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Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function

PloS one, 2020-12, Vol.15 (12), p.e0243145-e0243145

2020

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Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING

ACS medicinal chemistry letters, 2019-01, Vol.10 (1), p.92-97

2019

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Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa

Proceedings of the National Academy of Sciences - PNAS, 2010-12, Vol.107 (51), p.22002-22007

2010

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Clinically Relevant Gram-Negative Resistance Mechanisms Have No Effect on the Efficacy of MC-1, a Novel Siderophore-Conjugated Monocarbam

Antimicrobial Agents and Chemotherapy, 2012-12, Vol.56 (12), p.6334-6342

2012

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An orally available non-nucleotide STING agonist with antitumor activity

Science (American Association for the Advancement of Science), 2020-08, Vol.369 (6506)

2020

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Early Insights into the Interactions of Different β-Lactam Antibiotics and β-Lactamase Inhibitors against Soluble Forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3

Antimicrobial Agents and Chemotherapy, 2012-11, Vol.56 (11), p.5687-5692

2012

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Selenium in Thioredoxin Reductase: A Mechanistic Perspective

Biochemistry (Easton), 2008-12, Vol.47 (48), p.12810-12821

2008

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Multiple Synthetic Routes to the Mini-Protein Omomyc and Coiled-Coil Domain Truncations

Journal of organic chemistry, 2020-02, Vol.85 (3), p.1466-1475

2020

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Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5)

ACS medicinal chemistry letters, 2020-09, Vol.11 (9), p.1688-1693

2020

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Identification of Potent Reverse Indazole Inhibitors for HPK1

ACS medicinal chemistry letters, 2021-03, Vol.12 (3), p.459-466

2021

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Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds

ACS medicinal chemistry letters, 2021-04, Vol.12 (4), p.653-661

2021

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Distinctive Attributes of β-Lactam Target Proteins in Acinetobacter baumannii Relevant to Development of New Antibiotics

Journal of the American Chemical Society, 2011-12, Vol.133 (50), p.20536-20545

2011

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Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors

SLAS discovery, 2021-01, Vol.26 (1), p.88-99

2021

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Characterization of mitochondrial thioredoxin reductase from C. elegans

Biochemical and biophysical research communications, 2006-08, Vol.346 (3), p.629-636

2006

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Investigation of the C-Terminal Redox Center of High-Mr Thioredoxin Reductase by Protein Engineering and Semisynthesis

Biochemistry (Easton), 2007-08, Vol.46 (33), p.9472-9483

2007

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Investigation of the C-Terminal Redox Center of High-M r Thioredoxin Reductase by Protein Engineering and Semisynthesis

Biochemistry (Easton), 2007-08, Vol.46 (33), p.9472-9483

2007

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Synthesis of peptide substrates for mammalian thioredoxin reductase

Journal of peptide science, 2008-05, Vol.14 (5), p.637-647

2008

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Early Insights into the Interactions of Different β-Lactam Antibiotics and β-Lactamase Inhibitors against Soluble Forms of Acinetobacter baumannii PBPla and Acinetobacter sp. PBP3

Antimicrobial agents and chemotherapy, 2012, Vol.56 (11), p.5687-5692

2012

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Risk of Late-Onset Breast Cancer in Genetically Predisposed Women

Journal of clinical oncology, 2021-11, Vol.39 (31), p.3430-3440

2021

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Laccases Direct Lignification in the Discrete Secondary Cell Wall Domains of Protoxylem

Plant physiology (Bethesda), 2014-10, Vol.166 (2), p.798-807

2014

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Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function

Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING

Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa

Clinically Relevant Gram-Negative Resistance Mechanisms Have No Effect on the Efficacy of MC-1, a Novel Siderophore-Conjugated Monocarbam

An orally available non-nucleotide STING agonist with antitumor activity

Early Insights into the Interactions of Different β-Lactam Antibiotics and β-Lactamase Inhibitors against Soluble Forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3

Selenium in Thioredoxin Reductase: A Mechanistic Perspective

Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer

Multiple Synthetic Routes to the Mini-Protein Omomyc and Coiled-Coil Domain Truncations

The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer

Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5)

Identification of Potent Reverse Indazole Inhibitors for HPK1

Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds

Distinctive Attributes of β-Lactam Target Proteins in Acinetobacter baumannii Relevant to Development of New Antibiotics

Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors

Characterization of mitochondrial thioredoxin reductase from C. elegans

Investigation of the C-Terminal Redox Center of High-Mr Thioredoxin Reductase by Protein Engineering and Semisynthesis

Investigation of the C-Terminal Redox Center of High-M r Thioredoxin Reductase by Protein Engineering and Semisynthesis

Synthesis of peptide substrates for mammalian thioredoxin reductase

Early Insights into the Interactions of Different β-Lactam Antibiotics and β-Lactamase Inhibitors against Soluble Forms of Acinetobacter baumannii PBPla and Acinetobacter sp. PBP3

Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial

Risk of Late-Onset Breast Cancer in Genetically Predisposed Women

Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis

Laccases Direct Lignification in the Discrete Secondary Cell Wall Domains of Protoxylem

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