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Molecular inflation, attrition and the rule of five

Advanced drug delivery reviews, 2016-06, Vol.101, p.22-33

Leeson, Paul D.

2016

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The influence of drug-like concepts on decision-making in medicinal chemistry

Nature reviews. Drug discovery, 2007-11, Vol.6 (11), p.881-890

2007

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Impact of Physicochemical Properties on Dose and Hepatotoxicity of Oral Drugs

Chemical research in toxicology, 2018-06, Vol.31 (6), p.494-505

Leeson, Paul D

2018

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Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations

Journal of medicinal chemistry, 2018-08, Vol.61 (15), p.6421-6467

2018

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An analysis of the attrition of drug candidates from four major pharmaceutical companies

Nature reviews. Drug discovery, 2015-07, Vol.14 (7), p.475-486

2015

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The role of ligand efficiency metrics in drug discovery

Nature reviews. Drug discovery, 2014-02, Vol.13 (2), p.105-121

2014

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The influence of the 'organizational factor' on compound quality in drug discovery

Nature reviews. Drug discovery, 2011-10, Vol.10 (10), p.749-765

2011

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A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs

Journal of medicinal chemistry, 2003-03, Vol.46 (7), p.1250-1256

2003

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From ATP to AZD6140 : The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis

Bioorganic & medicinal chemistry letters, 2007-11, Vol.17 (21), p.6013-6018

2007

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Target-Based Evaluation of “Drug-Like” Properties and Ligand Efficiencies

Journal of medicinal chemistry, 2021-06, Vol.64 (11), p.7210-7230

2021

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Molecular Property Design: Does Everyone Get It?

ACS medicinal chemistry letters, 2015-07, Vol.6 (7), p.722-725

2015

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Occurrence of “Natural Selection” in Successful Small Molecule Drug Discovery

Journal of medicinal chemistry, 2024-07, Vol.67 (13), p.11226-11241

2024

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Time-Related Differences in the Physical Property Profiles of Oral Drugs

Journal of medicinal chemistry, 2004-12, Vol.47 (25), p.6338-6348

2004

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Quality guidelines for oral drug candidates: dose, solubility and lipophilicity

Drug discovery today, 2016-10, Vol.21 (10), p.1719-1727

2016

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The Time and Place for Nature in Drug Discovery

JACS Au, 2022-11, Vol.2 (11), p.2400-2416

2022

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The Glycine Site on the NMDA Receptor: Structure-Activity Relationships and Therapeutic Potential

Journal of medicinal chemistry, 1994-11, Vol.37 (24), p.4053-4067

1994

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Validity of Ligand Efficiency Metrics

ACS medicinal chemistry letters, 2014-06, Vol.5 (6), p.616-618

2014

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The Design of Leadlike Combinatorial Libraries

Angewandte Chemie (International ed.), 1999-12, Vol.38 (24), p.3743-3748

1999

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Impact of ion class and time on oral drug molecular properties

MedChemComm, 2011-02, Vol.2 (2), p.91-105

2011

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Effect of Plasma Protein Binding on in Vivo Activity and Brain Penetration of Glycine/NMDA Receptor Antagonists

Journal of medicinal chemistry, 1997-12, Vol.40 (25), p.4053-4068

1997

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Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (19), p.5673-5679

2011

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5-(4-Chlorophenyl)-4-methyl-3-(1-(2- phenylethyl)piperidin-4-yl)isoxazole: A Potent, Selective Antagonist at Human Cloned Dopamine D4 Receptors

Journal of medicinal chemistry, 1996-05, Vol.39 (10), p.1943-1945

1996

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Is There a Difference between Leads and Drugs? A Historical Perspective

Journal of Chemical Information and Computer Sciences, 2001-09, Vol.41 (5), p.1308-1315

2001

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3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues: High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2, α3, and α5-Subtype Binding Selectivity over α1

Journal of medicinal chemistry, 2004-03, Vol.47 (7), p.1807-1822

2004

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Molecular inflation, attrition and the rule of five

The influence of drug-like concepts on decision-making in medicinal chemistry

Impact of Physicochemical Properties on Dose and Hepatotoxicity of Oral Drugs

Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations

An analysis of the attrition of drug candidates from four major pharmaceutical companies

The role of ligand efficiency metrics in drug discovery

The influence of the 'organizational factor' on compound quality in drug discovery

A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs

From ATP to AZD6140 : The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis

Target-Based Evaluation of “Drug-Like” Properties and Ligand Efficiencies

Molecular Property Design: Does Everyone Get It?

Occurrence of “Natural Selection” in Successful Small Molecule Drug Discovery

Time-Related Differences in the Physical Property Profiles of Oral Drugs

Quality guidelines for oral drug candidates: dose, solubility and lipophilicity

The Time and Place for Nature in Drug Discovery

The Glycine Site on the NMDA Receptor: Structure-Activity Relationships and Therapeutic Potential

Validity of Ligand Efficiency Metrics

The Design of Leadlike Combinatorial Libraries

Impact of ion class and time on oral drug molecular properties

Effect of Plasma Protein Binding on in Vivo Activity and Brain Penetration of Glycine/NMDA Receptor Antagonists

Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules

5-(4-Chlorophenyl)-4-methyl-3-(1-(2- phenylethyl)piperidin-4-yl)isoxazole: A Potent, Selective Antagonist at Human Cloned Dopamine D4 Receptors

Setting Our Sights on Infectious Diseases

Is There a Difference between Leads and Drugs? A Historical Perspective

3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues: High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2, α3, and α5-Subtype Binding Selectivity over α1

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