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Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease

Neuron (Cambridge, Mass.), 2020-12, Vol.108 (5), p.801-821

2020

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Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD

Neuron (Cambridge, Mass.), 2019-09, Vol.103 (5), p.802-819.e11

2019

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The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons

The Journal of neuroscience, 2017-11, Vol.37 (46), p.11074-11084

2017

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DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (10), p.4039-4044

2013

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Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region

EMBO molecular medicine, 2020-04, Vol.12 (4), p.e11227-n/a

2020

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JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis

The Journal of cell biology, 2013-09, Vol.202 (5), p.747-763

2013

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Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease

Science translational medicine, 2017-08, Vol.9 (403)

2017

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DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity

The Journal of cell biology, 2011-09, Vol.194 (5), p.751-764

2011

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C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (46), p.E4385-E4392

2013

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A Feedback Mechanism Regulates Monoallelic Odorant Receptor Expression

Proceedings of the National Academy of Sciences - PNAS, 2004-01, Vol.101 (4), p.1069-1074

2004

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Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration

The Journal of experimental medicine, 2013-11, Vol.210 (12), p.2553-2567

2013

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Leveraging preclinical models for the development of Alzheimer disease therapeutics

Nature reviews. Drug discovery, 2020-07, Vol.19 (7), p.447-462

2020

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Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes

eLife, 2023-10, Vol.12

2023

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Cell Death and Neurodegeneration

Cold Spring Harbor perspectives in biology, 2020-02, Vol.12 (2), p.a036434

2020

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Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

eLife, 2017-04, Vol.6

2017

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FGF as a Target-Derived Chemoattractant for Developing Motor Axons Genetically Programmed by the LIM Code

Neuron (Cambridge, Mass.), 2006-06, Vol.50 (6), p.841-853

2006

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Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration: Miniperspective

Journal of medicinal chemistry, 2018-09, Vol.61 (18), p.8078-8087

2018

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Cleaning crew: Soluble TREM2 mops up complement

Immunity (Cambridge, Mass.), 2023-08, Vol.56 (8), p.1701-1703

2023

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TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

Neuron (Cambridge, Mass.), 2020-03, Vol.105 (5), p.837-854.e9

2020

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Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

Nature neuroscience, 2020-08, Vol.23 (8), p.927-938

2020

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Biomarker Qualification for Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: Theory and Practice

Annals of neurology, 2024-02, Vol.95 (2), p.211-216

2024

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Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6

PloS one, 2012-12, Vol.7 (12), p.e50864-e50864

2012

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Cholinergic Input Is Required during Embryonic Development to Mediate Proper Assembly of Spinal Locomotor Circuits

Neuron (Cambridge, Mass.), 2005-04, Vol.46 (1), p.37-49

2005

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Spatially coordinated kinase signaling regulates local axon degeneration

The Journal of neuroscience, 2012-09, Vol.32 (39), p.13439-13453

2012

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Alzheimer's Targeted Treatments: Focus on Amyloid and Inflammation

The Journal of neuroscience, 2023-11, Vol.43 (47), p.7894-7898

2023

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Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease

Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD

The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region

JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis

Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity

C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice

A Feedback Mechanism Regulates Monoallelic Odorant Receptor Expression

Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration

Leveraging preclinical models for the development of Alzheimer disease therapeutics

Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes

Cell Death and Neurodegeneration

Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

FGF as a Target-Derived Chemoattractant for Developing Motor Axons Genetically Programmed by the LIM Code

Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration: Miniperspective

Cleaning crew: Soluble TREM2 mops up complement

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

Biomarker Qualification for Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: Theory and Practice

Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6

Cholinergic Input Is Required during Embryonic Development to Mediate Proper Assembly of Spinal Locomotor Circuits

Spatially coordinated kinase signaling regulates local axon degeneration

Alzheimer's Targeted Treatments: Focus on Amyloid and Inflammation

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