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Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation

Reviews in endocrine & metabolic disorders, 2020-12, Vol.21 (4), p.431-447

2020

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Isoform-specific antagonists of exchange proteins directly activated by cAMP

Proceedings of the National Academy of Sciences - PNAS, 2012-11, Vol.109 (45), p.18613-18618

2012

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Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion

Molecular endocrinology (Baltimore, Md.), 2015-07, Vol.29 (7), p.988-1005

2015

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Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag

Molecular endocrinology (Baltimore, Md.), 2013-08, Vol.27 (8), p.1267-1282

2013

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Epac2-Dependent Rap1 Activation and the Control of Islet Insulin Secretion by Glucagon-Like Peptide-1

Incretins and Insulin Secretion, 2010, Vol.84, p.279-302

2010

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Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter

Biochemical and biophysical research communications, 2002-05, Vol.293 (2), p.670-674

2002

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Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon

The Journal of biological chemistry, 2022-02, Vol.298 (2), p.101484-101484, Article 101484

2022

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Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans

Islets, 2011-05, Vol.3 (3), p.121-128

2011

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Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets

Diabetes (New York, N.Y.), 2018-10, Vol.67 (10), p.1999-2011

2018

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The alpha‐7 nicotinic acetylcholine receptor agonist GTS‐21 engages the glucagon‐like peptide‐1 incretin hormone axis to lower levels of blood glucose in db/db mice

Diabetes, obesity & metabolism, 2022-07, Vol.24 (7), p.1255-1266

2022

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Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

The Journal of biological chemistry, 2019-03, Vol.294 (10), p.3514-3531

2019

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“A-kinase” regulator runs amok to provide a paradigm shift in cAMP signaling

The Journal of biological chemistry, 2019-02, Vol.294 (7), p.2247-2248

2019

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The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells

The Journal of clinical investigation, 2010-08, Vol.120 (8), p.2876-2888

2010

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Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways

Cell metabolism, 2023-07, Vol.35 (7), p.1242-1260.e9

2023

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Huntington's Disease of the Endocrine Pancreas: Insulin Deficiency and Diabetes Mellitus due to Impaired Insulin Gene Expression

Neurobiology of disease, 2002-12, Vol.11 (3), p.410-424

2002

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Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors

Scientific reports, 2018-02, Vol.8 (1), p.3749-14, Article 3749

2018

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GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion

Molecular endocrinology (Baltimore, Md.), 2016-06, Vol.30 (6), p.614-629

2016

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Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells

Progress in biophysics and molecular biology, 2011-11, Vol.107 (2), p.236-247

2011

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Stromal Interaction Molecule 1 (STIM1) Regulates ATP-sensitive Potassium (KATP) and Store-operated Ca2+ Channels in MIN6 β-Cells

The Journal of biological chemistry, 2017-02, Vol.292 (6), p.2266-2277

2017

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Interplay between ER Ca2+ Binding Proteins, STIM1 and STIM2, Is Required for Store-Operated Ca2+ Entry

International journal of molecular sciences, 2018-05, Vol.19 (5), p.1522

2018

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Correction: Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

The Journal of biological chemistry, 2019-05, Vol.294 (22), p.8714-8714

2019

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New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice

Biochimica et biophysica acta, 2014-12, Vol.1842 (12), p.2593-2600

2014

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Insulinotropic Hormone Glucagon-Like Peptide-1 Differentiation of Human Pancreatic Islet-Derived Progenitor Cells into Insulin-Producing Cells

Endocrinology (Philadelphia), 2002-08, Vol.143 (8), p.3152-3161

2002

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Synthetic small molecule GLP-1 secretagogues prepared by means of a three-component indole annulation strategy

Scientific reports, 2016-06, Vol.6 (1), p.28934-28934, Article 28934

2016

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Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic β‐cells and rat INS‐1 cells

The Journal of physiology, 2008-03, Vol.586 (5), p.1307-1319

2008

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Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation

Isoform-specific antagonists of exchange proteins directly activated by cAMP

Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion

Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag

Epac2-Dependent Rap1 Activation and the Control of Islet Insulin Secretion by Glucagon-Like Peptide-1

Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter

Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon

Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans

Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets

The alpha‐7 nicotinic acetylcholine receptor agonist GTS‐21 engages the glucagon‐like peptide‐1 incretin hormone axis to lower levels of blood glucose in db/db mice

Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

“A-kinase” regulator runs amok to provide a paradigm shift in cAMP signaling

The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells

Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways

Huntington's Disease of the Endocrine Pancreas: Insulin Deficiency and Diabetes Mellitus due to Impaired Insulin Gene Expression

Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors

GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion

Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells

Stromal Interaction Molecule 1 (STIM1) Regulates ATP-sensitive Potassium (KATP) and Store-operated Ca2+ Channels in MIN6 β-Cells

Interplay between ER Ca2+ Binding Proteins, STIM1 and STIM2, Is Required for Store-Operated Ca2+ Entry

Correction: Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice

Insulinotropic Hormone Glucagon-Like Peptide-1 Differentiation of Human Pancreatic Islet-Derived Progenitor Cells into Insulin-Producing Cells

Synthetic small molecule GLP-1 secretagogues prepared by means of a three-component indole annulation strategy

Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic β‐cells and rat INS‐1 cells

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