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Werner Syndrome: Clinical Features, Pathogenesis and Potential Therapeutic Interventions

Ageing research reviews, 2017-01, Vol.33, p.105-114

2017

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Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

Nature cell biology, 2007-06, Vol.9 (6), p.683-690

2007

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Tumour predisposition and cancer syndromes as models to study gene-environment interactions

Nature reviews. Cancer, 2020-09, Vol.20 (9), p.533-549

2020

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Spectrum and risk of neoplasia in Werner syndrome: a systematic review

PloS one, 2013-04, Vol.8 (4), p.e59709-e59709

2013

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Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

Nature structural & molecular biology, 2013-03, Vol.20 (3), p.347-354

2013

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DNA polymerases and human disease

Nature reviews. Drug discovery, 2008-08, Vol.9 (8), p.594-604

2008

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High‐throughput, microscope‐based sorting to dissect cellular heterogeneity

Molecular systems biology, 2020-06, Vol.16 (6), p.e9442-n/a

2020

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A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

Nature (London), 2011-05, Vol.473 (7346), p.212-215

2011

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Human RECQ1 and RECQ4 Helicases Play Distinct Roles in DNA Replication Initiation

Molecular and Cellular Biology, 2010-03, Vol.30 (6), p.1382-1396

2010

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James German and the Quest to Understand Human RECQ Helicase Deficiencies

Cells (Basel, Switzerland), 2024-06, Vol.13 (13), p.1077

Monnat, Jr, Raymond J

2024

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Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice

Blood, 2016-12, Vol.128 (24), p.2774-2784

2016

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Human RECQ helicases: Roles in DNA metabolism, mutagenesis and cancer biology

Seminars in cancer biology, 2010-10, Vol.20 (5), p.329-339

Monnat, Raymond J

2010

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The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription

Human molecular genetics, 2016-05, Vol.25 (10), p.2060-2069

2016

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Unsupervised discovery of dynamic cell phenotypic states from transmitted light movies

PLoS computational biology, 2021-12, Vol.17 (12), p.e1009626-e1009626

2021

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Computational redesign of endonuclease DNA binding and cleavage specificity

Nature, 2006-06, Vol.441 (7093), p.656-659

2006

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Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases

Nature reviews. Molecular cell biology, 2007-05, Vol.8 (5), p.394-404

2007

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Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (27), p.9905-9910

2014

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Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases

Ageing research reviews, 2018-01, Vol.41, p.82-97

2018

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Homologous Recombination Resolution Defect in Werner Syndrome

Molecular and Cellular Biology, 2002-10, Vol.22 (20), p.6971-6978

2002

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Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation

Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (22), p.8954-8959

2013

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The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

Cell cycle (Georgetown, Tex.), 2008-03, Vol.7 (6), p.796-807

2008

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A functional module states framework reveals transcriptional states for drug and target prediction

Cell reports (Cambridge), 2022-01, Vol.38 (3), p.110269-110269, Article 110269

2022

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“…Rewritten in the Skin”: Clues to Skin Biology and Aging from Inherited Disease

Journal of investigative dermatology, 2015-06, Vol.135 (6), p.1484-1490

Monnat, Raymond J.

2015

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Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease

Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (13), p.5099-5104

2009

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Fanconi anemia‐isogenic head and neck cancer cell line pairs: A basic and translational science resource

International journal of cancer, 2023-07, Vol.153 (1), p.183-196

2023

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Werner Syndrome: Clinical Features, Pathogenesis and Potential Therapeutic Interventions

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

Tumour predisposition and cancer syndromes as models to study gene-environment interactions

Spectrum and risk of neoplasia in Werner syndrome: a systematic review

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

DNA polymerases and human disease

High‐throughput, microscope‐based sorting to dissect cellular heterogeneity

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

Human RECQ1 and RECQ4 Helicases Play Distinct Roles in DNA Replication Initiation

James German and the Quest to Understand Human RECQ Helicase Deficiencies

Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice

Human RECQ helicases: Roles in DNA metabolism, mutagenesis and cancer biology

The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription

Unsupervised discovery of dynamic cell phenotypic states from transmitted light movies

Computational redesign of endonuclease DNA binding and cleavage specificity

Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases

Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs

Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases

Homologous Recombination Resolution Defect in Werner Syndrome

Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

A functional module states framework reveals transcriptional states for drug and target prediction

“…Rewritten in the Skin”: Clues to Skin Biology and Aging from Inherited Disease

Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease

Fanconi anemia‐isogenic head and neck cancer cell line pairs: A basic and translational science resource

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