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Form and function in cyclic peptide natural products: a pharmacokinetic perspective

Current topics in medicinal chemistry, 2013-05, Vol.13 (7), p.821-836

2013

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Retrospective analysis of natural products provides insights for future discovery trends

Proceedings of the National Academy of Sciences - PNAS, 2017-05, Vol.114 (22), p.5601-5606

2017

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Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity

Journal of medicinal chemistry, 2021-12, Vol.64 (24), p.18082-18101

2021

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A New Amino Acid for Improving Permeability and Solubility in Macrocyclic Peptides through Side Chain-to-Backbone Hydrogen Bonding

Journal of medicinal chemistry, 2022-03, Vol.65 (6), p.5072-5084

2022

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Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets

Current opinion in chemical biology, 2017-06, Vol.38, p.141-147

2017

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Conformation and Permeability: Cyclic Hexapeptide Diastereomers

Journal of chemical information and modeling, 2019-06, Vol.59 (6), p.2952-2963

2019

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Drug‐Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side‐Chain Lipophilicity

Angewandte Chemie International Edition, 2020-11, Vol.59 (48), p.21571-21577

International ed. in English, 2020

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Reliance of Wolbachia on High Rates of Host Proteolysis Revealed by a Genome-Wide RNAi Screen of Drosophila Cells

Genetics (Austin), 2017-04, Vol.205 (4), p.1473-1488

2017

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Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility

Journal of medicinal chemistry, 2018-12, Vol.61 (24), p.11169-11182

2018

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Cyclosporin A: Conformational Complexity and Chameleonicity

Journal of chemical information and modeling, 2021-11, Vol.61 (11), p.5601-5613

2021

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Geometrically Diverse Lariat Peptide Scaffolds Reveal an Untapped Chemical Space of High Membrane Permeability

Journal of the American Chemical Society, 2021-01, Vol.143 (2), p.705-714

2021

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Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules

Journal of medicinal chemistry, 2017-03, Vol.60 (5), p.1665-1672

2017

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Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry

Journal of medicinal chemistry, 2016-10, Vol.59 (20), p.9503-9512

2016

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Developing Cyclic Peptomers as Broad-Spectrum Type III Secretion System Inhibitors in Gram-Negative Bacteria

Antimicrobial agents and chemotherapy, 2021-06, Vol.65 (7), p.e0169020

2021

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Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides

Nature communications, 2023-03, Vol.14 (1), p.1416-14, Article 1416

2023

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On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

Nature chemical biology, 2011-09, Vol.7 (11), p.810-817

2011

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Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products

Journal of medicinal chemistry, 2015-06, Vol.58 (11), p.4581-4589

2015

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Testing the Conformational Hypothesis of Passive Membrane Permeability Using Synthetic Cyclic Peptide Diastereomers

Journal of the American Chemical Society, 2006-03, Vol.128 (8), p.2510-2511

2006

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Genome‐Based Identification of a Plant‐Associated Marine Bacterium as a Rich Natural Product Source

Angewandte Chemie International Edition, 2018-10, Vol.57 (44), p.14519-14523

International ed. in English, 2018

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Beyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products

Future medicinal chemistry, 2015-01, Vol.7 (16), p.2121-2130

2015

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Click Chemistry as a Macrocyclization Tool in the Solid-Phase Synthesis of Small Cyclic Peptides

Organic letters, 2007-11, Vol.9 (24), p.5011-5014

2007

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Conformational Flexibility, Internal Hydrogen Bonding, and Passive Membrane Permeability: Successful in Silico Prediction of the Relative Permeabilities of Cyclic Peptides

Journal of the American Chemical Society, 2006-11, Vol.128 (43), p.14073-14080

2006

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Discovery of Potent and Orally Bioavailable Macrocyclic Peptide–Peptoid Hybrid CXCR7 Modulators

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9653-9663

2017

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An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

PloS one, 2020-05, Vol.15 (5), p.e0233672-e0233672

2020

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Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides

Organic letters, 2015-06, Vol.17 (12), p.2928-2931

2015

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Form and function in cyclic peptide natural products: a pharmacokinetic perspective

Retrospective analysis of natural products provides insights for future discovery trends

Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity

A New Amino Acid for Improving Permeability and Solubility in Macrocyclic Peptides through Side Chain-to-Backbone Hydrogen Bonding

Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets

Conformation and Permeability: Cyclic Hexapeptide Diastereomers

Drug‐Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side‐Chain Lipophilicity

Reliance of Wolbachia on High Rates of Host Proteolysis Revealed by a Genome-Wide RNAi Screen of Drosophila Cells

Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility

Cyclosporin A: Conformational Complexity and Chameleonicity

Geometrically Diverse Lariat Peptide Scaffolds Reveal an Untapped Chemical Space of High Membrane Permeability

Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules

Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry

Developing Cyclic Peptomers as Broad-Spectrum Type III Secretion System Inhibitors in Gram-Negative Bacteria

Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products

Testing the Conformational Hypothesis of Passive Membrane Permeability Using Synthetic Cyclic Peptide Diastereomers

Genome‐Based Identification of a Plant‐Associated Marine Bacterium as a Rich Natural Product Source

Beyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products

Click Chemistry as a Macrocyclization Tool in the Solid-Phase Synthesis of Small Cyclic Peptides

Conformational Flexibility, Internal Hydrogen Bonding, and Passive Membrane Permeability: Successful in Silico Prediction of the Relative Permeabilities of Cyclic Peptides

Discovery of Potent and Orally Bioavailable Macrocyclic Peptide–Peptoid Hybrid CXCR7 Modulators

An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides

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