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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-( N, N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (8), p.2179-2185

2009

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Identification of Orally Active, Potent, and Selective 4-Piperazinylquinazolines as Antagonists of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase Family

Journal of medicinal chemistry, 2002-08, Vol.45 (17), p.3772-3793

2002

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ABSENCE OF QTC PROLONGATION WITH BETRIXABAN: A RANDOMIZED, DOUBLE-BLIND, PLACEBO- AND POSITIVE-CONTROLLED THOROUGH ECG STUDY

Journal of the American College of Cardiology, 2013-03, Vol.61 (10), p.E271-E271

2013

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Absence of QTc prolongation with betrixaban: a randomized, double-blind, placebo- and positive-controlled thorough ECG study

Expert opinion on pharmacotherapy, 2013-01, Vol.14 (1), p.5-13

2013

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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 3: Design, synthesis and sar of orally bioavailable benzamidine-P4 inhibitors

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1229-1234

2004

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Discovery of Novel 2,8-Diazaspiro[4.5]decanes as Orally Active Glycoprotein IIb-IIIa Antagonists

Journal of medicinal chemistry, 2004-04, Vol.47 (8), p.2037-2061

2004

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Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (4), p.983-987

2004

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Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (4), p.989-993

2004

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N, N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2073-2078

2004

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Metabolism and Disposition of Betrixaban and Its Lack of Interaction with Major CYP Enzymes

Blood, 2012-11, Vol.120 (21), p.2266-2266

2012

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1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1229-1234

2004

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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido )-5-metho xybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (8), p.2179-2185

2009

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Affinity of ligands for apoaspartate aminotransferase

Lambing, Joseph L

1990

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Buffers for the reconstitution of aspartate aminotransferase

Biochemical and biophysical research communications, 1988-03, Vol.151 (2), p.693-700

1988

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Impact of HIV on liver fibrosis in men with hepatitis C infection and haemophilia

Haemophilia : the official journal of the World Federation of Hemophilia, 2011-01, Vol.17 (1), p.103-111

2011

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Ring-chain tautomerism of oxazolidines

Tetrahedron letters, 1970, Vol.11 (4), p.299-302

1970

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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-( N, N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

Identification of Orally Active, Potent, and Selective 4-Piperazinylquinazolines as Antagonists of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase Family

ABSENCE OF QTC PROLONGATION WITH BETRIXABAN: A RANDOMIZED, DOUBLE-BLIND, PLACEBO- AND POSITIVE-CONTROLLED THOROUGH ECG STUDY

Absence of QTc prolongation with betrixaban: a randomized, double-blind, placebo- and positive-controlled thorough ECG study

1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 3: Design, synthesis and sar of orally bioavailable benzamidine-P4 inhibitors

Discovery of Novel 2,8-Diazaspiro[4.5]decanes as Orally Active Glycoprotein IIb-IIIa Antagonists

Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs

Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity

N, N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors

Metabolism and Disposition of Betrixaban and Its Lack of Interaction with Major CYP Enzymes

1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors

Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido )-5-metho xybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

Affinity of ligands for apoaspartate aminotransferase

Buffers for the reconstitution of aspartate aminotransferase

Impact of HIV on liver fibrosis in men with hepatitis C infection and haemophilia

Ring-chain tautomerism of oxazolidines

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