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Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

Nucleic acids research, 2011-11, Vol.39 (21), p.e142-e142

2011

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Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

Molecular therapy, 2008-11, Vol.16 (11), p.1833-1840

2008

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Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

Nature immunology, 2015-10, Vol.16 (10), p.1025-1033

2015

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Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing

Methods (San Diego, Calif.), 2008, Vol.44 (1), p.3-12

2008

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RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries

RNA (Cambridge), 2011-09, Vol.17 (9), p.1697-1712

2011

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Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

Immunity (Cambridge, Mass.), 2009-07, Vol.31 (1), p.25-34

2009

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NUDT2 initiates viral RNA degradation by removal of 5′-phosphates

Nature communications, 2021-11, Vol.12 (1), p.6918-6918, Article 6918

2021

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Ribozyme Assays to Quantify the Capping Efficiency of In Vitro-Transcribed mRNA

Pharmaceutics, 2022-01, Vol.14 (2), p.328

2022

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RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation

Cancer immunology research, 2017-06, Vol.5 (6), p.455-467

2017

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cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

Nature (London), 2013-06, Vol.498 (7454), p.380-384

2013

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A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2′O-Methylated Self RNA

Immunity (Cambridge, Mass.), 2015-07, Vol.43 (1), p.41-51

2015

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Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self-DNA based on CpG-specific recognition of phosphodiester DNA

Journal of leukocyte biology, 2009-09, Vol.86 (3), p.663-670

2009

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Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

Nature (London), 2014-10, Vol.514 (7522), p.372-375

2014

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A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA

Immunity (Cambridge, Mass.), 2015-07, Vol.43 (1), p.41-51

2015

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Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I

Nature structural & molecular biology, 2010-07, Vol.17 (7), p.781-787

2010

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miRNA in situ hybridization in formaldehyde and EDC-fixed tissues

Nature methods, 2009-02, Vol.6 (2), p.139-141

2009

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A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA

Nucleic acids research, 2023-11, Vol.51 (21), p.11893-11910

2023

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Differential gene expression profile analysis of RIG-I- versus type I IFN-stimulated primary human nasal epithelial cells and protection from influenza virus replication

The Journal of immunology (1950), 2019-05, Vol.202 (1_Supplement), p.198-198.12

2019

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Hammerhead ribozymes with cleavage site specificity for NUH and NCH display significant anti-hepatitis C viral effect in vitro and in recombinant HepG2 and CCL13 cells

Journal of hepatology, 2006-06, Vol.44 (6), p.1017-1025

2006

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RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection

Molecular therapy, 2017-09, Vol.25 (9), p.2093-2103

2017

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cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING

Nature (London), 2013-06, Vol.498 (7454), p.380

2013

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Synthesis of α-P-Modified Nucleoside Diphosphates with Ethylenediamine

Journal of the American Chemical Society, 2005-12, Vol.127 (48), p.16782-16783

2005

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Stereospecific synthesis of guanosine 5'-O-(1,2-dithiotriphosphates)

Journal of organic chemistry, 1991-09, Vol.56 (20), p.5860-5865

1991

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Mechanisms of small RNA mediated mammalian gene silencing

The FASEB journal, 2007-04, Vol.21 (5), p.A149-A149

2007

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miRNA in situ hybridization in mammalian tissues fixed with formaldehyde and EDC

Nature methods, 2009-01, Vol.6 (2), p.139-141

2009

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Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing

RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

NUDT2 initiates viral RNA degradation by removal of 5′-phosphates

Ribozyme Assays to Quantify the Capping Efficiency of In Vitro-Transcribed mRNA

RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2′O-Methylated Self RNA

Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self-DNA based on CpG-specific recognition of phosphodiester DNA

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA

Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I

miRNA in situ hybridization in formaldehyde and EDC-fixed tissues

A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA

Differential gene expression profile analysis of RIG-I- versus type I IFN-stimulated primary human nasal epithelial cells and protection from influenza virus replication

Hammerhead ribozymes with cleavage site specificity for NUH and NCH display significant anti-hepatitis C viral effect in vitro and in recombinant HepG2 and CCL13 cells

RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING

Synthesis of α-P-Modified Nucleoside Diphosphates with Ethylenediamine

Stereospecific synthesis of guanosine 5'-O-(1,2-dithiotriphosphates)

Mechanisms of small RNA mediated mammalian gene silencing

miRNA in situ hybridization in mammalian tissues fixed with formaldehyde and EDC

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