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PKC regulation of ion channels: The involvement of PIP2

The Journal of biological chemistry, 2022-06, Vol.298 (6), p.102035-102035, Article 102035

2022

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PIP2 regulation of TRPC5 channel activation and desensitization

The Journal of biological chemistry, 2021-01, Vol.296, p.100726-100726, Article 100726

2021

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Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

Cell, 2011-11, Vol.147 (5), p.1011-1023

2011

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PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain

Nature neuroscience, 2005-05, Vol.8 (5), p.626-634

2005

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The Molecular Mechanism by which PIP2 Opens the Intracellular G-Loop Gate of a Kir3.1 Channel

Biophysical journal, 2012-05, Vol.102 (9), p.2049-2059

2012

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Epilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different Mechanisms

Cell reports (Cambridge), 2016-01, Vol.14 (1), p.129-139

2016

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Phosphoinositide Control of Membrane Protein Function: A Frontier Led by Studies on Ion Channels

Annual review of physiology, 2015-01, Vol.77 (1), p.81-104

2015

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Use of a Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism

International journal of molecular sciences, 2022-09, Vol.23 (18), p.10820

2022

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Activation of specific bitter taste receptors by olive oil phenolics and secoiridoids

Scientific reports, 2021-11, Vol.11 (1), p.22340-22340, Article 22340

2021

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Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex

Nature chemical biology, 2014-09, Vol.10 (9), p.753-759

2014

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Cholesterol Sensitivity of KIR2.1 Is Controlled by a Belt of Residues around the Cytosolic Pore

Biophysical journal, 2011-01, Vol.100 (2), p.381-389

2011

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A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state

Nature communications, 2024-08, Vol.15 (1), p.6643-18, Article 6643

2024

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PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4–S5 linker

Proceedings of the National Academy of Sciences - PNAS, 2012-09, Vol.109 (36), p.E2399-E2408

2012

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Molecular annotation of G protein variants in a neurological disorder

Cell reports (Cambridge), 2023-12, Vol.42 (12), p.113462-113462, Article 113462

2023

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The Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel

Scientific reports, 2016-07, Vol.6 (1), p.29399-29399, Article 29399

2016

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A Critical Gating Switch at a Modulatory Site in Neuronal Kir3 Channels

The Journal of neuroscience, 2015-10, Vol.35 (42), p.14397-14405

2015

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Structural Determinants of Phosphatidylinositol 4,5-Bisphosphate (PIP2) Regulation of BK Channel Activity through the RCK1 Ca2+ Coordination Site

The Journal of biological chemistry, 2014-07, Vol.289 (27), p.18860-18872

2014

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Molecular annotation of G protein variants in a neurological disorder

Cell reports (Cambridge), 2023-12, Vol.42 (12), p.113578-113578, Article 113578

2023

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Phosphoinositide-mediated gating of inwardly rectifying K(+) channels

Pflügers Archiv, 2007-10, Vol.455 (1), p.83-95

2007

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PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels

The Journal of physiology, 2005-04, Vol.564 (1), p.117-129

2005

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Correction: Elucidation of molecular kinetic schemes from macroscopic traces using system identification

PLoS computational biology, 2018-10, Vol.14 (10), p.e1006539-e1006539

2018

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Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

Neuron (Cambridge, Mass.), 2002-06, Vol.34 (6), p.933-944

2002

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The RCK2 domain uses a coordination site present in Kir channels to confer sodium sensitivity to Slo2.2 channels

The Journal of neuroscience, 2010-06, Vol.30 (22), p.7554-7562

2010

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Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol

Proceedings of the National Academy of Sciences - PNAS, 2009-05, Vol.106 (19), p.8055-8060

2009

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PKC regulation of ion channels: The involvement of PIP2

PIP2 regulation of TRPC5 channel activation and desensitization

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain

The Molecular Mechanism by which PIP2 Opens the Intracellular G-Loop Gate of a Kir3.1 Channel

Epilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different Mechanisms

Phosphoinositide Control of Membrane Protein Function: A Frontier Led by Studies on Ion Channels

Use of a Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism

Activation of specific bitter taste receptors by olive oil phenolics and secoiridoids

Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex

Cholesterol Sensitivity of KIR2.1 Is Controlled by a Belt of Residues around the Cytosolic Pore

A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state

PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4–S5 linker

Molecular annotation of G protein variants in a neurological disorder

Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl Cyclase

The Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel

A Critical Gating Switch at a Modulatory Site in Neuronal Kir3 Channels

Structural Determinants of Phosphatidylinositol 4,5-Bisphosphate (PIP2) Regulation of BK Channel Activity through the RCK1 Ca2+ Coordination Site

Molecular annotation of G protein variants in a neurological disorder

Phosphoinositide-mediated gating of inwardly rectifying K(+) channels

PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels

Correction: Elucidation of molecular kinetic schemes from macroscopic traces using system identification

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

The RCK2 domain uses a coordination site present in Kir channels to confer sodium sensitivity to Slo2.2 channels

Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol

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