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Current research on opioid receptor function

Current drug targets, 2012-02, Vol.13 (2), p.230-246

2012

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Dmt and opioid peptides: A potent alliance

Biopolymers, 2003, Vol.71 (2), p.86-102

2003

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Influence of the Side Chain Next to C-Terminal Benzimidazole in Opioid Pseudopeptides Containing the Dmt-Tic Pharmacophore

Journal of medicinal chemistry, 2009-09, Vol.52 (17), p.5556-5559

2009

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Further Studies on Lead Compounds Containing the Opioid Pharmacophore Dmt-Tic

Journal of medicinal chemistry, 2008-08, Vol.51 (16), p.5109-5117

2008

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Address and Message Sequences for the Nociceptin Receptor: A Structure−Activity Study of Nociceptin-(1−13)-peptide amide

Journal of medicinal chemistry, 1997-06, Vol.40 (12), p.1789-1793

1997

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Structural function of C‐terminal amidation of endomorphin

The FEBS journal, 2005-10, Vol.272 (19), p.5079-5097

2005

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δ-Opioid receptors protect from anoxic disruption of Na⁺ homeostasis via Na⁺ channel regulation

Cellular and molecular life sciences : CMLS, 2009-11, Vol.66 (21), p.3505-3516

2009

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DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortex

Experimental neurology, 2012-08, Vol.236 (2), p.228-239

2012

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Developmental Potential for Endomorphin Opioidmimetic Drugs

International Journal of Medicinal Chemistry (Online), 2012-01, Vol.2012 (2012), p.1-10

2012

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Engineering endomorphin drugs: state of the art

Expert opinion on therapeutic patents, 2012-01, Vol.22 (1), p.1-14

2012

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Endomorphin analogues with balanced affinity for bothμ- andδ-opioid receptors

Chinese chemical letters, 2011-08, Vol.22 (8), p.907-910

2011

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Anxiolytic- and antidepressant-like activities of H-Dmt-Tic-NH-CH(CH 2-COOH)-Bid (UFP-512), a novel selective delta opioid receptor agonist

Peptides (New York, N.Y. : 1980), 2008, Vol.29 (1), p.93-103

2008

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Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides

Bioorganic & medicinal chemistry, 2008-06, Vol.16 (11), p.6286-6296

2008

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Endomorphin analogues with mixed μ-opioid (MOP) receptor agonism/δ-opioid (DOP) receptor antagonism and lacking β-arrestin2 recruitment activity

Bioorganic & medicinal chemistry, 2014-04, Vol.22 (7), p.2208-2219

2014

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Enantioselective Synthesis of a Phenylalanine Library Containing Alkyl Groups on the Aromatic Moiety: Confirmation of Stereostructure by X-Ray Analysis

Chemical and Pharmaceutical Bulletin, 2006, Vol.54(6), pp.873-877

2006

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Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent μ-/δ-opioid receptor antagonist, regulates obese-related factors in mice

European journal of pharmacology, 2009-08, Vol.616 (1-3), p.115-121

2009

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Role of 2′,6′-dimethyl- l-tyrosine (Dmt) in some opioid lead compounds

Bioorganic & medicinal chemistry, 2010-08, Vol.18 (16), p.6024-6030

2010

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Bifunctional [2‘,6‘-Dimethyl-l-tyrosine]endomorphin-2 Analogues Substituted at Position 3 with Alkylated Phenylalanine Derivatives Yield Potent Mixed μ-Agonist/δ-Antagonist and Dual μ-Agonist/δ-Agonist Opioid Ligands

Journal of medicinal chemistry, 2007-06, Vol.50 (12), p.2753-2766

2007

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Studies on the structure-activity relationship of 2', 6'-dimethyl-L-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH3

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.599-602

2005

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Evaluation of the Dmt−Tic Pharmacophore: Conversion of a Potent δ-Opioid Receptor Antagonist into a Potent δ Agonist and Ligands with Mixed Properties

Journal of medicinal chemistry, 2002-01, Vol.45 (3), p.713-720

2002

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A new opioid designed multiple ligand derived from the μ opioid agonist endomorphin-2 and the δ opioid antagonist pharmacophore Dmt-Tic

Bioorganic & medicinal chemistry, 2007-11, Vol.15 (22), p.6876-6881

2007

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6-N,N-Dimethylamino-2,3-naphthalimide: A New Environment-Sensitive Fluorescent Probe in δ- and μ-Selective Opioid Peptides

Journal of medicinal chemistry, 2006-06, Vol.49 (12), p.3653-3658

2006

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Synthesis and Pharmacological Activity of Deltorphin and Dermorphin-Related Glycopeptides

Journal of medicinal chemistry, 1997-08, Vol.40 (18), p.2948-2952

1997

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Potent δ-Opioid Receptor Agonists Containing the Dmt−Tic Pharmacophore

Journal of medicinal chemistry, 2002-12, Vol.45 (25), p.5556-5563

2002

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Evolution of the Bifunctional Lead μ Agonist/δ Antagonist Containing the 2′,6′-Dimethyl- l -tyrosine−1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Dmt−Tic) Opioid Pharmacophore

ACS chemical neuroscience, 2009-11, Vol.1 (2), p.155-164

2009

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Current research on opioid receptor function

Dmt and opioid peptides: A potent alliance

Influence of the Side Chain Next to C-Terminal Benzimidazole in Opioid Pseudopeptides Containing the Dmt-Tic Pharmacophore

Further Studies on Lead Compounds Containing the Opioid Pharmacophore Dmt-Tic

Address and Message Sequences for the Nociceptin Receptor: A Structure−Activity Study of Nociceptin-(1−13)-peptide amide

Structural function of C‐terminal amidation of endomorphin

δ-Opioid receptors protect from anoxic disruption of Na⁺ homeostasis via Na⁺ channel regulation

DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortex

Developmental Potential for Endomorphin Opioidmimetic Drugs

Engineering endomorphin drugs: state of the art

Endomorphin analogues with balanced affinity for bothμ- andδ-opioid receptors

Anxiolytic- and antidepressant-like activities of H-Dmt-Tic-NH-CH(CH 2-COOH)-Bid (UFP-512), a novel selective delta opioid receptor agonist

Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides

Endomorphin analogues with mixed μ-opioid (MOP) receptor agonism/δ-opioid (DOP) receptor antagonism and lacking β-arrestin2 recruitment activity

Enantioselective Synthesis of a Phenylalanine Library Containing Alkyl Groups on the Aromatic Moiety: Confirmation of Stereostructure by X-Ray Analysis

Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent μ-/δ-opioid receptor antagonist, regulates obese-related factors in mice

Role of 2′,6′-dimethyl- l-tyrosine (Dmt) in some opioid lead compounds

Bifunctional [2‘,6‘-Dimethyl-l-tyrosine]endomorphin-2 Analogues Substituted at Position 3 with Alkylated Phenylalanine Derivatives Yield Potent Mixed μ-Agonist/δ-Antagonist and Dual μ-Agonist/δ-Agonist Opioid Ligands

Studies on the structure-activity relationship of 2', 6'-dimethyl-L-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH3

Evaluation of the Dmt−Tic Pharmacophore: Conversion of a Potent δ-Opioid Receptor Antagonist into a Potent δ Agonist and Ligands with Mixed Properties

A new opioid designed multiple ligand derived from the μ opioid agonist endomorphin-2 and the δ opioid antagonist pharmacophore Dmt-Tic

6-N,N-Dimethylamino-2,3-naphthalimide: A New Environment-Sensitive Fluorescent Probe in δ- and μ-Selective Opioid Peptides

Synthesis and Pharmacological Activity of Deltorphin and Dermorphin-Related Glycopeptides

Potent δ-Opioid Receptor Agonists Containing the Dmt−Tic Pharmacophore

Evolution of the Bifunctional Lead μ Agonist/δ Antagonist Containing the 2′,6′-Dimethyl- l -tyrosine−1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Dmt−Tic) Opioid Pharmacophore

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