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RAR and RXR modulation in cancer and metabolic disease

Nature reviews. Drug discovery, 2007-10, Vol.6 (10), p.793-810

2007

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Reduction of Atherosclerosis in Apolipoprotein E Knockout Mice by Activation of the Retinoid X Receptor

Proceedings of the National Academy of Sciences - PNAS, 2001-02, Vol.98 (5), p.2610-2615

2001

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Effects of Rexinoids on Glucose Transport and Insulin-mediated Signaling in Skeletal Muscles of Diabetic (db/db) Mice

The Journal of biological chemistry, 2004-05, Vol.279 (19), p.19721-19731

2004

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Mechanism of Selective Retinoid X Receptor Agonist-Induced Hypothyroidism in the Rat

Endocrinology (Philadelphia), 2002-08, Vol.143 (8), p.2880-2885

2002

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Activation of the Retinoid X Receptor Suppresses Appetite in the Rat

Endocrinology (Philadelphia), 2004-02, Vol.145 (2), p.565-573

2004

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Design, Synthesis, and Structure−Activity Relationship Studies of Novel 6,7-Locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids

Journal of medicinal chemistry, 2003-09, Vol.46 (19), p.4087-4103

2003

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Design, synthesis and structure–activity relationship of novel RXR-selective modulators

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (6), p.1593-1598

2004

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Rosiglitazone induction of Insig-1 in white adipose tissue reveals a novel interplay of peroxisome proliferator-activated receptor gamma and sterol regulatory element-binding protein in the regulation of adipogenesis

The Journal of biological chemistry, 2004-06, Vol.279 (23), p.23908-23915

2004

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LGD-5552, an Antiinflammatory Glucocorticoid Receptor Ligand with Reduced Side Effects, in Vivo

Endocrinology (Philadelphia), 2008-05, Vol.149 (5), p.2080-2089

2008

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Molecular Cloning, Expression and Characterization of Human Peroxisome Proliferator Activated Receptors γ1 and γ2

Biochemical and biophysical research communications, 1996-07, Vol.224 (2), p.431-437

1996

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Differential Effects of Rexinoids and Thiazolidinediones on Metabolic Gene Expression in Diabetic Rodents

Molecular pharmacology, 2001-04, Vol.59 (4), p.765-773

2001

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Pharmacological Manipulation of the RAR/RXR Signaling Pathway Maintains the Repopulating Capacity of Hematopoietic Stem Cells in Culture

Molecular endocrinology (Baltimore, Md.), 2009-02, Vol.23 (2), p.188-201

2009

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Metabolic Effects of Rexinoids: Tissue-Specific Regulation of Lipoprotein Lipase Activity

Molecular pharmacology, 2001-02, Vol.59 (2), p.170-176

2001

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Down-regulation of the Expression of the Obese Gene by an Antidiabetic Thiazolidinedione in Zucker Diabetic Fatty Rats and db/db Mice (∗)

The Journal of biological chemistry, 1996-04, Vol.271 (16), p.9455-9459

1996

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Design and synthesis of novel RXR-selective modulators with improved pharmacological profile

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.4071-4075

2003

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Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies

The Journal of experimental medicine, 2001-04, Vol.193 (7), p.827-838

2001

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Activation of PPARδ alters lipid metabolism in db/db mice

FEBS letters, 2000-05, Vol.473 (3), p.333-336

2000

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A PPARγ mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus

Molecular and cellular endocrinology, 2000-04, Vol.162 (1), p.57-67

2000

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Novel Peroxisome Proliferator-activated Receptor (PPAR) γ and PPARδ Ligands Produce Distinct Biological Effects

The Journal of biological chemistry, 1999-03, Vol.274 (10), p.6718-6725

1999

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Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice

Endocrinology (Philadelphia), 1996-10, Vol.137 (10), p.4189-4195

1996

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A novel insulin secretagogue is a phosphodiesterase inhibitor

Diabetes (New York, N.Y.), 1995-01, Vol.44 (1), p.67-74

1995

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A high-conductance anion channel in adult amphibian skeletal muscle

Pflügers Archiv, 1987-12, Vol.410 (6), p.632-640

1987

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Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat

Endocrinology (Philadelphia), 2002-08, Vol.143 (8), p.2880

2002

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Dose Proportionality and the Effects of Food on Bioavailability of an Immediate-Release Oxycodone Hydrochloride Tablet Designed to Discourage Tampering and Its Relative Bioavailability Compared With a Marketed Oxycodone Tablet Under Fed Conditions: A Single-Dose, Randomized, Open-Label, 5-Way Crossover Study in Healthy Volunteers

Clinical therapeutics, 2012-07, Vol.34 (7), p.1601-1612

2012

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RAR and RXR modulation in cancer and metabolic disease

Reduction of Atherosclerosis in Apolipoprotein E Knockout Mice by Activation of the Retinoid X Receptor

Effects of Rexinoids on Glucose Transport and Insulin-mediated Signaling in Skeletal Muscles of Diabetic (db/db) Mice

Mechanism of Selective Retinoid X Receptor Agonist-Induced Hypothyroidism in the Rat

Activation of the Retinoid X Receptor Suppresses Appetite in the Rat

Design, Synthesis, and Structure−Activity Relationship Studies of Novel 6,7-Locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids

Design, synthesis and structure–activity relationship of novel RXR-selective modulators

Rosiglitazone induction of Insig-1 in white adipose tissue reveals a novel interplay of peroxisome proliferator-activated receptor gamma and sterol regulatory element-binding protein in the regulation of adipogenesis

LGD-5552, an Antiinflammatory Glucocorticoid Receptor Ligand with Reduced Side Effects, in Vivo

Molecular Cloning, Expression and Characterization of Human Peroxisome Proliferator Activated Receptors γ1 and γ2

Biological Characterization of a Heterodimer-Selective Retinoid X Receptor Modulator: Potential Benefits for the Treatment of Type 2 Diabetes

Differential Effects of Rexinoids and Thiazolidinediones on Metabolic Gene Expression in Diabetic Rodents

Pharmacological Manipulation of the RAR/RXR Signaling Pathway Maintains the Repopulating Capacity of Hematopoietic Stem Cells in Culture

Metabolic Effects of Rexinoids: Tissue-Specific Regulation of Lipoprotein Lipase Activity

Down-regulation of the Expression of the Obese Gene by an Antidiabetic Thiazolidinedione in Zucker Diabetic Fatty Rats and db/db Mice (∗)

Design and synthesis of novel RXR-selective modulators with improved pharmacological profile

Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies

Activation of PPARδ alters lipid metabolism in db/db mice

A PPARγ mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus

Novel Peroxisome Proliferator-activated Receptor (PPAR) γ and PPARδ Ligands Produce Distinct Biological Effects

Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice

A novel insulin secretagogue is a phosphodiesterase inhibitor

A high-conductance anion channel in adult amphibian skeletal muscle

Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat

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