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Development of Antisense Drugs for Dyslipidemia

Journal of Atherosclerosis and Thrombosis, 2016/09/01, Vol.23(9), pp.1011-1025

2016

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Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides

Journal of controlled release, 2016-03, Vol.226, p.57-65

2016

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Ca2+ enrichment in culture medium potentiates effect of oligonucleotides

Nucleic acids research, 2015-10, Vol.43 (19), p.e128

2015

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Synthesis, duplex-forming ability, enzymatic stability, and in vitro antisense potency of oligonucleotides including 2'-C,4'-C-ethyleneoxy-bridged thymidine derivatives

Organic & biomolecular chemistry, 2017, Vol.15 (18), p.3955-3963

2017

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Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides

Pharmaceutics, 2021-05, Vol.13 (6), p.817

2021

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Cholesterol-GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides

Nucleic acid therapeutics, 2018-02, Vol.28 (1), p.50

2018

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Programmed Instability of Ligand Conjugation Manifold for Efficient Hepatocyte Delivery of Therapeutic Oligonucleotides

Nucleic acid therapeutics, 2021-12, Vol.31 (6), p.404

2021

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Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency

Journal of organic chemistry, 2017-01, Vol.82 (1), p.12-24

2017

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Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides

Molecular therapy. Nucleic acids, 2021-12, Vol.26, p.957-969

2021

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Development of Antisense Drugs for Dyslipidemia

Journal of Atherosclerosis and Thrombosis, 2016, Vol.23 (9), p.1011-1025

2016

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Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes

Molecular therapy. Nucleic acids, 2017-12, Vol.9 (C), p.170-181

2017

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Evaluation of multiple-turnover capability of locked nucleic acid antisense oligonucleotides in cell-free RNase H-mediated antisense reaction and in mice

Nucleic acid therapeutics, 2014-08, Vol.24 (4), p.283

2014

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Locked nucleic acid antisense inhibitor targeting apolipoprotein C-III efficiently and preferentially removes triglyceride from large very low-density lipoprotein particles in murine plasma

European journal of pharmacology, 2014-01, Vol.723, p.353-359

2014

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Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure

Organic & biomolecular chemistry, 2016-01, Vol.14 (27), p.6531-6538

2016

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Superior Silencing by 2',4'-BNA^(NC)-Based Short Antisense Oligonucleotides Compared to 2',4'-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors

Journal of Nucleic Acids, 2012-01, Vol.2012, p.707323-707323

2012

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Rational design of prodrug-type apoB-targeted siRNA for nuclease resistance improvement without compromising gene silencing potency

Bioorganic & medicinal chemistry, 2024-04, Vol.104, p.117693-117693, Article 117693

2024

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Calcium-Mediated In Vitro Transfection Technique of Oligonucleotides with Broad Chemical Modification Compatibility

Methods in molecular biology (Clifton, N.J.), 2020, Vol.2176, p.141

2020

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Prodrug‐Type Phosphotriester Oligonucleotides with Linear Disulfide Promoieties Responsive to Reducing Environment

Chembiochem : a European journal of chemical biology, 2023-12, Vol.24 (24), p.e202300526-n/a

2023

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Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides

Bioorganic & medicinal chemistry, 2016-01, Vol.24 (1), p.26-32

2016

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Amido-bridged nucleic acids with small hydrophobic residues enhance hepatic tropism of antisense oligonucleotides in vivo

Organic & biomolecular chemistry, 2015-03, Vol.13 (12), p.3757-3765

2015

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Efficacy and safety of antisense drug targeting PCSK9 in non human primates

Atherosclerosis, 2017-08, Vol.263, p.e245-e245

2017

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Superior Silencing by 2′,4′-BNANC-Based Short Antisense Oligonucleotides Compared to 2′,4′-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors

Journal of nucleic acids, 2012-01, Vol.2012

2012

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Effective gene silencing activity of prodrug-type 2′-O-methyldithiomethyl siRNA compared with non-prodrug-type 2′-O-methyl siRNA

Bioorganic & medicinal chemistry letters, 2018-07, Vol.28 (12), p.2171-2174

2018

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Effect of modular conjugation strategy for N-acetylgalactosamine-targeted antisense oligonucleotides

Nucleosides, nucleotides & nucleic acids, 2020-02, Vol.39 (1-3), p.109-118

2020

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Synthesis, duplex-forming ability, enzymatic stability, and in vitro antisense potency of oligonucleotides including 2′-C,4′-C-ethyleneoxy-bridged thymidine derivativesElectronic supplementary information (ESI) available: 1H, 13C and 31P spectra of all new compounds, H-H COSY and NOESY spectra of compounds 3 and 9, MALDI-TOF mass data and HPLC charts of new oligonucleotides, representative UV melting data, and conformational analysis of (R)- and (S)-Me-EoDNAs. See DOI: 10.1039/c7ob00698e

2017-05

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Development of Antisense Drugs for Dyslipidemia

Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides

Ca2+ enrichment in culture medium potentiates effect of oligonucleotides

Synthesis, duplex-forming ability, enzymatic stability, and in vitro antisense potency of oligonucleotides including 2'-C,4'-C-ethyleneoxy-bridged thymidine derivatives

Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides

Cholesterol-GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides

Programmed Instability of Ligand Conjugation Manifold for Efficient Hepatocyte Delivery of Therapeutic Oligonucleotides

Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency

Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides

Development of Antisense Drugs for Dyslipidemia

Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes

Evaluation of multiple-turnover capability of locked nucleic acid antisense oligonucleotides in cell-free RNase H-mediated antisense reaction and in mice

Locked nucleic acid antisense inhibitor targeting apolipoprotein C-III efficiently and preferentially removes triglyceride from large very low-density lipoprotein particles in murine plasma

Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure

Superior Silencing by 2',4'-BNA^(NC)-Based Short Antisense Oligonucleotides Compared to 2',4'-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors

Rational design of prodrug-type apoB-targeted siRNA for nuclease resistance improvement without compromising gene silencing potency

Calcium-Mediated In Vitro Transfection Technique of Oligonucleotides with Broad Chemical Modification Compatibility

Prodrug‐Type Phosphotriester Oligonucleotides with Linear Disulfide Promoieties Responsive to Reducing Environment

Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides

Amido-bridged nucleic acids with small hydrophobic residues enhance hepatic tropism of antisense oligonucleotides in vivo

Efficacy and safety of antisense drug targeting PCSK9 in non human primates

Superior Silencing by 2′,4′-BNANC-Based Short Antisense Oligonucleotides Compared to 2′,4′-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors

Effective gene silencing activity of prodrug-type 2′-O-methyldithiomethyl siRNA compared with non-prodrug-type 2′-O-methyl siRNA

Effect of modular conjugation strategy for N-acetylgalactosamine-targeted antisense oligonucleotides

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