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AAV Vector Immunogenicity in Humans: A Long Journey to Successful Gene Transfer

Molecular therapy, 2020-03, Vol.28 (3), p.723-746

2020

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Long-Term Follow-Up of the First in Human Intravascular Delivery of AAV for Gene Transfer: AAV2-hFIX16 for Severe Hemophilia B

Molecular therapy, 2020-09, Vol.28 (9), p.2073-2082

2020

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Exposure to wild-type AAV drives distinct capsid immunity profiles in humans

The Journal of clinical investigation, 2018-12, Vol.128 (12), p.5267-5279

2018

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Pre-existing humoral immunity and complement pathway contribute to immunogenicity of adeno-associated virus (AAV) vector in human blood

Frontiers in immunology, 2022-09, Vol.13, p.999021-999021

2022

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Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation

Current stem cell reports, 2016-06, Vol.6 (6), p.970-984

2016

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The PI3K/AKT Signaling Pathway Controls the Quiescence of the Low‐Rhodamine123‐Retention Cell Compartment Enriched for Melanoma Stem Cell Activity

Stem cells (Dayton, Ohio), 2013-04, Vol.31 (4), p.641-651

2013

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In Vitro Expansion of Anti-viral T Cells from Cord Blood by Accelerated Co-cultured Dendritic Cells

Molecular therapy. Methods & clinical development, 2019-06, Vol.13, p.112-120

2019

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Expression of CD34 in hematopoietic cancer cell lines reflects tightly regulated stem/progenitor-like state

Journal of cellular biochemistry, 2011-05, Vol.112 (5), p.1277-1285

2011

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A subpopulation of malignant CD34+ CD138+ B7-H1+ plasma cells is present in multiple myeloma patients

Experimental hematology, 2010-02, Vol.38 (2), p.124-131.e4

2010

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Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A

The New England journal of medicine, 2021-11, Vol.385 (21), p.1961-1973

2021

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Tocilizumab As a Novel Immunomodulatory Regimen for Hemophilia Gene Therapy

Blood, 2021-11, Vol.138 (Supplement 1), p.1853-1853

2021

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The Effect of CpG Sequences on Capsid-Specific CD8+ T Cell Responses to AAV Vector Gene Transfer

Molecular therapy, 2020-03, Vol.28 (3), p.771-783

2020

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Age‐related changes in human hematopoietic stem/progenitor cells

Aging cell, 2011-06, Vol.10 (3), p.542-546

2011

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In acute myeloid leukemia, B7-H1 (PD-L1) protection of blasts from cytotoxic T cells is induced by TLR ligands and interferon-gamma and can be reversed using MEK inhibitors

Cancer Immunology, Immunotherapy, 2010-12, Vol.59 (12), p.1839-1849

2010

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Investigating the caffeine effects in the yeast Saccharomyces cerevisiae brings new insights into the connection between TOR, PKC and Ras/cAMP signalling pathways

Molecular microbiology, 2006-09, Vol.61 (5), p.1147-1166

2006

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Exposure to wild-type AAV drives distinct capsid immunity profiles in humans

The Journal of clinical investigation, 2018-10, Vol.128 (12), p.5267-5279

2018

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Interim Analysis of Immunogenicity to the Vector Capsid and Transgene-Expressed Human FVIII in a Phase-1/2 Clinical Study of Bmn 270, an AAV5-Mediated Gene Therapy for Hemophilia a

Blood, 2017-12, Vol.130, p.4611-4611

2017

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isoprenoid pathway and transcriptional response to its inhibitors in the yeast Saccharomyces cerevisiae

FEMS yeast research, 2010-02, Vol.10 (1), p.14-27

2010

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Long-term exposure to Myozyme results in a decrease of anti-drug antibodies in late-onset Pompe disease patients

Scientific reports, 2016-11, Vol.6 (1), p.36182-36182, Article 36182

2016

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AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway

Blood, 2011-08, Vol.118 (7), p.1784-1796

2011

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Age-related changes in human hematopoietic stem/progenitor cells: Aging of human HSC

Aging cell, 2011-06, Vol.10 (3), p.542-546

2011

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YTA7 gene is involved in the regulation of the isoprenoid pathway in the yeast Saccharomyces cerevisiae

FEMS yeast research, 2009-05, Vol.9 (3), p.381-390

2009

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AAV Vector-Based Gene Therapy, Progress and Current Challenges

Safety and Efficacy of Gene-Based Therapeutics for Inherited Disorders, 2017, p.77-112

2017

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AAV Vector Immunogenicity in Humans: A Long Journey to Successful Gene Transfer

Long-Term Follow-Up of the First in Human Intravascular Delivery of AAV for Gene Transfer: AAV2-hFIX16 for Severe Hemophilia B

Exposure to wild-type AAV drives distinct capsid immunity profiles in humans

Pre-existing humoral immunity and complement pathway contribute to immunogenicity of adeno-associated virus (AAV) vector in human blood

Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation

The PI3K/AKT Signaling Pathway Controls the Quiescence of the Low‐Rhodamine123‐Retention Cell Compartment Enriched for Melanoma Stem Cell Activity

In Vitro Expansion of Anti-viral T Cells from Cord Blood by Accelerated Co-cultured Dendritic Cells

Expression of CD34 in hematopoietic cancer cell lines reflects tightly regulated stem/progenitor-like state

A subpopulation of malignant CD34+ CD138+ B7-H1+ plasma cells is present in multiple myeloma patients

Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A

Tocilizumab As a Novel Immunomodulatory Regimen for Hemophilia Gene Therapy

The Effect of CpG Sequences on Capsid-Specific CD8+ T Cell Responses to AAV Vector Gene Transfer

Age‐related changes in human hematopoietic stem/progenitor cells

In acute myeloid leukemia, B7-H1 (PD-L1) protection of blasts from cytotoxic T cells is induced by TLR ligands and interferon-gamma and can be reversed using MEK inhibitors

Investigating the caffeine effects in the yeast Saccharomyces cerevisiae brings new insights into the connection between TOR, PKC and Ras/cAMP signalling pathways

Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

Exposure to wild-type AAV drives distinct capsid immunity profiles in humans

Interim Analysis of Immunogenicity to the Vector Capsid and Transgene-Expressed Human FVIII in a Phase-1/2 Clinical Study of Bmn 270, an AAV5-Mediated Gene Therapy for Hemophilia a

Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness

isoprenoid pathway and transcriptional response to its inhibitors in the yeast Saccharomyces cerevisiae

Long-term exposure to Myozyme results in a decrease of anti-drug antibodies in late-onset Pompe disease patients

AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway

Age-related changes in human hematopoietic stem/progenitor cells: Aging of human HSC

YTA7 gene is involved in the regulation of the isoprenoid pathway in the yeast Saccharomyces cerevisiae

AAV Vector-Based Gene Therapy, Progress and Current Challenges

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