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Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs

Scientific reports, 2020-10, Vol.10 (1), p.16569-11, Article 16569

2020

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NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells-A Potential Target for Adjuvant Radiotherapy

Cancers, 2019-04, Vol.11 (4), p.503

2019

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Coupling of a viral K + -channel with a glutamate-binding-domain highlights the modular design of ionotropic glutamate-receptors

Communications biology, 2019-02, Vol.2 (1), p.75, Article 75

2019

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Analysis of M4 Transmembrane Segments in NMDA Receptor Function: A Negative Allosteric Modulatory Site at the GluN1 M4 is Determining the Efficiency of Neurosteroid Modulation

Frontiers in pharmacology, 2021-10, Vol.12, p.769046-769046

2021

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NMDA Receptor Signaling Mediates cFos Expression via Top2β-Induced DSBs in Glioblastoma Cells

Cancers, 2019-03, Vol.11 (3), p.306

2019

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Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses?

Trends in Pharmacological Sciences, 2002-11, Vol.23 (11), p.519-527

2002

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Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice

The EMBO journal, 2007-09, Vol.26 (17), p.3888-3899

2007

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Deletion of the Mouse Glycine Transporter 2 Results in a Hyperekplexia Phenotype and Postnatal Lethality

Neuron (Cambridge, Mass.), 2003-11, Vol.40 (4), p.797-806

2003

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Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist-binding site

Journal of neurochemistry, 2012-07, Vol.122 (1), p.38-47

2012

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Evidence for a Tetrameric Structure of Recombinant NMDA Receptors

The Journal of neuroscience, 1998-04, Vol.18 (8), p.2954-2961

1998

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An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors

Nature structural & molecular biology, 2010-01, Vol.17 (1), p.90

2010

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The N-Terminal Domains of both NR1 and NR2 Subunits Determine Allosteric Zn2+ Inhibition and Glycine Affinity of N-Methyl-d-aspartate Receptors

Molecular pharmacology, 2007-12, Vol.72 (6), p.1535-1544

2007

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Glycine receptors: recent insights into their structural organization and functional diversity

Journal of neurochemistry, 2006-06, Vol.97 (6), p.1600-1610

2006

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Formation of NR1/NR2 and NR1/NR3 Heterodimers Constitutes the Initial Step in N-Methyl-D-aspartate Receptor Assembly

The Journal of biological chemistry, 2008-01, Vol.283 (1), p.37-46

2008

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Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels

Scientific reports, 2015-02, Vol.5 (1), p.8558-8558, Article 8558

2015

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Positive Modulatory Interactions of NMDA Receptor GluN1/2B Ligand Binding Domains Attenuate Antagonists Activity

Frontiers in pharmacology, 2017-05, Vol.8, p.229-229

2017

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Molecular Determinants of Agonist Discrimination by NMDA Receptor Subunits: Analysis of the Glutamate Binding Site on the NR2B Subunit

Neuron (Cambridge, Mass.), 1997-03, Vol.18 (3), p.493-503

1997

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Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics

International journal for parasitology -- drugs and drug resistance, 2014-12, Vol.4 (3), p.244-255

2014

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Functional Coupling of Bacterial Binding Protein with the Channel Pore of an Ionotropic Glutamate Receptor

Biophysical journal, 2017-02, Vol.112 (3), p.419a-419a

2017

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Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn²⁺ and NR1 antagonist

Proceedings of the National Academy of Sciences - PNAS, 2008-08, Vol.105 (34), p.12563-12568

2008

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Opposing effects of the anesthetic propofol at pentameric ligand-gated ion channels mediated by a common site

The Journal of neuroscience, 2014-02, Vol.34 (6), p.2155-2159

2014

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Disruption of Interdomain Interactions in the Glutamate Binding Pocket Affects Differentially Agonist Affinity and Efficacy of N-methyl-d-aspartate Receptor Activation

The Journal of biological chemistry, 2007-01, Vol.282 (3), p.1863-1872

2007

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Kinetic and mutational analysis of Zn2+ modulation of recombinant human inhibitory glycine receptors

The Journal of physiology, 2000-01, Vol.522 (2), p.215-230

2000

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ATP Inhibits NMDA Receptors after Heterologous Expression and in Cultured Hippocampal Neurons and Attenuates NMDA-Mediated Neurotoxicity

The Journal of neuroscience, 2003-06, Vol.23 (12), p.4996-5003

2003

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Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs

Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes

NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells-A Potential Target for Adjuvant Radiotherapy

Coupling of a viral K + -channel with a glutamate-binding-domain highlights the modular design of ionotropic glutamate-receptors

Analysis of M4 Transmembrane Segments in NMDA Receptor Function: A Negative Allosteric Modulatory Site at the GluN1 M4 is Determining the Efficiency of Neurosteroid Modulation

NMDA Receptor Signaling Mediates cFos Expression via Top2β-Induced DSBs in Glioblastoma Cells

Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses?

Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice

Deletion of the Mouse Glycine Transporter 2 Results in a Hyperekplexia Phenotype and Postnatal Lethality

Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist-binding site

Evidence for a Tetrameric Structure of Recombinant NMDA Receptors

An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors

The N-Terminal Domains of both NR1 and NR2 Subunits Determine Allosteric Zn2+ Inhibition and Glycine Affinity of N-Methyl-d-aspartate Receptors

Glycine receptors: recent insights into their structural organization and functional diversity

Formation of NR1/NR2 and NR1/NR3 Heterodimers Constitutes the Initial Step in N-Methyl-D-aspartate Receptor Assembly

Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels

Positive Modulatory Interactions of NMDA Receptor GluN1/2B Ligand Binding Domains Attenuate Antagonists Activity

Molecular Determinants of Agonist Discrimination by NMDA Receptor Subunits: Analysis of the Glutamate Binding Site on the NR2B Subunit

Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics

Functional Coupling of Bacterial Binding Protein with the Channel Pore of an Ionotropic Glutamate Receptor

Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn²⁺ and NR1 antagonist

Opposing effects of the anesthetic propofol at pentameric ligand-gated ion channels mediated by a common site

Disruption of Interdomain Interactions in the Glutamate Binding Pocket Affects Differentially Agonist Affinity and Efficacy of N-methyl-d-aspartate Receptor Activation

Kinetic and mutational analysis of Zn2+ modulation of recombinant human inhibitory glycine receptors

ATP Inhibits NMDA Receptors after Heterologous Expression and in Cultured Hippocampal Neurons and Attenuates NMDA-Mediated Neurotoxicity

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