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Neoclassic drug discovery: the case for lead generation using phenotypic and functional approaches

Journal of biomolecular screening, 2013-12, Vol.18 (10), p.1143-1155

2013

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Consideration of the cellular microenvironment: Physiologically relevant co-culture systems in drug discovery

Advanced drug delivery reviews, 2014-04, Vol.69-70, p.190-204

2014

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Phenotypic chemical biology for predicting safety and efficacy

Drug discovery today. Technologies, 2017-03, Vol.23, p.53-60

Berg, Ellen L.

2017

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The future of phenotypic drug discovery

Cell chemical biology, 2021-03, Vol.28 (3), p.424-430

Berg, Ellen L.

2021

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Human Cell-Based in vitro Phenotypic Profiling for Drug Safety-Related Attrition

Frontiers in big data, 2019-12, Vol.2, p.47-47

Berg, Ellen L

2019

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Building predictive models for mechanism-of-action classification from phenotypic assay data sets

Journal of biomolecular screening, 2013-12, Vol.18 (10), p.1260-1269

2013

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Systems biology in drug discovery and development

Drug discovery today, 2014-02, Vol.19 (2), p.113-125

Berg, Ellen L.

2014

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Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects

International journal of molecular sciences, 2015-01, Vol.16 (1), p.1008-1029

2015

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Regulation of IL-17A production is distinct from IL-17F in a primary human cell co-culture model of T cell-mediated B cell activation

PloS one, 2013-03, Vol.8 (3), p.e58966-e58966

2013

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Use of a rapid human primary cell-based disease screening model, to compare next generation products to combustible cigarettes

Current research in toxicology, 2021-01, Vol.2, p.309-321

2021

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The activities of drug inactive ingredients on biological targets

Science (American Association for the Advancement of Science), 2020-07, Vol.369 (6502), p.403-413

2020

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Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

Nature biotechnology, 2014-06, Vol.32 (6), p.583-591

2014

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A Direct Comparison of Selectin-Mediated Transient, Adhesive Events Using High Temporal Resolution

Biophysical journal, 1999-12, Vol.77 (6), p.3371-3383

1999

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Characterization of compound mechanisms and secondary activities by BioMAP analysis

Journal of pharmacological and toxicological methods, 2006-01, Vol.53 (1), p.67-74

2006

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Systems biology in drug discovery

Nature biotechnology, 2004-10, Vol.22 (10), p.1253-1259

2004

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Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators

Cell chemical biology, 2017-07, Vol.24 (7), p.858-869.e5

2017

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An integrative biology approach for analysis of drug action in models of human vascular inflammation

The FASEB journal, 2004-08, Vol.18 (11), p.1279-1281

2004

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Phenotypic profiling for understanding mechanisms of cardiovascular adverse reactions

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells

ALTEX, 2023-01, Vol.40 (2), p.248–270-248–270

2023

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Method for Analyzing Signaling Networks in Complex Cellular Systems

Proceedings of the National Academy of Sciences - PNAS, 2004-02, Vol.101 (5), p.1223-1228

2004

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Advancing nonclinical innovation and safety in pharmaceutical testing

Drug discovery today, 2019-02, Vol.24 (2), p.624-628

2019

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Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system

Toxicology in vitro, 2019-02, Vol.54, p.41-57

2019

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Profiling Bioactivity of the ToxCast Chemical Library Using BioMAP Primary Human Cell Systems

Journal of biomolecular screening, 2009-10, Vol.14 (9), p.1054-1066

2009

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Chemical target and pathway toxicity mechanisms defined in primary human cell systems

Journal of pharmacological and toxicological methods, 2010-01, Vol.61 (1), p.3-15

2010

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Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models

Assay and drug development technologies, 2004-08, Vol.2 (4), p.431-442

2004

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Neoclassic drug discovery: the case for lead generation using phenotypic and functional approaches

Consideration of the cellular microenvironment: Physiologically relevant co-culture systems in drug discovery

Phenotypic chemical biology for predicting safety and efficacy

The future of phenotypic drug discovery

Human Cell-Based in vitro Phenotypic Profiling for Drug Safety-Related Attrition

Building predictive models for mechanism-of-action classification from phenotypic assay data sets

Systems biology in drug discovery and development

Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects

Regulation of IL-17A production is distinct from IL-17F in a primary human cell co-culture model of T cell-mediated B cell activation

Use of a rapid human primary cell-based disease screening model, to compare next generation products to combustible cigarettes

The activities of drug inactive ingredients on biological targets

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

A Direct Comparison of Selectin-Mediated Transient, Adhesive Events Using High Temporal Resolution

Characterization of compound mechanisms and secondary activities by BioMAP analysis

Systems biology in drug discovery

Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators

An integrative biology approach for analysis of drug action in models of human vascular inflammation

Phenotypic profiling for understanding mechanisms of cardiovascular adverse reactions

Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells

Method for Analyzing Signaling Networks in Complex Cellular Systems

Advancing nonclinical innovation and safety in pharmaceutical testing

Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system

Profiling Bioactivity of the ToxCast Chemical Library Using BioMAP Primary Human Cell Systems

Chemical target and pathway toxicity mechanisms defined in primary human cell systems

Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models

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