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Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides

Scientific reports, 2016-07, Vol.6 (1), p.30377, Article 30377

2016

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Sulfonamide-Bridged Nucleic Acid: Synthesis, High RNA Selective Hybridization, and High Nuclease Resistance

Organic letters, 2014-11, Vol.16 (21), p.5640-5643

2014

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RNA Reduction and Hepatotoxic Potential Caused by Non-Gapmer Antisense Oligonucleotides

Nucleic acid therapeutics, 2019-02, Vol.29 (1), p.44-50

2019

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S-540956, a CpG Oligonucleotide Annealed to a Complementary Strand With an Amphiphilic Chain Unit, Acts as a Potent Cancer Vaccine Adjuvant by Targeting Draining Lymph Nodes

Frontiers in immunology, 2021-12, Vol.12, p.803090-803090

2021

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Gene Silencing Activity and Hepatic Accumulation of Antisense Oligonucleotides Bearing Cholesterol-Conjugated Thiono Triester at the Gap Region

Nucleic acid therapeutics, 2017-08, Vol.27 (4), p.232-237

2017

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Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency

Journal of organic chemistry, 2017-01, Vol.82 (1), p.12-24

2017

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Effect of the potent and selective DP1 receptor antagonist, asapiprant (S-555739), in animal models of allergic rhinitis and allergic asthma

European journal of pharmacology, 2015-10, Vol.765, p.15-23

2015

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Surface Plasmon Resonance Assay of Binding Properties of Antisense Oligonucleotides to Serum Albumins and Lipoproteins

Analytical Sciences, 2015/12/10, Vol.31(12), pp.1255-1260

2015

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Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure

Organic & biomolecular chemistry, 2016-01, Vol.14 (27), p.6531-6538

2016

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Role of Computationally Evaluated Target Specificity in the Hepatotoxicity of Gapmer Antisense Oligonucleotides

Nucleic acid therapeutics, 2018-10, Vol.28 (5), p.312-317

2018

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Abstract 1916: Lymph node targeting double stranded CpG act effective adjuvant in cancer peptide vaccine

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1916-1916

2021

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Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands Targeting Apolipoprotein B

The Journal of pharmacology and experimental therapeutics, 2016-05, Vol.357 (2), p.320-330

2016

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Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structureElectronic supplementary information (ESI) available. CCDC 1415387. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6ob01051b

2016-07

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Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant

Angewandte Chemie International Edition, 1998-04, Vol.37 (7), p.973-975

1998

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Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4923-4927

2011

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Synthesis and Evaluation of Diaryl Thiazole Derivatives that Inhibit Activation of Sterol Regulatory Element-Binding Proteins

Journal of medicinal chemistry, 2011-06, Vol.54 (13), p.4923-4927

2011

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A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP

Chemistry & biology, 2009-08, Vol.16 (8), p.882-892

2009

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Total Synthesis of Terprenin, a Novel Immunosuppressive p-Terphenyl Derivative

Journal of organic chemistry, 1998-08, Vol.63 (17), p.5831-5837

1998

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New γ-fluoromethotrexates modified in the pteridine ring: synthesis and in vitro immunosuppressive activity

European journal of medicinal chemistry, 2000-05, Vol.35 (5), p.529-534

2000

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Synthesis and Evaluation of Novel Fluorinated Methotrexate Derivatives for Application to Rheumatoid Arthritis Treatment

Journal of medicinal chemistry, 1997-09, Vol.40 (20), p.3280-3291

1997

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Role of LXRs in control of lipogenesis

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2007-10, Vol.52 (13 Suppl), p.1814

2007

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Totalsynthese von Terprenin, einem hochwirksamen Immunglobulin-E-Suppressivum

Angewandte Chemie, 1998-04, Vol.110 (7), p.1015-1017

1998

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Totalsynthese von Terprenin, einem hochwirksamen Immunglobulin‐E‐Suppressivum

Angewandte Chemie, 1998-04, Vol.110 (7), p.1015-1017

1998

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ChemInform Abstract: New γ-Fluoromethotrexates Modified in the Pteridine Ring: Synthesis and in vitro Immunosuppressive Activity

ChemInform, 2000-09, Vol.31 (39), p.no-no

2000

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Dinitrogen Fixation by Vanadium Complexes with a Triamidoamine Ligand

Inorganic chemistry, 2018-10, Vol.57 (19), p.11884-11894

2018

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Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides

Sulfonamide-Bridged Nucleic Acid: Synthesis, High RNA Selective Hybridization, and High Nuclease Resistance

RNA Reduction and Hepatotoxic Potential Caused by Non-Gapmer Antisense Oligonucleotides

S-540956, a CpG Oligonucleotide Annealed to a Complementary Strand With an Amphiphilic Chain Unit, Acts as a Potent Cancer Vaccine Adjuvant by Targeting Draining Lymph Nodes

Gene Silencing Activity and Hepatic Accumulation of Antisense Oligonucleotides Bearing Cholesterol-Conjugated Thiono Triester at the Gap Region

Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency

Effect of the potent and selective DP1 receptor antagonist, asapiprant (S-555739), in animal models of allergic rhinitis and allergic asthma

Surface Plasmon Resonance Assay of Binding Properties of Antisense Oligonucleotides to Serum Albumins and Lipoproteins

Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure

Role of Computationally Evaluated Target Specificity in the Hepatotoxicity of Gapmer Antisense Oligonucleotides

Abstract 1916: Lymph node targeting double stranded CpG act effective adjuvant in cancer peptide vaccine

Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands Targeting Apolipoprotein B

Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structureElectronic supplementary information (ESI) available. CCDC 1415387. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6ob01051b

Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant

Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins

Synthesis and Evaluation of Diaryl Thiazole Derivatives that Inhibit Activation of Sterol Regulatory Element-Binding Proteins

A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP

Total Synthesis of Terprenin, a Novel Immunosuppressive p-Terphenyl Derivative

New γ-fluoromethotrexates modified in the pteridine ring: synthesis and in vitro immunosuppressive activity

Synthesis and Evaluation of Novel Fluorinated Methotrexate Derivatives for Application to Rheumatoid Arthritis Treatment

Role of LXRs in control of lipogenesis

Totalsynthese von Terprenin, einem hochwirksamen Immunglobulin-E-Suppressivum

Totalsynthese von Terprenin, einem hochwirksamen Immunglobulin‐E‐Suppressivum

ChemInform Abstract: New γ-Fluoromethotrexates Modified in the Pteridine Ring: Synthesis and in vitro Immunosuppressive Activity

Dinitrogen Fixation by Vanadium Complexes with a Triamidoamine Ligand

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