxysterol receptor, liver X receptor

The Journal of pharmacology and experimental therapeutics, 2003-10, Vol.307 (1), p.291

2003

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A Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist with a Unique in Vitro Profile and Potent Glucose and Lipid Effects in Rodent Models of Type 2 Diabetes and Dyslipidemia

Molecular endocrinology (Baltimore, Md.), 2005-06, Vol.19 (6), p.1593-1605

2005

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2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents

Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (1), p.51-55

2005

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Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

Journal of medicinal chemistry, 2003-11, Vol.46 (24), p.5121-5124

2003

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Hydrophobic Interactions Improve Selectivity to ERα for Benzothiophene SERMs

ACS medicinal chemistry letters, 2012-03, Vol.3 (3), p.207-210

2012

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Design, Synthesis, and Structure−Activity Relationship Studies of Novel 6,7-Locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids

Journal of medicinal chemistry, 2003-09, Vol.46 (19), p.4087-4103

2003

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Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats

The Journal of clinical investigation, 1997-06, Vol.99 (12), p.2883-2889

1997

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Identification of a novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl}phenoxy)propanoic acid (LY518674), that produces marked changes in serum lipids and apolipoprotein A-1 expression

Molecular pharmacology, 2005-09, Vol.68 (3), p.763-768

2005

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Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/γ Agonists

Journal of medicinal chemistry, 2004-05, Vol.47 (10), p.2422-2425

2004

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Hydrophobic Interactions Improve Selectivity to ERα for Ben-zothiophene SERMs

ACS medicinal chemistry letters, 2012-03, Vol.3 (3), p.207-210

2012

Volltextzugriff (PDF)

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A tailored therapy for the metabolic syndrome: The dual peroxisome proliferator-activated receptor-α/γ agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in preclinical models

A Tailored Therapy for the Metabolic Syndrome

A tailored therapy for the metabolic syndrome: the dual peroxisome proliferator-activated receptor-αγ agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in preclinical models

Structural basis for GPR40 allosteric agonism and incretin stimulation

Discovery of 6‑(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl‑1H‑indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia

A Novel Aldosterone Antagonist Limits Renal Injury in 5/6 Nephrectomy

Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method

The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470)

Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus

The Hypolipidemic Natural Product Guggulsterone Is a Promiscuous Steroid Receptor Ligand

A nonsecosteroidal vitamin D receptor ligand with improved therapeutic window of bone efficacy over hypercalcemia

Unique Ligand Binding Patterns between Estrogen Receptor α and β Revealed by Hydrogen−Deuterium Exchange

Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1 H -indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia

Biological Characterization of a Heterodimer-Selective Retinoid X Receptor Modulator: Potential Benefits for the Treatment of Type 2 Diabetes

Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptor β agonists

A natural product ligand of the oxysterol receptor, liver X receptor

A Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist with a Unique in Vitro Profile and Potent Glucose and Lipid Effects in Rodent Models of Type 2 Diabetes and Dyslipidemia

2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents

Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

Hydrophobic Interactions Improve Selectivity to ERα for Benzothiophene SERMs

Design, Synthesis, and Structure−Activity Relationship Studies of Novel 6,7-Locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids

Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats

Identification of a novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl}phenoxy)propanoic acid (LY518674), that produces marked changes in serum lipids and apolipoprotein A-1 expression

Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/γ Agonists

Hydrophobic Interactions Improve Selectivity to ERα for Ben-zothiophene SERMs

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