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Latent TGFβ1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder

The EMBO journal, 2004-04, Vol.23 (8), p.1770-1781

2004

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Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2

Nature Immunology, 2007-05, Vol.8 (5), p.504-513

2007

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Fuz Controls the Morphogenesis and Differentiation of Hair Follicles through the Formation of Primary Cilia

Journal of investigative dermatology, 2011-02, Vol.131 (2), p.302-310

2011

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Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (50), p.20224-20229

2013

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Targeted mRNA Therapy for Ornithine Transcarbamylase Deficiency

Molecular therapy, 2018-03, Vol.26 (3), p.801-813

2018

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Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5‑Chloro‑N2‑(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)‑N4‑(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials

Journal of medicinal chemistry, 2013-07, Vol.56 (14), p.5675-5690

2013

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Overexpression of transforming growth factor β1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation

Cancer research (Chicago, Ill.), 2004-07, Vol.64 (13), p.4405-4410

2004

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Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors

Nature (London), 2010-01, Vol.463 (7280), p.501-506

2010

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Essential roles of BMPR-IA signaling in differentiation and growth of hair follicles and in skin tumorigenesis

Genesis (New York, N.Y. : 2000), 2004-05, Vol.39 (1), p.10-25

2004

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Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma

Genes & development, 2006-05, Vol.20 (10), p.1331-1342

2006

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Signaling mechanism of TGF-β1 in prevention of renal inflammation : Role of Smad7

Journal of the American Society of Nephrology, 2005-05, Vol.16 (5), p.1371-1383

2005

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A Role for TGFβ Signaling in the Pathogenesis of Psoriasis

Journal of investigative dermatology, 2010-02, Vol.130 (2), p.371-377

2010

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Smad7-Induced β-Catenin Degradation Alters Epidermal Appendage Development

Developmental cell, 2006-09, Vol.11 (3), p.301-312

2006

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Smad3 knockout mice exhibit a resistance to skin chemical carcinogenesis

Cancer research (Chicago, Ill.), 2004-11, Vol.64 (21), p.7836-7845

2004

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The Role of Smads in Skin Development

Journal of investigative dermatology, 2008-04, Vol.128 (4), p.783-790

2008

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Elevation of transforming growth factor beta (TGFβ) and its downstream mediators in subcutaneous foreign body capsule tissue

Journal of biomedical materials research. Part A, 2007-08, Vol.82A (2), p.498-508

2007

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Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues

The EMBO journal, 2002-06, Vol.21 (11), p.2580-2590

2002

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Increased expression of Interleukin-13 and connective tissue growth factor, and their potential roles during foreign body encapsulation of subcutaneous implants

Journal of biomaterials science. Polymer ed., 2008-01, Vol.19 (8), p.1065-1072

2008

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Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro- N 2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)- N 4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials

Journal of medicinal chemistry, 2013-07, Vol.56 (14), p.5675-5690

2013

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Distinct mechanisms of TGF-β1–mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis

The Journal of clinical investigation, 2005-07, Vol.115 (7), p.1714-1723

2005

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A Role for TGF[beta] Signaling in the Pathogenesis of Psoriasis

Journal of investigative dermatology, 2010-02, Vol.130 (2), p.371

2010

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Distinct mechanisms of TGF-[beta]^sub 1^-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis

The Journal of clinical investigation, 2005-07, Vol.115 (7), p.1714

2005

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Roles of TGFβ signaling in epidermal/appendage development

Cytokine & growth factor reviews, 2003-04, Vol.14 (2), p.99-111

2003

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Targeting wild-type and T315I Bcr-Abl by combining allosteric with ATP-site inhibitors

Nature (London), 2010-01, Vol.463 (7280), p.501-506

2010

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Distinct mechanisms of TGF-beta1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis

The Journal of clinical investigation, 2005-07, Vol.115 (7), p.1714

2005

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Latent TGFβ1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder

Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2

Fuz Controls the Morphogenesis and Differentiation of Hair Follicles through the Formation of Primary Cilia

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Targeted mRNA Therapy for Ornithine Transcarbamylase Deficiency

Overexpression of transforming growth factor β1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation

Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors

Essential roles of BMPR-IA signaling in differentiation and growth of hair follicles and in skin tumorigenesis

Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma

Signaling mechanism of TGF-β1 in prevention of renal inflammation : Role of Smad7

A Role for TGFβ Signaling in the Pathogenesis of Psoriasis

Smad7-Induced β-Catenin Degradation Alters Epidermal Appendage Development

Smad3 knockout mice exhibit a resistance to skin chemical carcinogenesis

The Role of Smads in Skin Development

Elevation of transforming growth factor beta (TGFβ) and its downstream mediators in subcutaneous foreign body capsule tissue

Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues

Increased expression of Interleukin-13 and connective tissue growth factor, and their potential roles during foreign body encapsulation of subcutaneous implants

Distinct mechanisms of TGF-β1–mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis

A Role for TGF[beta] Signaling in the Pathogenesis of Psoriasis

Distinct mechanisms of TGF-[beta]^sub 1^-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis

Roles of TGFβ signaling in epidermal/appendage development

Targeting wild-type and T315I Bcr-Abl by combining allosteric with ATP-site inhibitors

Distinct mechanisms of TGF-beta1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis

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