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Discovery of (5S,6S,9R)‑5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro‑5H‑cyclohepta[b]pyridin-9-yl 4‑(2-oxo-2,3-dihydro‑1H‑imidazo[4,5‑b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): An Oral Calcitonin Gene-Related Peptide (CGRP) Antagonist in Clinical Trials for Treating Migraine

Journal of medicinal chemistry, 2012-12, Vol.55 (23), p.10644-10651

2012

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Current Methods for Predicting Human Food Effect

The AAPS journal, 2008-06, Vol.10 (2), p.282-288

Lentz, Kimberley A.

2008

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Synthesis and evaluation of carbamate and aryl ether substituted pyrazinones as corticotropin releasing factor-1 (CRF1) receptor antagonists

Bioorganic & medicinal chemistry letters, 2016-05, Vol.26 (9), p.2184-2187

2016

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Phenacetin pharmacokinetics in CYP1A2-deficient beagle dogs

Drug metabolism and disposition, 2012-02, Vol.40 (2), p.228

2012

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An amide-based sulfenamide prodrug of gamma secretase inhibitor BMS–708163 delivers parent drug from an oral conventional solid dosage form in male beagle dog

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (3), p.126856, Article 126856

2020

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The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

The Journal of pharmacology and experimental therapeutics, 2016-07, Vol.358 (1), p.138

2016

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Pharmacodynamics of selective inhibition of γ-secretase by avagacestat

The Journal of pharmacology and experimental therapeutics, 2013-03, Vol.344 (3), p.686

2013

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Acyl Guanidine Inhibitors of β‑Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9208-9223

2012

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Design and optimization of tricyclic gamma-secretase modulators

Bioorganic & medicinal chemistry letters, 2016-03, Vol.26 (5), p.1498-1502

2016

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Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

ACS medicinal chemistry letters, 2010-06, Vol.1 (3), p.120-124

2010

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Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ‑Secretase Modulator BMS-932481

ACS medicinal chemistry letters, 2019-03, Vol.10 (3), p.312-317

2019

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Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (22), p.5040-5047

2015

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Aqueous and cosolvent solubility data for drug-like organic compounds

The AAPS journal, 2005-03, Vol.7 (1), p.E78-E105

2005

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Increased Acyclovir Oral Bioavailability via a Bile Acid Conjugate

Molecular pharmaceutics, 2004-01, Vol.1 (1), p.40-48

2004

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Aqueous and cosolvent solubility data for drug-like organic compounds

The AAPS journal, 2005-04, Vol.7 (1), p.E78-105

2005

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Development and Validation of a Preclinical Food Effect Model

Journal of pharmaceutical sciences, 2007-02, Vol.96 (2), p.459-472

2007

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Design and Characterization of a Novel Fluorinated Magnetic Resonance Imaging Agent for Functional Analysis of Bile Acid Transporter Activity

Pharmaceutical research, 2013-05, Vol.30 (5), p.1240-1251

2013

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BMS-933043, a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia

ACS medicinal chemistry letters, 2017-03, Vol.8 (3), p.366-371

2017

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Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine

ACS medicinal chemistry letters, 2012-04, Vol.3 (4), p.337-341

2012

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P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice

The Journal of pharmacology and experimental therapeutics, 2008-08, Vol.326 (2), p.502

2008

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Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.537-541

2011

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Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE)

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (22), p.6916-6924

2011

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Current Methods for Predicting Human Food Effect

Synthesis and evaluation of carbamate and aryl ether substituted pyrazinones as corticotropin releasing factor-1 (CRF1) receptor antagonists

A Strategy to Minimize Reactive Metabolite Formation: Discovery of (S)-4-(1-Cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a Potent, Orally Bioavailable Corticotropin-Releasing Factor-1 Receptor Antagonist

Phenacetin pharmacokinetics in CYP1A2-deficient beagle dogs

MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity

Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure

An amide-based sulfenamide prodrug of gamma secretase inhibitor BMS–708163 delivers parent drug from an oral conventional solid dosage form in male beagle dog

The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

Pharmacodynamics of selective inhibition of γ-secretase by avagacestat

Acyl Guanidine Inhibitors of β‑Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis

Design and optimization of tricyclic gamma-secretase modulators

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ‑Secretase Modulator BMS-932481

Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)

Aqueous and cosolvent solubility data for drug-like organic compounds

Increased Acyclovir Oral Bioavailability via a Bile Acid Conjugate

Aqueous and cosolvent solubility data for drug-like organic compounds

Development and Validation of a Preclinical Food Effect Model

Design and Characterization of a Novel Fluorinated Magnetic Resonance Imaging Agent for Functional Analysis of Bile Acid Transporter Activity

BMS-933043, a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia

Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine

P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice

Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1

Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE)

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