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ADX106772, an mGlu2 receptor positive allosteric modulator, selectively attenuates oxycodone taking and seeking

Neuropharmacology, 2023-11, Vol.238, p.109666-109666, Article 109666

2023

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Gene Expression Evidence for Remodeling of Lateral Hypothalamic Circuitry in Cocaine Addiction

Proceedings of the National Academy of Sciences - PNAS, 2005-08, Vol.102 (32), p.11533-11538

2005

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ERK regulation in chronic ethanol exposure and withdrawal

Brain research, 2002-09, Vol.948 (1), p.186-191

2002

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Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage

Molecular brain, 2015-10, Vol.8 (1), p.66-66, Article 66

2015

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Recent advances in drug discovery of GPCR allosteric modulators for neurodegenerative disorders

Current opinion in pharmacology, 2017-02, Vol.32, p.91-95

2017

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Lateral allosterism in the glucagon receptor family: glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation

Molecular pharmacology, 2012-03, Vol.81 (3), p.309-318

2012

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mGluR5 negative allosteric modulators overview: a medicinal chemistry approach towards a series of novel therapeutic agents

Current topics in medicinal chemistry, 2011-03, Vol.11 (6), p.680

2011

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Rescue of striatal long-term depression by chronic MGLU5 receptor negative allosteric modulation in distinct dystonia models

Journal of the neurological sciences, 2021-10, Vol.429, p.119476, Article 119476

2021

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Effect of the Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulator Dipraglurant on Motor and Non-Motor Symptoms of Parkinson's Disease

Cells (Basel, Switzerland), 2023-03, Vol.12 (7), p.1004

2023

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Localization and targeting of SCG10 to the trans-Golgi apparatus and growth cone vesicles

The European journal of neuroscience, 2000-07, Vol.12 (7), p.2224-2234

2000

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Discovery of 1‑Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)‑pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

Journal of medicinal chemistry, 2014-08, Vol.57 (15), p.6495-6512

2014

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Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782

The Journal of pharmacology and experimental therapeutics, 2013-09, Vol.346 (3), p.514

2013

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Targeting of SCG10 to the Area of the Golgi Complex Is Mediated by Its NH2-terminal Region

The Journal of biological chemistry, 1997-02, Vol.272 (8), p.5175-5182

1997

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Phosphatidylinositol 3-Kinase Is Required for the Expression But Not for the Induction or the Maintenance of Long-Term Potentiation in the Hippocampal CA1 Region

The Journal of neuroscience, 2002-05, Vol.22 (9), p.3359-3365

2002

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Differential distribution of stathmin and SCG10 in developing neurons in culture

Journal of neuroscience research, 1997-12, Vol.50 (6), p.1000-1009

1997

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Discovery of 1,4-Disubstituted 3-Cyano-2-pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.2388-2405

2012

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Increased expression of protein kinase A inhibitor α (PKI-α) and decreased PKA-regulated genes in chronic intermittent alcohol exposure

Brain research, 2007-03, Vol.1138, p.48-56

2007

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Regulation of Microtubule Dynamics by the Neuronal Growth-Associated Protein SCG10

Proceedings of the National Academy of Sciences - PNAS, 1997-01, Vol.94 (2), p.741-745

1997

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New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (3), p.971-976

2011

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Identification of in Vitro Phosphorylation Sites in the Growth Cone Protein SCG10

The Journal of biological chemistry, 1998-04, Vol.273 (14), p.8439-8446

1998

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CHAPTER 10 - Glutamate Receptor Modulators as Emergent Therapeutic Agents in the Treatment of Parkinson’s Disease

Emerging Drugs and Targets for Parkinson's Disease, 2013, p.237-265

2013

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Identification of in vitro phosphorylation sites in the growth cone protein SCG10. Effect Of phosphorylation site mutants on microtubule-destabilizing activity

The Journal of biological chemistry, 1998-04, Vol.273 (14), p.8439-8446

1998

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The drug candidate, ADX71441, is a novel, potent and selective positive allosteric modulator of the GABAB receptor with a potential for treatment of anxiety, pain and spasticity

Neuropharmacology, 2017-03, Vol.114, p.34-47

2017

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ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization

The Journal of pharmacology and experimental therapeutics, 2013-03, Vol.344 (3), p.624

2013

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ADX106772, an mGlu2 receptor positive allosteric modulator, selectively attenuates oxycodone taking and seeking

Gene Expression Evidence for Remodeling of Lateral Hypothalamic Circuitry in Cocaine Addiction

ERK regulation in chronic ethanol exposure and withdrawal

Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage

Recent advances in drug discovery of GPCR allosteric modulators for neurodegenerative disorders

Lateral allosterism in the glucagon receptor family: glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation

mGluR5 negative allosteric modulators overview: a medicinal chemistry approach towards a series of novel therapeutic agents

Rescue of striatal long-term depression by chronic MGLU5 receptor negative allosteric modulation in distinct dystonia models

Effect of the Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulator Dipraglurant on Motor and Non-Motor Symptoms of Parkinson's Disease

Localization and targeting of SCG10 to the trans-Golgi apparatus and growth cone vesicles

Discovery of 1‑Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)‑pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782

Targeting of SCG10 to the Area of the Golgi Complex Is Mediated by Its NH2-terminal Region

Phosphatidylinositol 3-Kinase Is Required for the Expression But Not for the Induction or the Maintenance of Long-Term Potentiation in the Hippocampal CA1 Region

Differential distribution of stathmin and SCG10 in developing neurons in culture

Discovery of 1,4-Disubstituted 3-Cyano-2-pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

Increased expression of protein kinase A inhibitor α (PKI-α) and decreased PKA-regulated genes in chronic intermittent alcohol exposure

Regulation of Microtubule Dynamics by the Neuronal Growth-Associated Protein SCG10

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones

Identification of in Vitro Phosphorylation Sites in the Growth Cone Protein SCG10

CHAPTER 10 - Glutamate Receptor Modulators as Emergent Therapeutic Agents in the Treatment of Parkinson’s Disease

Identification of in vitro phosphorylation sites in the growth cone protein SCG10. Effect Of phosphorylation site mutants on microtubule-destabilizing activity

The drug candidate, ADX71441, is a novel, potent and selective positive allosteric modulator of the GABAB receptor with a potential for treatment of anxiety, pain and spasticity

Discovery of 1,5-Disubstituted Pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization

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