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Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis

The Journal of clinical investigation, 2002-10, Vol.110 (7), p.1045-1052

2002

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Registration and fusion of retinal images-an evaluation study

IEEE transactions on medical imaging, 2003-05, Vol.22 (5), p.661-673

2003

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The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (18), p.5502-5505

2010

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Optimization and structure–activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: Identification of MK-0873, a potent and effective PDE4 inhibitor

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (20), p.5554-5558

2008

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Conformational Difference between PDE4 Apoenzyme and Holoenzyme

Biochemistry (Easton), 2000-05, Vol.39 (21), p.6449-6458

2000

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Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2

Biochemistry (Easton), 1993-06, Vol.32 (23), p.5935-5940

1993

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Optimization of a Tertiary Alcohol Series of Phosphodiesterase-4 (PDE4) Inhibitors: Structure−Activity Relationship Related to PDE4 Inhibition and Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2413-2426

2003

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Design, synthesis, and biological evaluation of 8-biarylquinolines: A novel class of PDE4 inhibitors

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (4), p.1407-1412

2008

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Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5266-5269

2009

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Discovery of L-791,943: A potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor

Bioorganic & medicinal chemistry letters, 2002-06, Vol.12 (11), p.1457-1461

2002

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Abstract 2766: Automation of linear range determination: Enzymatic progress curve applications

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.2766-2766

2023

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Hunting the Emesis and Efficacy Targets of PDE4 Inhibitors: Identification of the Photoaffinity Probe 8-(3-Azidophenyl)-6- [(4-iodo-1H-1-imidazolyl)methyl]quinoline (APIIMQ)

Journal of medicinal chemistry, 2000-10, Vol.43 (21), p.3820-3823

2000

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Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis

The Journal of clinical investigation, 2002-10, Vol.110 (7), p.1045-1052

2002

Volltextzugriff (PDF)

Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (10), p.2608-2612

2006

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Substituted 4-(2,2-diphenylethyl)pyridine-n-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters

Bioorganic & medicinal chemistry letters, 2002-10, Vol.12 (20), p.3009-3013

2002

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Substituted 2-Pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors

Bioorganic & medicinal chemistry letters, 2003-06, Vol.13 (11), p.1923-1926

2003

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Substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (4), p.741-744

2003

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A protein engineering study of the role of aspartate 158 in the catalytic mechanism of papain

Biochemistry (Easton), 1990-07, Vol.29 (28), p.6706-6713

1990

Volltextzugriff (PDF)

Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets

The Journal of biological chemistry, 1994-06, Vol.269 (22), p.15619-15624

1994

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Dynamic activation of cystic fibrosis transmembrane conductance regulator by type 3 and type 4D phosphodiesterase inhibitors

The Journal of pharmacology and experimental therapeutics, 2005-08, Vol.314 (2), p.846

2005

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Dissecting the Cofactor-Dependent and Independent Bindings of PDE4 Inhibitors

Biochemistry (Easton), 2001-08, Vol.40 (34), p.10179-10186

2001

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In vitro PKA phosphorylation-mediated human PDE4A4 activation

FEBS letters, 2002-02, Vol.512 (1), p.205-208

2002

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Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters

Bioorganic & medicinal chemistry letters, 2002-10, Vol.12 (20), p.3009

2002

Volltextzugriff (PDF)

Endothelin expression in human megakaryoblastic leukemia cell lines and normal platelet precursors

Regulatory peptides, 1997-01, Vol.68 (2), p.91-97

1997

Volltextzugriff (PDF)

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Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis

Registration and fusion of retinal images-an evaluation study

The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors

Optimization and structure–activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: Identification of MK-0873, a potent and effective PDE4 inhibitor

Conformational Difference between PDE4 Apoenzyme and Holoenzyme

Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2

Optimization of a Tertiary Alcohol Series of Phosphodiesterase-4 (PDE4) Inhibitors: Structure−Activity Relationship Related to PDE4 Inhibition and Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity

Design, synthesis, and biological evaluation of 8-biarylquinolines: A novel class of PDE4 inhibitors

Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors

Discovery of L-791,943: A potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor

Abstract 2766: Automation of linear range determination: Enzymatic progress curve applications

Hunting the Emesis and Efficacy Targets of PDE4 Inhibitors: Identification of the Photoaffinity Probe 8-(3-Azidophenyl)-6- [(4-iodo-1H-1-imidazolyl)methyl]quinoline (APIIMQ)

Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis

Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors

Substituted 4-(2,2-diphenylethyl)pyridine-n-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters

Substituted 2-Pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors

Substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors

A protein engineering study of the role of aspartate 158 in the catalytic mechanism of papain

Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets

Dynamic activation of cystic fibrosis transmembrane conductance regulator by type 3 and type 4D phosphodiesterase inhibitors

Dissecting the Cofactor-Dependent and Independent Bindings of PDE4 Inhibitors

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor

In vitro PKA phosphorylation-mediated human PDE4A4 activation

Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters

Endothelin expression in human megakaryoblastic leukemia cell lines and normal platelet precursors

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