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Use of PET Imaging to Evaluate Transporter-Mediated Drug-Drug Interactions

Journal of clinical pharmacology, 2016-07, Vol.56 (S7), p.S143-S156

Langer, Oliver

2016

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Preclinical Evaluation of [18F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters

Contrast media and molecular imaging, 2018-01, Vol.2018 (2018), p.1-10

2018

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Phase 0/microdosing approaches: time for mainstream application in drug development?

Nature reviews. Drug discovery, 2020-11, Vol.19 (11), p.801-818

2020

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Alzheimer’s and ABC transporters — new opportunities for diagnostics and treatment

Neurobiology of disease, 2014-12, Vol.72, p.54-60

2014

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Approaches using molecular imaging technology — use of PET in clinical microdose studies

Advanced drug delivery reviews, 2011-06, Vol.63 (7), p.539-546

2011

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Blood-brain barrier P-glycoprotein function in Alzheimer's disease

Brain (London, England : 1878), 2012-01, Vol.135 (1), p.181-189

2012

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Approaching Complete Inhibition of P-Glycoprotein at the Human Blood–Brain Barrier: An (R)-[11C]Verapamil PET Study

Journal of cerebral blood flow and metabolism, 2015-05, Vol.35 (5), p.743-746

2015

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P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study

Lancet neurology, 2013-08, Vol.12 (8), p.777-785

2013

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A Proof-of-Concept Study to Inhibit ABCG2- and ABCB1-Mediated Efflux Transport at the Human Blood-Brain Barrier

Journal of Nuclear Medicine, 2019-04, Vol.60 (4), p.486-491

2019

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Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study

Drug metabolism and disposition, 2013-04, Vol.41 (4), p.754-762

2013

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PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo

Current drug metabolism, 2011-10, Vol.12 (8), p.774-792

2011

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Effect of P‐glycoprotein inhibition at the blood–brain barrier on brain distribution of (R)‐[11C]verapamil in elderly vs. young subjects

British journal of clinical pharmacology, 2017-09, Vol.83 (9), p.1991-1999

2017

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Strategic, feasibility, economic, and cultural aspects of phase 0 approaches

Clinical and translational science, 2022-06, Vol.15 (6), p.1355-1379

2022

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Use of PET Imaging to Assess the Efficacy of Thiethylperazine to Stimulate Cerebral MRP1 Transport Activity in Wild-Type and APP/PS1-21 Mice

International journal of molecular sciences, 2022-06, Vol.23 (12), p.6514

2022

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Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier

Journal of labelled compounds & radiopharmaceuticals, 2013-03, Vol.56 (3-4), p.68-77

2013

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In vivo P-glycoprotein function before and after epilepsy surgery

Neurology, 2014-10, Vol.83 (15), p.1326-1331

2014

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EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling

EMBO molecular medicine, 2018-11, Vol.10 (11), p.1-n/a

2018

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[ 11 C]Metoclopramide PET can detect a seizure-induced up-regulation of cerebral P-glycoprotein in epilepsy patients

Fluids and barriers of the CNS, 2024-10, Vol.21 (1), p.87-12, Article 87

2024

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Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model

International journal of molecular sciences, 2020-11, Vol.21 (21), p.8245

2020

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Imaging of P-glycoprotein function and expression to elucidate mechanisms of pharmacoresistance in epilepsy

Current topics in medicinal chemistry, 2010-12, Vol.10 (17), p.1785-1791

2010

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P-Glycoprotein (ABCB1) Inhibits the Influx and Increases the Efflux of 11C-Metoclopramide Across the Blood-Brain Barrier: A PET Study on Nonhuman Primates

The Journal of nuclear medicine (1978), 2018-10, Vol.59 (10), p.1609-1615

2018

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Effect of Rifampicin on the Distribution of [11C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice

Molecular pharmaceutics, 2018-10, Vol.15 (10), p.4589-4598

2018

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Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[11C]verapamil PET

European journal of nuclear medicine and molecular imaging, 2010-05, Vol.37 (5), p.942-953

2010

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Characterization of an APP/tau rat model of Alzheimer's disease by positron emission tomography and immunofluorescent labeling

Alzheimer's research & therapy, 2021-10, Vol.13 (1), p.175-175, Article 175

2021

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ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C> A) May Lead to Increased Drug Exposure

Frontiers in pharmacology, 2021-06, Vol.12, p.698966-698966

2021

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Use of PET Imaging to Evaluate Transporter-Mediated Drug-Drug Interactions

Preclinical Evaluation of [18F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters

Phase 0/microdosing approaches: time for mainstream application in drug development?

Alzheimer’s and ABC transporters — new opportunities for diagnostics and treatment

Approaches using molecular imaging technology — use of PET in clinical microdose studies

Blood-brain barrier P-glycoprotein function in Alzheimer's disease

Approaching Complete Inhibition of P-Glycoprotein at the Human Blood–Brain Barrier: An (R)-[11C]Verapamil PET Study

P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study

A Proof-of-Concept Study to Inhibit ABCG2- and ABCB1-Mediated Efflux Transport at the Human Blood-Brain Barrier

Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study

PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo

Effect of P‐glycoprotein inhibition at the blood–brain barrier on brain distribution of (R)‐[11C]verapamil in elderly vs. young subjects

Strategic, feasibility, economic, and cultural aspects of phase 0 approaches

Use of PET Imaging to Assess the Efficacy of Thiethylperazine to Stimulate Cerebral MRP1 Transport Activity in Wild-Type and APP/PS1-21 Mice

Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier

In vivo P-glycoprotein function before and after epilepsy surgery

EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling

[ 11 C]Metoclopramide PET can detect a seizure-induced up-regulation of cerebral P-glycoprotein in epilepsy patients

Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model

Imaging of P-glycoprotein function and expression to elucidate mechanisms of pharmacoresistance in epilepsy

P-Glycoprotein (ABCB1) Inhibits the Influx and Increases the Efflux of 11C-Metoclopramide Across the Blood-Brain Barrier: A PET Study on Nonhuman Primates

Effect of Rifampicin on the Distribution of [11C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[11C]verapamil PET

Characterization of an APP/tau rat model of Alzheimer's disease by positron emission tomography and immunofluorescent labeling

ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C> A) May Lead to Increased Drug Exposure

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