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SLC6 neurotransmitter transporters: structure, function, and regulation

Pharmacological reviews, 2011-09, Vol.63 (3), p.585

2011

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The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

Nature communications, 2021-08, Vol.12 (1), p.5063-12, Article 5063

2021

Volltextzugriff (PDF)

Substrate-induced conformational dynamics of the dopamine transporter

Nature communications, 2019-06, Vol.10 (1), p.2714-14, Article 2714

2019

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Conformational dynamics of the human serotonin transporter during substrate and drug binding

Nature communications, 2019-04, Vol.10 (1), p.1687-1687, Article 1687

2019

Volltextzugriff (PDF)

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

Nature communications, 2020-03, Vol.11 (1), p.1491-12, Article 1491

2020

Volltextzugriff (PDF)

Exploring the K + binding site and its coupling to transport in the neurotransmitter:sodium symporter LeuT

eLife, 2024-01, Vol.12

2024

Volltextzugriff (PDF)

The binding sites for cocaine and dopamine in the dopamine transporter overlap

Nature neuroscience, 2008-07, Vol.11 (7), p.780-789

2008

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X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

Nature communications, 2020-02, Vol.11 (1), p.1005-14, Article 1005

2020

Volltextzugriff (PDF)

Transition metal ion FRET uncovers K + regulation of a neurotransmitter/sodium symporter

Nature communications, 2016-09, Vol.7 (1), p.12755-12755, Article 12755

2016

Volltextzugriff (PDF)

The dopamine transporter antiports potassium to increase the uptake of dopamine

Nature communications, 2022-05, Vol.13 (1), p.2446-2446, Article 2446

2022

Volltextzugriff (PDF)

A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins

Chemistry : a European journal, 2012-07, Vol.18 (31), p.9485-9490

2012

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Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila

The Plant journal : for cell and molecular biology, 2021-10, Vol.108 (2), p.555-578

2021

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An Intracellular Interaction Network Regulates Conformational Transitions in the Dopamine Transporter

The Journal of biological chemistry, 2008-06, Vol.283 (25), p.17691-17701

2008

Volltextzugriff (PDF)

Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability

Organic & biomolecular chemistry, 2019-03, Vol.17 (12), p.3249-3257

2019

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The Environment Shapes the Inner Vestibule of LeuT

PLoS computational biology, 2016-11, Vol.12 (11), p.e1005197-e1005197

2016

Volltextzugriff (PDF)

Relationship between Conformational Changes in the Dopamine Transporter and Cocaine-Like Subjective Effects of Uptake Inhibitors

Molecular pharmacology, 2008-03, Vol.73 (3), p.813-823

2008

Volltextzugriff (PDF)

The use of LeuT as a model in elucidating binding sites for substrates and inhibitors in neurotransmitter transporters

Biochimica et biophysica acta, 2015-03, Vol.1850 (3), p.500-510

Loland, Claus J.

2015

Volltextzugriff (PDF)

Tandem malonate-based glucosides (TMGs) for membrane protein structural studies

Scientific reports, 2017-06, Vol.7 (1), p.3963-11, Article 3963

2017

Volltextzugriff (PDF)

Transmembrane transporter proteins: Capturing transport in motion

Basic & clinical pharmacology & toxicology, 2024-02, Vol.134 (2), p.203-205

2024

Volltextzugriff (PDF)

Neuropsychiatric disease–associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes

The Journal of biological chemistry, 2018-05, Vol.293 (19), p.7250-7262

2018

Volltextzugriff (PDF)

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

eLife, 2017-01, Vol.6

2017

Volltextzugriff (PDF)

Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution

Neurochemical research, 2022, Vol.47 (1), p.127-137

2022

Volltextzugriff (PDF)

Dynamic extracellular vestibule of human SERT: Unveiling druggable potential with high-affinity allosteric inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2023-10, Vol.120 (41), p.e2304089120-e2304089120

2023

Volltextzugriff (PDF)

Rational Approach to Improve Detergent Efficacy for Membrane Protein Stabilization

Bioconjugate chemistry, 2024-02, Vol.35 (2), p.223-231

2024

Volltextzugriff (PDF)

Regulation of Dopamine Transporter Trafficking by Intracellular Amphetamine

Molecular pharmacology, 2006-08, Vol.70 (2), p.542-548

2006

Volltextzugriff (PDF)

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SLC6 neurotransmitter transporters: structure, function, and regulation

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

Substrate-induced conformational dynamics of the dopamine transporter

Conformational dynamics of the human serotonin transporter during substrate and drug binding

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

Exploring the K + binding site and its coupling to transport in the neurotransmitter:sodium symporter LeuT

The binding sites for cocaine and dopamine in the dopamine transporter overlap

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

Transition metal ion FRET uncovers K + regulation of a neurotransmitter/sodium symporter

The dopamine transporter antiports potassium to increase the uptake of dopamine

A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins

Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila

An Intracellular Interaction Network Regulates Conformational Transitions in the Dopamine Transporter

Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability

The Environment Shapes the Inner Vestibule of LeuT

Relationship between Conformational Changes in the Dopamine Transporter and Cocaine-Like Subjective Effects of Uptake Inhibitors

The use of LeuT as a model in elucidating binding sites for substrates and inhibitors in neurotransmitter transporters

Tandem malonate-based glucosides (TMGs) for membrane protein structural studies

Transmembrane transporter proteins: Capturing transport in motion

Neuropsychiatric disease–associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution

Dynamic extracellular vestibule of human SERT: Unveiling druggable potential with high-affinity allosteric inhibitors

Rational Approach to Improve Detergent Efficacy for Membrane Protein Stabilization

Regulation of Dopamine Transporter Trafficking by Intracellular Amphetamine

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