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Structural Plasticity in the C‑Terminal Region of Macrophage Migration Inhibitory Factor‑2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor

Biochemistry (Easton), 2018-07, Vol.57 (26), p.3599-3605

2018

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Engineering of the high-affinity chemokine CXCL13 to screen CXCR5 antagonists to treat cancer and autoimmune diseases

Biophysical journal, 2023-02, Vol.122 (3), p.474a-474a

2023

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CD74 is a novel transcription regulator

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (3), p.562-567

2017

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Targeting distinct tautomerase sites of D‐DT and MIF with a single molecule for inhibition of neutrophil lung recruitment

The FASEB journal, 2014-11, Vol.28 (11), p.4961-4971

2014

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Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60

PloS one, 2020-11, Vol.15 (11), p.e0242725-e0242725

2020

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Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel

Cell chemical biology, 2020-06, Vol.27 (6), p.740-750.e5

2020

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Structure, function, and inhibition of chemokines

Annual review of pharmacology and toxicology, 2002, Vol.42 (1), p.469-499

2002

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Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose

Molecular medicine (Cambridge, Mass.), 2024-03, Vol.30 (1), p.43-43

2024

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K⁺ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension

Science (American Association for the Advancement of Science), 2011-02, Vol.331 (6018), p.768-772

2011

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Mapping N- to C-terminal allosteric coupling through disruption of a putative CD74 activation site in D-dopachrome tautomerase

The Journal of biological chemistry, 2023-06, Vol.299 (6), p.104729-104729, Article 104729

2023

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Nanosecond Dynamics Regulate the MIF‐Induced Activity of CD74

Angewandte Chemie (International ed.), 2018-06, Vol.57 (24), p.7116-7119

International ed. in English, 2018

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Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast

Proceedings of the National Academy of Sciences - PNAS, 2010-06, Vol.107 (25), p.11313-11318

2010

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D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF)

Proceedings of the National Academy of Sciences - PNAS, 2011-08, Vol.108 (34), p.E577-E585

2011

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CD44 Is the Signaling Component of the Macrophage Migration Inhibitory Factor-CD74 Receptor Complex

Immunity (Cambridge, Mass.), 2006-10, Vol.25 (4), p.595-606

2006

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The N‐terminal length and side‐chain composition of CXCL13 affect crystallization, structure and functional activity

Acta crystallographica. Section D, Biological crystallography., 2020-10, Vol.76 (10), p.1033-1049

2020

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Allosteric peptide regulators of chemokine receptors CXCR4 and CXCR7

Biochemical pharmacology, 2013-11, Vol.86 (9), p.1263-1271

2013

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A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase

The Journal of biological chemistry, 2021-09, Vol.297 (3), p.101061, Article 101061

2021

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MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations

Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (27), p.10994-10999

2013

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Protein crystallization facilitated by molecularly imprinted polymers

Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (27), p.11081-11086

2011

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Conformational dynamics of Ca2+-dependent responses in the polycystin-2 C-terminal tail

Biochemical journal, 2016-02, Vol.473 (3), p.285-296

2016

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A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice

The Journal of immunology (1950), 2011-01, Vol.186 (1), p.527-538

2011

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Expression, purification and crystallization of the novel Xenopus tropicalis ALDH16B1, a homologue of human ALDH16A1

Chemico-biological interactions, 2019-05, Vol.304, p.168-172

2019

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Structural and Functional Basis of CXCL12 (Stromal Cell-derived Factor-1α) Binding to Heparin

The Journal of biological chemistry, 2007-03, Vol.282 (13), p.10018-10027

2007

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Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant

Cell chemical biology, 2019-05, Vol.26 (5), p.662-673.e7

2019

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Oligomerization of the Polycystin-2 C-terminal Tail and Effects on Its Ca2+-binding Properties

The Journal of biological chemistry, 2015-04, Vol.290 (16), p.10544-10554

2015

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Structural Plasticity in the C‑Terminal Region of Macrophage Migration Inhibitory Factor‑2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor

Engineering of the high-affinity chemokine CXCL13 to screen CXCR5 antagonists to treat cancer and autoimmune diseases

CD74 is a novel transcription regulator

Targeting distinct tautomerase sites of D‐DT and MIF with a single molecule for inhibition of neutrophil lung recruitment

Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60

Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel

Structure, function, and inhibition of chemokines

Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose

K⁺ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension

Mapping N- to C-terminal allosteric coupling through disruption of a putative CD74 activation site in D-dopachrome tautomerase

Nanosecond Dynamics Regulate the MIF‐Induced Activity of CD74

Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast

D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF)

CD44 Is the Signaling Component of the Macrophage Migration Inhibitory Factor-CD74 Receptor Complex

The N‐terminal length and side‐chain composition of CXCL13 affect crystallization, structure and functional activity

Allosteric peptide regulators of chemokine receptors CXCR4 and CXCR7

A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase

MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations

Protein crystallization facilitated by molecularly imprinted polymers

Conformational dynamics of Ca2+-dependent responses in the polycystin-2 C-terminal tail

A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice

Expression, purification and crystallization of the novel Xenopus tropicalis ALDH16B1, a homologue of human ALDH16A1

Structural and Functional Basis of CXCL12 (Stromal Cell-derived Factor-1α) Binding to Heparin

Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant

Oligomerization of the Polycystin-2 C-terminal Tail and Effects on Its Ca2+-binding Properties

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