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Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies

Journal of medicinal chemistry, 2019-04, Vol.62 (8), p.3898-3923

2019

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VEGF signal system: the application of antiangiogenesis

Current medicinal chemistry, 2014-03, Vol.21 (7), p.894

2014

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Design, synthesis and anti-tumor activity study of novel histone deacetylase inhibitors containing isatin-based caps and o-phenylenediamine-based zinc binding groups

Bioorganic & medicinal chemistry, 2017-06, Vol.25 (12), p.2981-2994

2017

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The Effects of Composite Alkali-Stored Spent Hypsizygus marmoreus Substrate on Carcass Quality, Rumen Fermentation, and Rumen Microbial Diversity in Goats

Animals (Basel), 2024-01, Vol.14 (1), p.166

2024

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Genome-wide association studies for the concentrations of insulin, triiodothyronine, and thyroxine in Chinese Holstein cattle

Tropical animal health and production, 2020-07, Vol.52 (4), p.1655-1660

2020

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Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors

Acta pharmaceutica Sinica. B, 2023-12, Vol.13 (12), p.4918-4933

2023

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Discovery of Novel Pazopanib-Based HDAC and VEGFR Dual Inhibitors Targeting Cancer Epigenetics and Angiogenesis Simultaneously

Journal of medicinal chemistry, 2018-06, Vol.61 (12), p.5304-5322

2018

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The new direction of drug development: Degradation of undruggable targets through targeting chimera technology

Medicinal research reviews, 2024-03, Vol.44 (2), p.632-685

2024

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Discovery of Novel Pyrrolo[2,3‑d]pyrimidine-based Derivatives as Potent JAK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors

Journal of medicinal chemistry, 2022-01, Vol.65 (2), p.1243-1264

2022

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Construction of Diversified Penta-spiro-heterocyclic and Fused-heterocyclic Frameworks with Potent Antitumor Activity

Chemistry : a European journal, 2023-09, Vol.29 (54), p.e202301553-e202301553

2023

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Construction of Diversified Penta‐Spiro‐Heterocyclic and Fused‐Heterocyclic Frameworks with Potent Antitumor Activity

Chemistry : a European journal, 2023-09, Vol.29 (54), p.e202302677-e202302677

2023

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Front Cover: Construction of Diversified Penta‐Spiro‐Heterocyclic and Fused‐Heterocyclic Frameworks with Potent Antitumor Activity (Chem. Eur. J. 54/2023)

Chemistry : a European journal, 2023-09, Vol.29 (54)

2023

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Novel-targeted therapy for hematological malignancies with JAK and HDAC dual inhibitors

Future medicinal chemistry, 2019-08, Vol.11 (16), p.1849-1852

2019

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I2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines

Green chemistry : an international journal and green chemistry resource : GC, 2021-11, Vol.23 (22), p.9165-9171

2021

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I 2 -induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines

Green chemistry : an international journal and green chemistry resource : GC, 2021-11, Vol.23 (22), p.9165-9171

2021

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Development of Potent MALT1 Inhibitors Featuring a Novel “2-Thioxo-2,3-dihydrothiazolo[4,5‑d]pyrimidin-7(6H)‑one” Scaffold for the Treatment of B Cell Lymphoma

Journal of medicinal chemistry, 2024-02, Vol.67 (4), p.2884-2906

2024

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I-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines

Green chemistry : an international journal and green chemistry resource : GC, 2021-11, Vol.23 (22), p.9165-9171

2021

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Discovery of Novel Imidazo[4,5‑c]quinoline Derivatives to Treat Inflammatory Bowel Disease (IBD) by Inhibiting Multiple Proinflammatory Signaling Pathways and Restoring Intestinal Homeostasis

Journal of medicinal chemistry, 2022-09, Vol.65 (18), p.11949-11969

2022

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Inside Front Cover Image, Volume 41, Issue 4

Medicinal research reviews, 2021-07, Vol.41 (4), p.ii-ii

2021

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Discovery of Novel Pyrimidine-Based Derivatives as Nav1.2 Inhibitors with Efficacy in Mouse Models of Epilepsy

Journal of medicinal chemistry, 2024-07

2024

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Development of N-hydroxycinnamamide-based HDAC inhibitors with improved HDAC inhibitory activity and in vitro antitumor activity

Bioorganic & medicinal chemistry, 2017-05, Vol.25 (9), p.2666-2675

2017

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Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease

Journal of medicinal chemistry, 2024-04, Vol.67 (7), p.5642-5661

2024

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Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma

Journal of medicinal chemistry, 2021-07, Vol.64 (13), p.9217-9237

2021

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Identification and experimental validation of PYCARD as a crucial PANoptosis-related gene for immune response and inflammation in COPD

Apoptosis (London), 2024-04

2024

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Optimization of N‑Substituted Oseltamivir Derivatives as Potent Inhibitors of Group‑1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant

Journal of medicinal chemistry, 2018-07, Vol.61 (14), p.6379-6397

2018

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Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies

VEGF signal system: the application of antiangiogenesis

Design, synthesis and anti-tumor activity study of novel histone deacetylase inhibitors containing isatin-based caps and o-phenylenediamine-based zinc binding groups

The Effects of Composite Alkali-Stored Spent Hypsizygus marmoreus Substrate on Carcass Quality, Rumen Fermentation, and Rumen Microbial Diversity in Goats

Genome-wide association studies for the concentrations of insulin, triiodothyronine, and thyroxine in Chinese Holstein cattle

Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors

Discovery of Novel Pazopanib-Based HDAC and VEGFR Dual Inhibitors Targeting Cancer Epigenetics and Angiogenesis Simultaneously

The new direction of drug development: Degradation of undruggable targets through targeting chimera technology

Discovery of Novel Pyrrolo[2,3‑d]pyrimidine-based Derivatives as Potent JAK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors

Construction of Diversified Penta-spiro-heterocyclic and Fused-heterocyclic Frameworks with Potent Antitumor Activity

Construction of Diversified Penta‐Spiro‐Heterocyclic and Fused‐Heterocyclic Frameworks with Potent Antitumor Activity

Front Cover: Construction of Diversified Penta‐Spiro‐Heterocyclic and Fused‐Heterocyclic Frameworks with Potent Antitumor Activity (Chem. Eur. J. 54/2023)

Novel-targeted therapy for hematological malignancies with JAK and HDAC dual inhibitors

I2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines

I 2 -induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines

Development of Potent MALT1 Inhibitors Featuring a Novel “2-Thioxo-2,3-dihydrothiazolo[4,5‑d]pyrimidin-7(6H)‑one” Scaffold for the Treatment of B Cell Lymphoma

I-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines

Discovery of Novel Imidazo[4,5‑c]quinoline Derivatives to Treat Inflammatory Bowel Disease (IBD) by Inhibiting Multiple Proinflammatory Signaling Pathways and Restoring Intestinal Homeostasis

Inside Front Cover Image, Volume 41, Issue 4

Discovery of Novel Pyrimidine-Based Derivatives as Nav1.2 Inhibitors with Efficacy in Mouse Models of Epilepsy

Development of N-hydroxycinnamamide-based HDAC inhibitors with improved HDAC inhibitory activity and in vitro antitumor activity

Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease

Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma

Identification and experimental validation of PYCARD as a crucial PANoptosis-related gene for immune response and inflammation in COPD

Optimization of N‑Substituted Oseltamivir Derivatives as Potent Inhibitors of Group‑1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant

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