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UHPLC-HRMS study of anti-Alzheimer’s drug candidates: metabolism of 7-MEOTA-tryptophan hybrids hampers their passage into brain

Journal of pharmaceutical and biomedical analysis, 2019-09, Vol.174, p.134-144

2019

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P-451 - Changes of cellular respiration in patients with alzheimer's disease

European psychiatry, 2012-01, Vol.27, p.1

2012

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P.760 Effects of novel cholinesterase inhibitors on mitochondrial respiration and MAO activity - in vitro study

European neuropsychopharmacology, 2020-11, Vol.40, p.S430-S430

2020

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The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease

European journal of medicinal chemistry, 2018-04, Vol.150, p.292-306

2018

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UHPLC-HRMS study of pharmacokinetics of a novel hybrid cholinesterase inhibitor K1234: A comparison between in silico, in vitro and in vivo data

Journal of pharmaceutical and biomedical analysis, 2022-09, Vol.219, p.114898-114898, Article 114898

2022

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UHPLC-Orbitrap study of the first phase tacrine in vitro metabolites and related Alzheimer's drug candidates using human liver microsomes

Journal of pharmaceutical and biomedical analysis, 2023-02, Vol.224, p.115154, Article 115154

2023

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P.5.a.002 Therapeutic effect of novel 7-methoxytacrine-donepezil like hybrids on cognitive deficit in rats – a potentiality for Alzheimer's disease treatment

European neuropsychopharmacology, 2015-09, Vol.25, p.S577-S578

2015

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P.5.a.001 The effect of novel tacrine-related cholinesterase inhibitors on cognitive deficit induced by 3-quinuclidinyl benzilate in rats

European neuropsychopharmacology, 2015-09, Vol.25, p.S577-S577

2015

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Tetroxime: reactivation potency - in vitro and in silico study

RSC advances, 2017-01, Vol.7 (12), p.741-745

2017

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A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication

Toxicology research (Cambridge), 2016-07, Vol.5 (4), p.1012-1016

2016

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Huprines - an insight into the synthesis and biological properties

Russian chemical reviews, 2020-10, Vol.89 (10), p.999-1039

2020

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P.8.b.001 Interaction of acetylcholinesterase reactivators with albumin

European neuropsychopharmacology, 2012-10, Vol.22, p.S439-S440

2012

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7-methoxyderivative of tacrine is a potent open channel blocker of NMDA receptors

Journal of the neurological sciences, 2017-10, Vol.381, p.490-491

2017

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Tacrine First-Phase Biotransformation and Associated Hepatotoxicity: A Possible Way to Avoid Quinone Methide Formation

ACS chemical biology, 2023-09, Vol.18 (9), p.1993-2002

2023

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Non-peptide orexin 2 receptor modulators as promising way to treatment of narcolepsy/insomnia

Journal of the neurological sciences, 2019-10, Vol.405, p.98-98

2019

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P.525 Tacrine derivatives as potent inhibitors of N-methyl-D-aspartate receptors with neuroprotective activity

European neuropsychopharmacology, 2019-12, Vol.29, p.S370-S371

2019

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1-Benzyl-4-methylpiperidinyl moiety in donepezil: The priority ticket across the blood-brain-barrier in rats

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018-08, Vol.1092, p.350-358

2018

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Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine

Science advances, 2021-09, Vol.7 (36), p.eabi6856-eabi6856

2021

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Tacrine - tryptophan derivatives – novel agents against the Alzheimer’s disease

Journal of the neurological sciences, 2017-10, Vol.381, p.1017-1018

2017

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In vitro effects of newly developed cholinesterase inhibitors and ABAD modulators on mitochondrial respiration

European neuropsychopharmacology, 2017-10, Vol.27, p.S1022

2017

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P.5.a.001 - In vitro effects of newly developed cholinesterase inhibitors and ABAD modulators on mitochondrial respiration

European neuropsychopharmacology, 2017-10, Vol.27, p.S1022-S1022

2017

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In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain

Neuro-endocrinology letters, 2011, Vol.32 (3), p.259-263

2011

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A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxicationElectronic supplementary information (ESI) available: Experimental procedures and characterization of all compounds. See DOI: 10.1039/c6tx00130k

2016-06

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A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication† †Electronic supplementary information (ESI) available: Experimental procedures and characterization of all compounds. See DOI: 10.1039/c6tx00130k

Toxicology research (Cambridge), 2016-05, Vol.5 (4), p.1012-1016

2016

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7-phenoxytacrine and its derivative potently inhibits the GluN1/GluN2B subtype of NMDA receptor via an ifenprodil-binding site

Neuroscience Applied, 2022, Vol.1, p.100399, Article 100399

2022

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Blood-Brain Barrier
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UHPLC-HRMS study of anti-Alzheimer’s drug candidates: metabolism of 7-MEOTA-tryptophan hybrids hampers their passage into brain

P-451 - Changes of cellular respiration in patients with alzheimer's disease

P.760 Effects of novel cholinesterase inhibitors on mitochondrial respiration and MAO activity - in vitro study

The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease

UHPLC-HRMS study of pharmacokinetics of a novel hybrid cholinesterase inhibitor K1234: A comparison between in silico, in vitro and in vivo data

UHPLC-Orbitrap study of the first phase tacrine in vitro metabolites and related Alzheimer's drug candidates using human liver microsomes

P.5.a.002 Therapeutic effect of novel 7-methoxytacrine-donepezil like hybrids on cognitive deficit in rats – a potentiality for Alzheimer's disease treatment

P.5.a.001 The effect of novel tacrine-related cholinesterase inhibitors on cognitive deficit induced by 3-quinuclidinyl benzilate in rats

Tetroxime: reactivation potency - in vitro and in silico study

A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication

Huprines - an insight into the synthesis and biological properties

P.8.b.001 Interaction of acetylcholinesterase reactivators with albumin

7-methoxyderivative of tacrine is a potent open channel blocker of NMDA receptors

Tacrine First-Phase Biotransformation and Associated Hepatotoxicity: A Possible Way to Avoid Quinone Methide Formation

Non-peptide orexin 2 receptor modulators as promising way to treatment of narcolepsy/insomnia

P.525 Tacrine derivatives as potent inhibitors of N-methyl-D-aspartate receptors with neuroprotective activity

1-Benzyl-4-methylpiperidinyl moiety in donepezil: The priority ticket across the blood-brain-barrier in rats

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine

Tacrine - tryptophan derivatives – novel agents against the Alzheimer’s disease

In vitro effects of newly developed cholinesterase inhibitors and ABAD modulators on mitochondrial respiration

P.5.a.001 - In vitro effects of newly developed cholinesterase inhibitors and ABAD modulators on mitochondrial respiration

In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain

A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxicationElectronic supplementary information (ESI) available: Experimental procedures and characterization of all compounds. See DOI: 10.1039/c6tx00130k

A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication† †Electronic supplementary information (ESI) available: Experimental procedures and characterization of all compounds. See DOI: 10.1039/c6tx00130k

7-phenoxytacrine and its derivative potently inhibits the GluN1/GluN2B subtype of NMDA receptor via an ifenprodil-binding site

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