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Thrombin promotes diet-induced obesity through fibrin-driven inflammation

The Journal of clinical investigation, 2017-08, Vol.127 (8), p.3152-3166

2017

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Intrahepatic fibrin(ogen) deposition drives liver regeneration after partial hepatectomy in mice and humans

Blood, 2019-03, Vol.133 (11), p.1245-1256

2019

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A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice

Blood, 2020-05, Vol.135 (19), p.1704-1717

2020

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Microphysiological systems in early stage drug development: Perspectives on current applications and future impact

The Journal of Toxicological Sciences, 2021, Vol.46(3), pp.99-114

2021

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Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury

Journal of hepatology, 2016-01, Vol.64 (1), p.53-59

2016

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Hepatocyte tissue factor activates the coagulation cascade in mice

Blood, 2013-03, Vol.121 (10), p.1868-1874

2013

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Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium

Toxicological sciences, 2011-09, Vol.123 (1), p.58-70

2011

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The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury

The Journal of pharmacology and experimental therapeutics, 2014-06, Vol.349 (3), p.383

2014

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Role of the blood coagulation cascade in hepatic fibrosis

American journal of physiology: Gastrointestinal and liver physiology, 2018-08, Vol.315 (2), p.G171-G176

2018

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Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water

Toxicology and applied pharmacology, 2012-02, Vol.259 (1), p.13-26

2012

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Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice

PloS one, 2015-09, Vol.10 (9), p.e0139270

2015

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Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice

Toxicological sciences, 2013-10, Vol.135 (2), p.465-475

2013

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Automated Dose-Response Analysis and Comparative Toxicogenomic Evaluation of the Hepatic Effects Elicited by TCDD, TCDF, and PCB126 in C57BL/6 Mice

Toxicological sciences, 2010-11, Vol.118 (1), p.286-297

2010

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PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: Comparative toxicogenomic effects of dioxin and non-dioxin-like ligands

Toxicology and applied pharmacology, 2010-03, Vol.243 (3), p.359-371

2010

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Cross‐linking by tissue transglutaminase‐2 alters fibrinogen‐directed macrophage proinflammatory activity

Journal of thrombosis and haemostasis, 2022-05, Vol.20 (5), p.1182-1192

2022

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Role of Fibrin(ogen) in Progression of Liver Disease: Guilt by Association?

Seminars in thrombosis and hemostasis, 2016-06, Vol.42 (4), p.397

2016

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Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of Mmp12

Journal of hepatology, 2017-04, Vol.66 (4), p.787-797

2017

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The Current Status and Use of Microphysiological Systems by the Pharmaceutical Industry: The International Consortium for Innovation and Quality Microphysiological Systems Affiliate Survey and Commentary

Drug metabolism and disposition, 2024-03, Vol.52 (3), p.198

2024

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Von Willebrand factor exerts hepatoprotective effects in acute but not chronic cholestatic liver injury in mice

Toxicology (Amsterdam), 2021-11, Vol.463, p.152968-152968, Article 152968

2021

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Factor XIII cross-links fibrin(ogen) independent of fibrin polymerization in experimental acute liver injury

Blood, 2021-05, Vol.137 (18), p.2520-2531

2021

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Thrombin inhibition with dabigatran protects against high-fat diet-induced fatty liver disease in mice

The Journal of pharmacology and experimental therapeutics, 2014-11, Vol.351 (2), p.288

2014

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Coagulation in liver toxicity and disease: Role of hepatocyte tissue factor

Thrombosis research, 2014-05, Vol.133 (1), p.S57-S59

2014

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Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo

Toxicological sciences, 2018-04, Vol.162 (2), p.396-405

2018

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Plasminogen Activator Inhibitor-1 Reduces Tissue-Type Plasminogen Activator–Dependent Fibrinolysis and Intrahepatic Hemorrhage in Experimental Acetaminophen Overdose

The American journal of pathology, 2018-05, Vol.188 (5), p.1204-1212

2018

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Application of Immunocompetent Microphysiological Systems in Drug Development: Current Perspective and Recommendations

ALTEX, alternatives to animal experimentation, 2023-03, Vol.40 (2), p.314

2023

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Thrombin promotes diet-induced obesity through fibrin-driven inflammation

Intrahepatic fibrin(ogen) deposition drives liver regeneration after partial hepatectomy in mice and humans

A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice

Microphysiological systems in early stage drug development: Perspectives on current applications and future impact

Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury

Hepatocyte tissue factor activates the coagulation cascade in mice

Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium

The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury

Role of the blood coagulation cascade in hepatic fibrosis

Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water

Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice

Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice

Automated Dose-Response Analysis and Comparative Toxicogenomic Evaluation of the Hepatic Effects Elicited by TCDD, TCDF, and PCB126 in C57BL/6 Mice

PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: Comparative toxicogenomic effects of dioxin and non-dioxin-like ligands

Cross‐linking by tissue transglutaminase‐2 alters fibrinogen‐directed macrophage proinflammatory activity

Role of Fibrin(ogen) in Progression of Liver Disease: Guilt by Association?

Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of Mmp12

The Current Status and Use of Microphysiological Systems by the Pharmaceutical Industry: The International Consortium for Innovation and Quality Microphysiological Systems Affiliate Survey and Commentary

Von Willebrand factor exerts hepatoprotective effects in acute but not chronic cholestatic liver injury in mice

Factor XIII cross-links fibrin(ogen) independent of fibrin polymerization in experimental acute liver injury

Thrombin inhibition with dabigatran protects against high-fat diet-induced fatty liver disease in mice

Coagulation in liver toxicity and disease: Role of hepatocyte tissue factor

Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo

Plasminogen Activator Inhibitor-1 Reduces Tissue-Type Plasminogen Activator–Dependent Fibrinolysis and Intrahepatic Hemorrhage in Experimental Acetaminophen Overdose

Application of Immunocompetent Microphysiological Systems in Drug Development: Current Perspective and Recommendations

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