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Concentration‐QTc modeling of sitravatinib in patients with advanced solid malignancies

Clinical and translational science, 2024-05, Vol.17 (5), p.e13808-n/a

2024

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Pharmacokinetic and Pharmacodynamic Modeling To Determine the Dose of ST-246 To Protect against Smallpox in Humans

Antimicrobial Agents and Chemotherapy, 2013-03, Vol.57 (3), p.1136-1143

2013

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Clinical Trial Simulations in Pediatric Patients Using Realistic Covariates: Application to Teduglutide, a Glucagon-Like Peptide-2 Analog in Neonates and Infants With Short-Bowel Syndrome

Clinical pharmacology and therapeutics, 2009-12, Vol.86 (6), p.667-671

2009

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Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: Safety, pharmacokinetics and ammonia control

Molecular genetics and metabolism, 2010-07, Vol.100 (3), p.221-228

2010

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Phase I safety, pharmacokinetic and pharmacodynamic trial of BMS-599626 (AC480), an oral pan-HER receptor tyrosine kinase inhibitor, in patients with advanced solid tumors

Annals of oncology, 2012-02, Vol.23 (2), p.463-471

2012

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Modeling and Experimental Studies of Obeticholic Acid Exposure and the Impact of Cirrhosis Stage

Clinical and translational science, 2016-12, Vol.9 (6), p.328-336

2016

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A randomized, double‐blind, placebo‐controlled, pharmacokinetic and pharmacodynamic study of a fixed‐dose combination of phentermine/topiramate in adolescents with obesity

Diabetes, obesity & metabolism, 2020-04, Vol.22 (4), p.480-491

2020

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Population Pharmacokinetics and Exposure‐Response Analyses for CPX‐351 in Patients With Hematologic Malignancies

Journal of clinical pharmacology, 2019-05, Vol.59 (5), p.748-762

2019

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Pharmacokinetics and anesthetic activity of eugenol in male Sprague-Dawley rats

Journal of veterinary pharmacology and therapeutics, 2006-08, Vol.29 (4), p.265-270

2006

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Population Pharmacokinetics and Pharmacodynamics of SHP647, a Fully Human Monoclonal Antibody Against Mucosal Addressin Cell Adhesion Molecule-1 (anti-MAdCAM-1), in Patients With Ulcerative Colitis or Crohnʼs Disease: 704

The American journal of gastroenterology, 2018-10, Vol.113 (Supplement), p.S396-S397

2018

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A randomized, open-label, multicenter, phase II study evaluating the efficacy and safety of BTH1677 (1,3–1,6 beta glucan; Imprime PGG) in combination with cetuximab and chemotherapy in patients with advanced non-small cell lung cancer

Investigational new drugs, 2017-06, Vol.35 (3), p.345-358

2017

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Modeling and simulation for medical product development and evaluation: highlights from the FDA-C-Path-ISOP 2013 workshop

Journal of pharmacokinetics and pharmacodynamics, 2014-12, Vol.41 (6), p.545-552

2014

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Liposomal tobramycin against pulmonary infections of Pseudomonas aeruginosa: a pharmacokinetic and efficacy study following single and multiple intratracheal administrations in rats

Journal of antimicrobial chemotherapy, 2003-08, Vol.52 (2), p.247-252

2003

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Population pharmacokinetic and pharmacodynamic analyses from a 4-month intradose escalation and its subsequent 12-month dose titration studies for a human monoclonal anti-FGF23 antibody (KRN23) in adults with X-linked hypophosphatemia

Journal of clinical pharmacology, 2016-04, Vol.56 (4), p.429-438

2016

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Phase I safety, pharmacokinetic and pharmacodynamic trial of BMS-599626 (AC480), an oral pan-HER receptor tyrosine kinase inhibitor, in patients with advanced solid tumors

Annals of oncology, 2019-06, Vol.30 (6), p.1020-1020

2019

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Ammonia control in children with urea cycle disorders (UCDs); Phase 2 comparison of sodium phenylbutyrate and glycerol phenylbutyrate

Molecular genetics and metabolism, 2011-08, Vol.103 (4), p.323-329

2011

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Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model

The Journal of pharmacology and experimental therapeutics, 2002-07, Vol.302 (1), p.369

2002

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The effect of plasmapheresis on blood pressure in voluntary plasma donors

Vox sanguinis, 2015-01, Vol.108 (1), p.11-17

2015

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A pharmacokinetic study of amoxycillin in febrile beagle dogs following repeated administrations of endotoxin

Journal of veterinary pharmacology and therapeutics, 2001-12, Vol.24 (6), p.379-383

2001

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Comparative bioavailability of a generic capsule formulation of the reverse transcriptase inhibitor efavirenz and the innovator product

International journal of clinical pharmacology and therapeutics, 2006-04, Vol.44 (4), p.180

2006

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Pharmacokinetics of Lamivudine, Zidovudine, and Nevirapine Administered as a Fixed-Dose Combination Formulation Versus Coadministration of the Individual Products

Journal of clinical pharmacology, 2007-11, Vol.47 (11), p.1381-1389

2007

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Influence of concomitant quinidine administration on dextromethorphan disposition in rats

Journal of veterinary pharmacology and therapeutics, 2004-04, Vol.27 (2), p.111-114

2004

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P069 ONTAMALIMAB, A FULLY HUMAN MONOCLONAL ANTIBODY AGAINST MUCOSAL ADDRESSIN CELL ADHESION MOLECULE-1, PROVIDES SUSTAINED EXPOSURE FOLLOWING LONG-TERM TREATMENT IN PATIENTS WITH ULCERATIVE COLITIS

Inflammatory bowel diseases, 2020-01, Vol.26 (Supplement_1), p.S11-S11

2020

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Tutorial: Evaluation of Covariate Effects using Forest Plots and Introduction to the coveffectsplot R package

CPT: pharmacometrics and systems pharmacology, 2022-06

2022

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Stereoselective disposition of propranolol in rabbits. Role of presystemic organs and dose

Drug metabolism and disposition, 1998-02, Vol.26 (2), p.164

1998

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Concentration‐QTc modeling of sitravatinib in patients with advanced solid malignancies

Pharmacokinetic and Pharmacodynamic Modeling To Determine the Dose of ST-246 To Protect against Smallpox in Humans

Clinical Trial Simulations in Pediatric Patients Using Realistic Covariates: Application to Teduglutide, a Glucagon-Like Peptide-2 Analog in Neonates and Infants With Short-Bowel Syndrome

Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: Safety, pharmacokinetics and ammonia control

Phase I safety, pharmacokinetic and pharmacodynamic trial of BMS-599626 (AC480), an oral pan-HER receptor tyrosine kinase inhibitor, in patients with advanced solid tumors

Modeling and Experimental Studies of Obeticholic Acid Exposure and the Impact of Cirrhosis Stage

A randomized, double‐blind, placebo‐controlled, pharmacokinetic and pharmacodynamic study of a fixed‐dose combination of phentermine/topiramate in adolescents with obesity

Population Pharmacokinetics and Exposure‐Response Analyses for CPX‐351 in Patients With Hematologic Malignancies

Pharmacokinetics and anesthetic activity of eugenol in male Sprague-Dawley rats

Population Pharmacokinetics and Pharmacodynamics of SHP647, a Fully Human Monoclonal Antibody Against Mucosal Addressin Cell Adhesion Molecule-1 (anti-MAdCAM-1), in Patients With Ulcerative Colitis or Crohnʼs Disease: 704

A randomized, open-label, multicenter, phase II study evaluating the efficacy and safety of BTH1677 (1,3–1,6 beta glucan; Imprime PGG) in combination with cetuximab and chemotherapy in patients with advanced non-small cell lung cancer

Modeling and simulation for medical product development and evaluation: highlights from the FDA-C-Path-ISOP 2013 workshop

Liposomal tobramycin against pulmonary infections of Pseudomonas aeruginosa: a pharmacokinetic and efficacy study following single and multiple intratracheal administrations in rats

Population pharmacokinetic and pharmacodynamic analyses from a 4-month intradose escalation and its subsequent 12-month dose titration studies for a human monoclonal anti-FGF23 antibody (KRN23) in adults with X-linked hypophosphatemia

Phase I safety, pharmacokinetic and pharmacodynamic trial of BMS-599626 (AC480), an oral pan-HER receptor tyrosine kinase inhibitor, in patients with advanced solid tumors

Ammonia control in children with urea cycle disorders (UCDs); Phase 2 comparison of sodium phenylbutyrate and glycerol phenylbutyrate

Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model

The effect of plasmapheresis on blood pressure in voluntary plasma donors

A pharmacokinetic study of amoxycillin in febrile beagle dogs following repeated administrations of endotoxin

Comparative bioavailability of a generic capsule formulation of the reverse transcriptase inhibitor efavirenz and the innovator product

Pharmacokinetics of Lamivudine, Zidovudine, and Nevirapine Administered as a Fixed-Dose Combination Formulation Versus Coadministration of the Individual Products

Influence of concomitant quinidine administration on dextromethorphan disposition in rats

P069 ONTAMALIMAB, A FULLY HUMAN MONOCLONAL ANTIBODY AGAINST MUCOSAL ADDRESSIN CELL ADHESION MOLECULE-1, PROVIDES SUSTAINED EXPOSURE FOLLOWING LONG-TERM TREATMENT IN PATIENTS WITH ULCERATIVE COLITIS

Tutorial: Evaluation of Covariate Effects using Forest Plots and Introduction to the coveffectsplot R package

Stereoselective disposition of propranolol in rabbits. Role of presystemic organs and dose

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