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2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.3172-3176

2011

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Alkyl substituted aminal derivatives of HCV NS5A inhibitor MK-8742

Bioorganic & medicinal chemistry letters, 2016-08, Vol.26 (15), p.3800-3805

2016

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Antibody catalyzed hydrolysis of a phosphotriester

Bioorganic & medicinal chemistry letters, 1996-07, Vol.6 (13), p.1523-1524

1996

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Biaryl substituted hydantoin compounds as TACE inhibitors

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (17), p.5286-5289

2010

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Cannabinoid CB 2 -Selective Inverse Agonist Protects Against Antigen-Induced Bone Loss

Immunopharmacology and immunotoxicology, 2007-01, Vol.29 (3-4), p.387-401

2007

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Cannabinoid CB(2)-selective inverse agonist protects against antigen-induced bone loss

Immunopharmacology and immunotoxicology, 2007, Vol.29 (3-4), p.387

2007

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Cannabinoid CB2-Selective Inverse Agonist Protects Against Antigen-Induced Bone Loss

Immunopharmacology and immunotoxicology, 2007-01, Vol.29 (3-4), p.387-401

2007

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Catalytic Antibody Mediated Hydrolysis of Paraoxon

Journal of organic chemistry, 1996-10, Vol.61 (21), p.7633-7636

1996

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Characterization of Peripheral Human Cannabinoid Receptor (hCB2) Expression and Pharmacology Using a Novel Radioligand, [35S]Sch225336

The Journal of biological chemistry, 2006-09, Vol.281 (38), p.28143-28151

2006

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Direct Selection for Catalysis from Combinatorial Antibody Libraries Using a Boronic Acid Probe: Primary Amide Bond Hydrolysis

Journal of the American Chemical Society, 1998-03, Vol.120 (10), p.2211-2217

1998

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Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4

Bioorganic & medicinal chemistry letters, 2015-05, Vol.25 (9), p.1836-1841

2015

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Discovery and SAR of hydantoin TACE inhibitors

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (6), p.1877-1880

2010

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Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors

ACS medicinal chemistry letters, 2015-08, Vol.6 (8), p.942-947

2015

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The Discovery of N‑((2H‑Tetrazol-5-yl)methyl)-4-((R)‑1-((5r,8R)‑8‑(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2601-2610

2014

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Discovery of novel hydroxamates as highly potent tumor necrosis factor-a converting enzyme inhibitors. Part II: Optimization of the S3' pocket

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (21), p.5809-5814

2008

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Discovery of novel hydroxamates as highly potent tumor necrosis factor-[alpha] converting enzyme inhibitors. Part II: Optimization of the S3′ pocket

Bioorganic & medicinal chemistry letters, 2010-10, Vol.18 ((21) ; 11, 2008)

2010

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Discovery of novel hydroxamates as highly potent tumor necrosis factor-α converting enzyme inhibitors. Part II: Optimization of the S3′ pocket

Bioorganic & medicinal chemistry, 2008-11, Vol.18 (21), p.5809-5814

2008

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Discovery of novel spirocyclopropyl hydroxamate and carboxylate compounds as TACE inhibitors

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (1), p.54-57

2009

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The discovery of novel tartrate-based TNF-a converting enzyme (TACE) inhibitors

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (3), p.1189-1193

2010

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The discovery of novel tartrate-based TNF-α converting enzyme (TACE) inhibitors

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.1189-1193

2010

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Labelling and biological evaluation of [11 C]methoxy-Sch225336: a radioligand for the cannabinoid-type 2 receptor

Nuclear medicine and biology, 2008-10, Vol.35 (7), p.793-800

2008

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Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors

Bioorganic & medicinal chemistry letters, 2016-08, Vol.26 (16), p.4106-4111

2016

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Mycoplasmoides genitalium nucleic acid semi-quantitation and molecular macrolide resistance detection via automated assays: gender and specimen source considerations

Journal of clinical microbiology, 2024-06, Vol.62 (6), p.e0048524

2024

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A new synthetic route to B-ring derivatives of TMD

Lavey, Brian John

1994

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Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.608-611

2010

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2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors

Alkyl substituted aminal derivatives of HCV NS5A inhibitor MK-8742

Antibody catalyzed hydrolysis of a phosphotriester

Biaryl substituted hydantoin compounds as TACE inhibitors

Cannabinoid CB 2 -Selective Inverse Agonist Protects Against Antigen-Induced Bone Loss

Cannabinoid CB(2)-selective inverse agonist protects against antigen-induced bone loss

Cannabinoid CB2-Selective Inverse Agonist Protects Against Antigen-Induced Bone Loss

Catalytic Antibody Mediated Hydrolysis of Paraoxon

Characterization of Peripheral Human Cannabinoid Receptor (hCB2) Expression and Pharmacology Using a Novel Radioligand, [35S]Sch225336

Direct Selection for Catalysis from Combinatorial Antibody Libraries Using a Boronic Acid Probe: Primary Amide Bond Hydrolysis

Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4

Discovery and SAR of hydantoin TACE inhibitors

Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors

The Discovery of N‑((2H‑Tetrazol-5-yl)methyl)-4-((R)‑1-((5r,8R)‑8‑(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist

Discovery of novel hydroxamates as highly potent tumor necrosis factor-a converting enzyme inhibitors. Part II: Optimization of the S3' pocket

Discovery of novel hydroxamates as highly potent tumor necrosis factor-[alpha] converting enzyme inhibitors. Part II: Optimization of the S3′ pocket

Discovery of novel hydroxamates as highly potent tumor necrosis factor-α converting enzyme inhibitors. Part II: Optimization of the S3′ pocket

Discovery of novel spirocyclopropyl hydroxamate and carboxylate compounds as TACE inhibitors

The discovery of novel tartrate-based TNF-a converting enzyme (TACE) inhibitors

The discovery of novel tartrate-based TNF-α converting enzyme (TACE) inhibitors

Labelling and biological evaluation of [11 C]methoxy-Sch225336: a radioligand for the cannabinoid-type 2 receptor

Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors

Mycoplasmoides genitalium nucleic acid semi-quantitation and molecular macrolide resistance detection via automated assays: gender and specimen source considerations

A new synthetic route to B-ring derivatives of TMD

Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors

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