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Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)

Journal of medicinal chemistry, 2017-12, Vol.60 (24), p.9960-9973

2017

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Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

Nature medicine, 2003-02, Vol.9 (2), p.213-219

2003

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LXRs Control Lipid-Inducible Expression of the Apolipoprotein E Gene in Macrophages and Adipocytes

Proceedings of the National Academy of Sciences - PNAS, 2001-01, Vol.98 (2), p.507-512

2001

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Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells

PloS one, 2020, Vol.15 (3), p.e0224344-e0224344

2020

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Direct and Indirect Mechanisms for Regulation of Fatty Acid Synthase Gene Expression by Liver X Receptors

The Journal of biological chemistry, 2002-03, Vol.277 (13), p.11019-11025

2002

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Liver X receptor modulators: a review of recently patented compounds (2009 - 2012)

Expert opinion on therapeutic patents, 2013-10, Vol.23 (10), p.1317-1335

2013

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Synthetic LXR Ligand Inhibits the Development of Atherosclerosis in Mice

Proceedings of the National Academy of Sciences - PNAS, 2002-05, Vol.99 (11), p.7604-7609

2002

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Activation of Liver X Receptor Improves Glucose Tolerance through Coordinate Regulation of Glucose Metabolism in Liver and Adipose Tissue

Proceedings of the National Academy of Sciences - PNAS, 2003-04, Vol.100 (9), p.5419-5424

2003

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Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening

Journal of the American Chemical Society, 2013-02, Vol.135 (5), p.1669-1672

2013

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Identification of Macrophage Liver X Receptors as Inhibitors of Atherosclerosis

Proceedings of the National Academy of Sciences - PNAS, 2002-09, Vol.99 (18), p.11896-11901

2002

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Tropifexor‐Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents

Hepatology communications, 2019-08, Vol.3 (8), p.1085-1097

2019

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Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth

Oncotarget, 2013-12, Vol.4 (12), p.2502-2511

2013

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Farnesoid X-Activated Receptor Induces Apolipoprotein C-II Transcription: a Molecular Mechanism Linking Plasma Triglyceride Levels to Bile Acids

Molecular endocrinology (Baltimore, Md.), 2001-10, Vol.15 (10), p.1720-1728

2001

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Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids

Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (11), p.4337-4342

2009

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The Phospholipid Transfer Protein Gene Is a Liver X Receptor Target Expressed by Macrophages in Atherosclerotic Lesions

Molecular and Cellular Biology, 2003-03, Vol.23 (6), p.2182-2191

2003

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Screening the Mammalian Extracellular Proteome for Regulators of Embryonic Human Stem Cell Pluripotency

Proceedings of the National Academy of Sciences - PNAS, 2010-02, Vol.107 (8), p.3552-3557

2010

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Control of Cellular Cholesterol Efflux by the Nuclear Oxysterol Receptor LXRα

Proceedings of the National Academy of Sciences - PNAS, 2000-10, Vol.97 (22), p.12097-12102

2000

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Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta

The Journal of biological chemistry, 2002-08, Vol.277 (35), p.31900-31908

2002

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Autoregulation of the Human Liver X Receptor α Promoter

Molecular and Cellular Biology, 2001-11, Vol.21 (22), p.7558-7568

2001

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Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target

Journal of lipid research, 2004-04, Vol.45 (4), p.616-625

2004

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Transcription of the Vascular Endothelial Growth Factor Gene in Macrophages Is Regulated by Liver X Receptors

The Journal of biological chemistry, 2004-03, Vol.279 (11), p.9905-9911

2004

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Structure-Guided Design of N-Phenyl Tertiary Amines as Transrepression-Selective Liver X Receptor Modulators with Anti-Inflammatory Activity

Journal of medicinal chemistry, 2008-09, Vol.51 (18), p.5758-5765

2008

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Discovery of 5‑(3,4-Difluorophenyl)-3-(pyrazol-4-yl)-7-azaindole (GNF3809) for β‑Cell Survival in Type 1 Diabetes

ACS omega, 2019-02, Vol.4 (2), p.3571-3581

2019

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Identification of the DNA Binding Specificity and Potential Target Genes for the Farnesoid X-activated Receptor

The Journal of biological chemistry, 2000-04, Vol.275 (14), p.10638-10647

2000

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Correction to “Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening”

Journal of the American Chemical Society, 2013-03, Vol.135 (11), p.4573-4573

2013

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Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

LXRs Control Lipid-Inducible Expression of the Apolipoprotein E Gene in Macrophages and Adipocytes

Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells

Direct and Indirect Mechanisms for Regulation of Fatty Acid Synthase Gene Expression by Liver X Receptors

Liver X receptor modulators: a review of recently patented compounds (2009 - 2012)

Synthetic LXR Ligand Inhibits the Development of Atherosclerosis in Mice

Activation of Liver X Receptor Improves Glucose Tolerance through Coordinate Regulation of Glucose Metabolism in Liver and Adipose Tissue

Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening

Identification of Macrophage Liver X Receptors as Inhibitors of Atherosclerosis

Tropifexor‐Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents

Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth

Farnesoid X-Activated Receptor Induces Apolipoprotein C-II Transcription: a Molecular Mechanism Linking Plasma Triglyceride Levels to Bile Acids

Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids

The Phospholipid Transfer Protein Gene Is a Liver X Receptor Target Expressed by Macrophages in Atherosclerotic Lesions

Screening the Mammalian Extracellular Proteome for Regulators of Embryonic Human Stem Cell Pluripotency

Control of Cellular Cholesterol Efflux by the Nuclear Oxysterol Receptor LXRα

Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta

Autoregulation of the Human Liver X Receptor α Promoter

Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target

Transcription of the Vascular Endothelial Growth Factor Gene in Macrophages Is Regulated by Liver X Receptors

Structure-Guided Design of N-Phenyl Tertiary Amines as Transrepression-Selective Liver X Receptor Modulators with Anti-Inflammatory Activity

Discovery of 5‑(3,4-Difluorophenyl)-3-(pyrazol-4-yl)-7-azaindole (GNF3809) for β‑Cell Survival in Type 1 Diabetes

Identification of the DNA Binding Specificity and Potential Target Genes for the Farnesoid X-activated Receptor

Correction to “Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening”

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