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Clinically Relevant Concentrations of Anticancer Drugs: A Guide for Nonclinical Studies

Clinical cancer research, 2017-07, Vol.23 (14), p.3489-3498

2017

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Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease

European journal of pharmacology, 2004-02, Vol.486 (1), p.9-17

2004

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Design and Synthesis of 1-Heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one Derivatives as Potent, Selective Acetylcholinesterase Inhibitors

Journal of medicinal chemistry, 1995-03, Vol.38 (7), p.1084-1089

1995

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Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase

Bioorganic & medicinal chemistry letters, 2004-09, Vol.14 (17), p.4511-4514

2004

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Killing pain, not neurons

Nature medicine, 2005-08, Vol.11 (8), p.817-818

2005

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Novel Benzisoxazole Derivatives as Potent and Selective Inhibitors of Acetylcholinesterase

Journal of medicinal chemistry, 1994-08, Vol.37 (17), p.2721-2734

1994

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Presence in brain of synenkephalin, a proenkephalin-immunoreactive protein which does not contain enkephalin

Nature (London), 1983-03, Vol.302 (5903), p.62-65

1983

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5,7-Dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: A Potent and Centrally-Selective Inhibitor of Acetylcholinesterase

Journal of medicinal chemistry, 1995-07, Vol.38 (15), p.2802-2808

1995

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Clozapine is a potent and selective muscarinic M4 receptor agonist

European journal of pharmacology. Molecular pharmacology section, 1994-11, Vol.269 (3), p.R1-R2

1994

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5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety

Journal of medicinal chemistry, 1995-07, Vol.38 (15), p.2802

1995

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Physical parameters for brian uptake: optimizing log P, log D and pKa of T H A

Bioorganic & medicinal chemistry letters, 1991-01, Vol.1 (8), p.411-414

1991

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Methyl-β-carboline-induced convulsions are antagonized by Ro 15-1788 and by propyl-β-carboline

European journal of pharmacology, 1982-11, Vol.85 (1), p.93-97

1982

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Physical parameters for brian uptake: optimizing log P, log D and pK a of T H A

Bioorganic & medicinal chemistry letters, 1991, Vol.1 (8), p.411-414

1991

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Substituted 6-Phenyl-pyridin-2-ylamines: Selective and Potent Inhibitors of Neuronal Nitric Oxide Synthase

ChemInform, 2004-12, Vol.35 (52), p.no-no

2004

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Biochemical Evidence for Alteration of Neostriatal Dopaminergic Function by 5,7‐Dihydroxytryptamine

Journal of neurochemistry, 1982-05, Vol.38 (5), p.1329-1335

1982

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Clozapine is a potent and selective muscarinic M 4 receptor agonist

European journal of pharmacology. Molecular pharmacology section, 1994, Vol.269 (3), p.R1-R2

1994

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Fetal, Infant and Maternal Outcomes among Women with Prolapsed Membranes Admitted before 29 Weeks Gestation

PloS one, 2016-12, Vol.11 (12), p.e0168285-e0168285

2016

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Nucleotide P2Y1 receptor agonists are in vitro and in vivo prodrugs of A1/A3 adenosine receptor agonists: implications for roles of P2Y1 and A1/A3 receptors in physiology and pathology

Purinergic signalling, 2020-12, Vol.16 (4), p.543-559

2020

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Magnesium Sulphate for Eclampsia and Fetal Neuroprotection: A Comparative Analysis of Protocols Across Canadian Tertiary Perinatal Centres

Journal of obstetrics and gynaecology Canada, 2015-11, Vol.37 (11), p.975-987

2015

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Magnesium sulphate for fetal neuroprotection: benefits and challenges of a systematic knowledge translation project in Canada

BMC pregnancy and childbirth, 2015-12, Vol.15 (1), p.347-347, Article 347

2015

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Effect of Magnesium Sulphate on Fetal Heart Rate Parameters: A Systematic Review

Journal of obstetrics and gynaecology Canada, 2014-12, Vol.36 (12), p.1055-1064

2014

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Nucleotide P2Y 1 receptor agonists are in vitro and in vivo prodrugs of A 1 /A 3 adenosine receptor agonists: implications for roles of P2Y 1 and A 1 /A 3 receptors in physiology and pathology

Purinergic signalling, 2020-12, Vol.16 (4), p.543

2020

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Structure−Activity Relationships of Potent, Selective Inhibitors of Neuronal Nitric Oxide Synthase Based on the 6-Phenyl-2-aminopyridine Structure

Journal of medicinal chemistry, 2004-03, Vol.47 (6), p.1575-1586

2004

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β-secretase inhibitors for treatment of Alzheimer's disease

Alzheimer's & dementia, 2010-07, Vol.6 (4), p.S534-S534

2010

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P3‐282: β‐secretase inhibitors for treatment of Alzheimer's disease

Alzheimer's & dementia, 2010-07, Vol.6 (4S_Part_17), p.S534-S534

2010

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Clinically Relevant Concentrations of Anticancer Drugs: A Guide for Nonclinical Studies

Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease

Design and Synthesis of 1-Heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one Derivatives as Potent, Selective Acetylcholinesterase Inhibitors

Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase

Killing pain, not neurons

Novel Benzisoxazole Derivatives as Potent and Selective Inhibitors of Acetylcholinesterase

Presence in brain of synenkephalin, a proenkephalin-immunoreactive protein which does not contain enkephalin

5,7-Dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: A Potent and Centrally-Selective Inhibitor of Acetylcholinesterase

Clozapine is a potent and selective muscarinic M4 receptor agonist

5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety

Physical parameters for brian uptake: optimizing log P, log D and pKa of T H A

Methyl-β-carboline-induced convulsions are antagonized by Ro 15-1788 and by propyl-β-carboline

Physical parameters for brian uptake: optimizing log P, log D and pK a of T H A

Substituted 6-Phenyl-pyridin-2-ylamines: Selective and Potent Inhibitors of Neuronal Nitric Oxide Synthase

Biochemical Evidence for Alteration of Neostriatal Dopaminergic Function by 5,7‐Dihydroxytryptamine

Clozapine is a potent and selective muscarinic M 4 receptor agonist

Fetal, Infant and Maternal Outcomes among Women with Prolapsed Membranes Admitted before 29 Weeks Gestation

Nucleotide P2Y1 receptor agonists are in vitro and in vivo prodrugs of A1/A3 adenosine receptor agonists: implications for roles of P2Y1 and A1/A3 receptors in physiology and pathology

Magnesium Sulphate for Eclampsia and Fetal Neuroprotection: A Comparative Analysis of Protocols Across Canadian Tertiary Perinatal Centres

Magnesium sulphate for fetal neuroprotection: benefits and challenges of a systematic knowledge translation project in Canada

Effect of Magnesium Sulphate on Fetal Heart Rate Parameters: A Systematic Review

Nucleotide P2Y 1 receptor agonists are in vitro and in vivo prodrugs of A 1 /A 3 adenosine receptor agonists: implications for roles of P2Y 1 and A 1 /A 3 receptors in physiology and pathology

Structure−Activity Relationships of Potent, Selective Inhibitors of Neuronal Nitric Oxide Synthase Based on the 6-Phenyl-2-aminopyridine Structure

β-secretase inhibitors for treatment of Alzheimer's disease

P3‐282: β‐secretase inhibitors for treatment of Alzheimer's disease

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