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Towards whole-body systems physiology

Molecular systems biology, 2010-09, Vol.6 (1), p.409-n/a

Kuepfer, Lars

2010

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Prospects and limitations of physiologically-based pharmacokinetic modelling for cross-species extrapolation

SVU-International journal of veterinary sciences, 2019-07, Vol.2 (2), p.45-51

Kuepfer, Lars

2019

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A workflow to build PBTK models for novel species

Archives of toxicology, 2020-11, Vol.94 (11), p.3847-3860

2020

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PBPK-based translation from preclinical species to humans for the full-size IgG therapeutic efalizumab

Frontiers in pharmacology, 2024-10, Vol.15, p.1418870

2024

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Physiologically based pharmacokinetic models for systemic disposition of protein therapeutics in rabbits

Frontiers in pharmacology, 2024-08, Vol.15, p.1427325

2024

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Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Scientific reports, 2024-03, Vol.14 (1), p.6286-6286, Article 6286

2024

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Bayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant Populations

PloS one, 2015-10, Vol.10 (10), p.e0139423-e0139423

2015

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Quantitative systems pharmacology of the eye: Tools and data for ocular QSP

CPT: pharmacometrics and systems pharmacology, 2023-03, Vol.12 (3), p.288-299

2023

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Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood

Hepatology (Baltimore, Md.), 2019-02, Vol.69 (2), p.666-683

2019

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Integrating cellular metabolism into a multiscale whole-body model

PLoS computational biology, 2012-10, Vol.8 (10), p.e1002750

2012

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A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim

Journal of pharmacokinetics and pharmacodynamics, 2018-04, Vol.45 (2), p.235-257

2018

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Metabolic functions of duplicate genes in Saccharomyces cerevisiae

Genome research, 2005-10, Vol.15 (10), p.1421-1430

2005

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Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage

Scientific reports, 2017-07, Vol.7 (1), p.6224-13, Article 6224

2017

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Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney

Archives of toxicology, 2021-06, Vol.95 (6), p.2163-2177

2021

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Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations

PloS one, 2015-07, Vol.10 (7), p.e0133653-e0133653

2015

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Computational Models for Clinical Applications in Personalized Medicine-Guidelines and Recommendations for Data Integration and Model Validation

Journal of personalized medicine, 2022-01, Vol.12 (2), p.166

2022

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Spatio-temporal simulation of first pass drug perfusion in the liver

PLoS computational biology, 2014-03, Vol.10 (3), p.e1003499

2014

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A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients

Frontiers in physiology, 2019-09, Vol.10, p.1192-1192

2019

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Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice

Frontiers in pharmacology, 2023-11, Vol.14, p.1279357-1279357

2023

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Data‐driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment

CPT: pharmacometrics and systems pharmacology, 2021-07, Vol.10 (7), p.782-793

2021

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A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations

PLoS computational biology, 2017-02, Vol.13 (2), p.e1005280-e1005280

2017

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Computational modeling and analysis of iron release from macrophages

PLoS computational biology, 2014-07, Vol.10 (7), p.e1003701-e1003701

2014

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A physiologically based model of bile acid metabolism in mice

iScience, 2023-10, Vol.26 (10), p.107922, Article 107922

2023

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Evaluation of the efficacy and safety of rivaroxaban using a computer model for blood coagulation

PloS one, 2011-04, Vol.6 (4), p.e17626

2011

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Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli

Molecular systems biology, 2007, Vol.3 (1), p.119-n/a

2007

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Towards whole-body systems physiology

Prospects and limitations of physiologically-based pharmacokinetic modelling for cross-species extrapolation

A workflow to build PBTK models for novel species

PBPK-based translation from preclinical species to humans for the full-size IgG therapeutic efalizumab

Physiologically based pharmacokinetic models for systemic disposition of protein therapeutics in rabbits

Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Bayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant Populations

Quantitative systems pharmacology of the eye: Tools and data for ocular QSP

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood

Integrating cellular metabolism into a multiscale whole-body model

A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim

Metabolic functions of duplicate genes in Saccharomyces cerevisiae

Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage

Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney

Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations

Computational Models for Clinical Applications in Personalized Medicine-Guidelines and Recommendations for Data Integration and Model Validation

Spatio-temporal simulation of first pass drug perfusion in the liver

A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients

Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice

Data‐driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment

A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations

Computational modeling and analysis of iron release from macrophages

A physiologically based model of bile acid metabolism in mice

Evaluation of the efficacy and safety of rivaroxaban using a computer model for blood coagulation

Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli

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