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Post-translational regulation of the major drug transporters in the families of organic anion transporters and organic anion–transporting polypeptides

The Journal of biological chemistry, 2020-12, Vol.295 (50), p.17349-17364

2020

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Next-generation proteasome inhibitors for cancer therapy

Translational research : the journal of laboratory and clinical medicine, 2018-08, Vol.198, p.1-16

2018

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Cancer specific transporters for diagnosis and chemotherapy

Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S14-S14

Lee, Wooin

2017

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Phase 0/microdosing approaches: time for mainstream application in drug development?

Nature reviews. Drug discovery, 2020-11, Vol.19 (11), p.801-818

2020

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Experimental and Modeling Evidence Supporting the Trans -Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A

Drug metabolism and disposition, 2022-05, Vol.50 (5), p.541-551

2022

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Predicting In Vivo Target Occupancy (TO) Profiles via Physiologically Based Pharmacokinetic–TO Modeling of Warfarin Pharmacokinetics in Blood: Importance of Low Dose Data and Prediction of Stereoselective Target Interactions

Drug metabolism and disposition, 2023-09, Vol.51 (9), p.1145-1156

2023

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Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy

The AAPS journal, 2015-05, Vol.17 (3), p.535-545

2015

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Consideration of albumin-mediated hepatic uptake for highly protein-bound anionic drugs: Bridging the gap of hepatic uptake clearance between in vitro and in vivo

Pharmacology & therapeutics (Oxford), 2022-01, Vol.229, p.107938-107938, Article 107938

2022

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Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection

PloS one, 2012-02, Vol.7 (2), p.e32273-e32273

2012

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Physiologically Based Pharmacokinetic Modeling of Bosentan Identifies the Saturable Hepatic Uptake As a Major Contributor to Its Nonlinear Pharmacokinetics

Drug metabolism and disposition, 2018-05, Vol.46 (5), p.740-748

2018

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Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids

Cancer research (Chicago, Ill.), 2014-04, Vol.74 (7), p.2062-2072

2014

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Transient, Tunable Expression of NTCP and BSEP in MDCKII Cells for Kinetic Delineation of the Rate-Determining Process and Inhibitory Effects of Rifampicin in Hepatobiliary Transport of Taurocholate

Journal of pharmaceutical sciences, 2021-01, Vol.110 (1), p.365-375

2021

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Drug and Bile Acid Transporters in Rosuvastatin Hepatic Uptake: Function, Expression, and Pharmacogenetics

Gastroenterology (New York, N.Y. 1943), 2006-05, Vol.130 (6), p.1793-1806

2006

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Inhibitors of the immunoproteasome: current status and future directions

Current pharmaceutical design, 2013, Vol.19 (22), p.4140-4151

2013

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Strategies to improve the prediction accuracy of hepatic intrinsic clearance of three antidiabetic drugs: Application of the extended clearance concept and consideration of the effect of albumin on CYP2C metabolism and OATP1B-mediated hepatic uptake

European journal of pharmaceutical sciences, 2018-12, Vol.125, p.181-192

2018

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Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter–Mediated Interactions Between Metformin and Cimetidine

CPT: pharmacometrics and systems pharmacology, 2019-06, Vol.8 (6), p.396-406

2019

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Transporters and renal drug elimination

Annual review of pharmacology and toxicology, 2004-01, Vol.44 (1), p.137-166

2004

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Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug‐Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects

CPT: pharmacometrics and systems pharmacology, 2018-03, Vol.7 (3), p.186-196

2018

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Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice

Frontiers in pharmacology, 2024-03, Vol.15, p.1352842-1352842

2024

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Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction

CPT: pharmacometrics and systems pharmacology, 2019-11, Vol.8 (11), p.845-857

2019

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A Cancer-Specific Variant of the SLCO1B3 Gene Encodes a Novel Human Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Localized Mainly in the Cytoplasm of Colon and Pancreatic Cancer Cells

Molecular pharmaceutics, 2013-01, Vol.10 (1), p.406-416

2013

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Morpholino-mediated increase in soluble Flt-1 expression results in decreased ocular and tumor neovascularization

PloS one, 2012-03, Vol.7 (3), p.e33576-e33576

2012

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Polymer micelle formulation for the proteasome inhibitor drug carfilzomib: Anticancer efficacy and pharmacokinetic studies in mice

PloS one, 2017-03, Vol.12 (3), p.e0173247-e0173247

2017

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The N-terminal region of organic anion transporting polypeptide 1B3 (OATP1B3) plays an essential role in regulating its plasma membrane trafficking

Biochemical pharmacology, 2017-05, Vol.131, p.98-105

2017

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Semi-quantitative parameter analysis of DCE-MRI revisited: monte-carlo simulation, clinical comparisons, and clinical validation of measurement errors in patients with type 2 neurofibromatosis

PloS one, 2014-03, Vol.9 (3), p.e90300-e90300

2014

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Post-translational regulation of the major drug transporters in the families of organic anion transporters and organic anion–transporting polypeptides

Next-generation proteasome inhibitors for cancer therapy

Cancer specific transporters for diagnosis and chemotherapy

Phase 0/microdosing approaches: time for mainstream application in drug development?

Experimental and Modeling Evidence Supporting the Trans -Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A

Predicting In Vivo Target Occupancy (TO) Profiles via Physiologically Based Pharmacokinetic–TO Modeling of Warfarin Pharmacokinetics in Blood: Importance of Low Dose Data and Prediction of Stereoselective Target Interactions

Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy

Consideration of albumin-mediated hepatic uptake for highly protein-bound anionic drugs: Bridging the gap of hepatic uptake clearance between in vitro and in vivo

Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection

Physiologically Based Pharmacokinetic Modeling of Bosentan Identifies the Saturable Hepatic Uptake As a Major Contributor to Its Nonlinear Pharmacokinetics

Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids

Transient, Tunable Expression of NTCP and BSEP in MDCKII Cells for Kinetic Delineation of the Rate-Determining Process and Inhibitory Effects of Rifampicin in Hepatobiliary Transport of Taurocholate

Drug and Bile Acid Transporters in Rosuvastatin Hepatic Uptake: Function, Expression, and Pharmacogenetics

Inhibitors of the immunoproteasome: current status and future directions

Strategies to improve the prediction accuracy of hepatic intrinsic clearance of three antidiabetic drugs: Application of the extended clearance concept and consideration of the effect of albumin on CYP2C metabolism and OATP1B-mediated hepatic uptake

Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter–Mediated Interactions Between Metformin and Cimetidine

Transporters and renal drug elimination

Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug‐Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects

Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice

Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction

A Cancer-Specific Variant of the SLCO1B3 Gene Encodes a Novel Human Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Localized Mainly in the Cytoplasm of Colon and Pancreatic Cancer Cells

Morpholino-mediated increase in soluble Flt-1 expression results in decreased ocular and tumor neovascularization

Polymer micelle formulation for the proteasome inhibitor drug carfilzomib: Anticancer efficacy and pharmacokinetic studies in mice

The N-terminal region of organic anion transporting polypeptide 1B3 (OATP1B3) plays an essential role in regulating its plasma membrane trafficking

Semi-quantitative parameter analysis of DCE-MRI revisited: monte-carlo simulation, clinical comparisons, and clinical validation of measurement errors in patients with type 2 neurofibromatosis

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