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Peroxisome protein import: a complex journey

Biochemical Society transactions, 2016-06, Vol.44 (3), p.783

2016

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Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)

Angewandte Chemie (International ed.), 2021-06, Vol.60 (24), p.13542-13547

International ed. in English, 2021

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Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets

Trends in biochemical sciences (Amsterdam. Regular ed.), 2017-07, Vol.42 (7), p.566-581

2017

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Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)

Angewandte Chemie, 2021-06, Vol.133 (24), p.13654-13659

2021

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Global profiling of protein lipidation using chemical proteomic technologies

Current opinion in chemical biology, 2015-02, Vol.24, p.48-57

2015

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Topological Analysis of Hedgehog Acyltransferase, a Multipalmitoylated Transmembrane Protein

The Journal of biological chemistry, 2015-02, Vol.290 (6), p.3293-3307

2015

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Getting a camel through the eye of a needle: the import of folded proteins by peroxisomes

Biology of the cell, 2010-04, Vol.102 (4), p.245-263

2010

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Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane

Chemical communications (Cambridge, England), 2017, Vol.53 (37), p.5182-5185

2017

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Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells

ACS chemical biology, 2016-12, Vol.11 (12), p.3256-3262

2016

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Synthesis of Small Molecules with High Scaffold Diversity: Exploitation of Metathesis Cascades in Combination with Inter- and Intramolecular Diels-Alder Reactions

Chemistry : a European journal, 2010-08, Vol.16 (31), p.9563-9571

2010

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Targeting the bacterial SOS response for new antimicrobial agents: drug targets, molecular mechanisms and inhibitors

Future medicinal chemistry, 2021-01, Vol.13 (2), p.143-155

Lanyon-Hogg, Thomas

2021

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Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase

Data in brief, 2016-06, Vol.7, p.257-281

2016

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Evaluating Hedgehog Acyltransferase Activity and Inhibition Using the Acylation-coupled Lipophilic Induction of Polarization (Acyl-cLIP) Assay

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2374, p.13

2022

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Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation

Nature protocols, 2021-11, Vol.16 (11), p.5083-5122

2021

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Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics

Nature chemistry, 2019-06, Vol.11 (6), p.552

2019

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Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity

Journal of the American Chemical Society, 2020-07, Vol.142 (28), p.12020-12026

2020

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Structure, mechanism, and inhibition of Hedgehog acyltransferase

Molecular cell, 2021-12, Vol.81 (24), p.5025-5038.e10

2021

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Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase

Journal of medicinal chemistry, 2024-01, Vol.67 (2), p.1061-1078

2024

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PEX14 binding to Arabidopsis PEX5 has differential effects on PTS1 and PTS2 cargo occupancy of the receptor

FEBS letters, 2014-06, Vol.588 (14), p.2223-2229

2014

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Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes

Chemical science (Cambridge), 2019-10, Vol.1 (39), p.8995-9

2019

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Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus

Bioorganic & medicinal chemistry, 2019-10, Vol.27 (20), p.114962, Article 114962

2019

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Modulation of Amide Bond Rotamers in 5‑Acyl-6,7-dihydrothieno[3,2‑c]pyridines

Journal of organic chemistry, 2015-05, Vol.80 (9), p.4370-4377

2015

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Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphaneElectronic supplementary information (ESI) available: ProteomeXchange with identifier PXD006279. See DOI: 10.1039/c6cc08797c

2017-05

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Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane† †Electronic supplementary information (ESI) available: ProteomeXchange with identifier PXD006279. See DOI: 10.1039/c6cc08797c

Chemical communications (Cambridge, England), 2017-04, Vol.53 (37), p.5182-5185

2017

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Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase

Analytical biochemistry, 2015-12, Vol.490, p.66-72

2015

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Peroxisome protein import: a complex journey

Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)

Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets

Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)

Global profiling of protein lipidation using chemical proteomic technologies

Topological Analysis of Hedgehog Acyltransferase, a Multipalmitoylated Transmembrane Protein

Getting a camel through the eye of a needle: the import of folded proteins by peroxisomes

Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane

Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells

Synthesis of Small Molecules with High Scaffold Diversity: Exploitation of Metathesis Cascades in Combination with Inter- and Intramolecular Diels-Alder Reactions

Targeting the bacterial SOS response for new antimicrobial agents: drug targets, molecular mechanisms and inhibitors

Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase

Evaluating Hedgehog Acyltransferase Activity and Inhibition Using the Acylation-coupled Lipophilic Induction of Polarization (Acyl-cLIP) Assay

Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation

Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics

Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity

Structure, mechanism, and inhibition of Hedgehog acyltransferase

Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase

PEX14 binding to Arabidopsis PEX5 has differential effects on PTS1 and PTS2 cargo occupancy of the receptor

Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes

Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus

Modulation of Amide Bond Rotamers in 5‑Acyl-6,7-dihydrothieno[3,2‑c]pyridines

Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphaneElectronic supplementary information (ESI) available: ProteomeXchange with identifier PXD006279. See DOI: 10.1039/c6cc08797c

Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane† †Electronic supplementary information (ESI) available: ProteomeXchange with identifier PXD006279. See DOI: 10.1039/c6cc08797c

Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase

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