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Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells

Beilstein journal of organic chemistry, 2024-02, Vol.20 (1), p.445-451

2024

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Inhibition of efflux pumps aids small-molecule probe-based fluorescence labeling and imaging in the Gram-negative bacterium Escherichia coli

Organic & biomolecular chemistry, 2021-10, Vol.19 (41), p.8906-8911

2021

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Chemoproteomics profiling of surfactin-producing nonribosomal peptide synthetases in living bacterial cells

Cell chemical biology, 2022-01, Vol.29 (1), p.145-156.e8

2022

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Establishment of One-Pot Disulfide-Driven Cyclic Peptide Synthesis with a 3-Nitro-2-pyridinesulfenate

Chemical and Pharmaceutical Bulletin, 2023/06/01, Vol.71(6), pp.435-440

2023

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Functional profiling of adenylation domains in nonribosomal peptide synthetases by competitive activity-based protein profiling

Chemical communications (Cambridge, England), 2015-01, Vol.51 (87), p.15764-15767

2015

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Development of functionalized peptides for efficient inhibition of myostatin by selective photooxygenation

Organic & biomolecular chemistry, 2021-01, Vol.19 (1), p.199-27

2021

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Profiling Nonribosomal Peptide Synthetase Activities Using Chemical Proteomic Probes for Adenylation Domains

ACS chemical biology, 2015-09, Vol.10 (9), p.1989-1997

2015

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Structural Revision of Natural Cyclic Depsipeptide MA026 Established by Total Synthesis and Biosynthetic Gene Cluster Analysis

Angewandte Chemie International Edition, 2021-04, Vol.60 (16), p.8792-8797

International ed. in English, 2021

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Accurate Detection of Adenylation Domain Functions in Nonribosomal Peptide Synthetases by an Enzyme-linked Immunosorbent Assay System Using Active Site-directed Probes for Adenylation Domains

ACS chemical biology, 2015-12, Vol.10 (12), p.2816-2826

2015

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Active site-directed proteomic probes for adenylation domains in nonribosomal peptide synthetases

Chemical communications (Cambridge, England), 2015-02, Vol.51 (12), p.2262-2265

2015

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Inactivation of myostatin by photooxygenation using functionalized d-peptides

RSC medicinal chemistry, 2023-02, Vol.14 (2), p.386-392

2023

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A Chemoproteomics Approach to Investigate Phosphopantetheine Transferase Activity at the Cellular Level

Chembiochem : a European journal of chemical biology, 2017-09, Vol.18 (18), p.1855-1862

2017

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Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure–activity relationship study

European journal of medicinal chemistry, 2013-07, Vol.65, p.436-447

2013

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Probing for optimal photoaffinity linkers of benzophenone-based photoaffinity probes for adenylating enzymes

Bioorganic & medicinal chemistry, 2024-08, Vol.110, p.117815, Article 117815

2024

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Exploring a chemical scaffold for rapid and selective photoaffinity labelling of non-ribosomal peptide synthetases in living bacterial cells

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2023-02, Vol.378 (1871), p.20220026

2023

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Inhibition of efflux pumps aids small-molecule probe-based fluorescence labeling and imaging in the Gram-negative bacterium

Organic & biomolecular chemistry, 2021-10, Vol.19 (41), p.896-8911

2021

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3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV‑2 Agents

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.2926-2939

2022

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Chemical Synthesis of an HIV-1 Protease Analog with Some Amides in a Polypeptide Main Chain Replaced by Disulfide Bonds

Bulletin of the Chemical Society of Japan, 2022-08, Vol.95 (8), p.1156-1162

2022

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Peptide mixed phosphonates for covalent complex formation with thioesterases in nonribosomal peptide synthetases

Journal of peptide science, 2024-01, Vol.30 (1), p.e3532-n/a

2024

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X‑Ray Conformation and Structure–Activity Relationships of MA026, a Reversible Tight Junction Opener

Journal of medicinal chemistry, 2023-07, Vol.66 (13), p.8717-8724

2023

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Trapping the Complex Molecular Machinery of Polyketide and Fatty Acid Synthases with Tunable Silylcyanohydrin Crosslinkers

Angewandte Chemie International Edition, 2018-12, Vol.57 (52), p.17009-17013

International ed. in English, 2018

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Detection of Active SARS-CoV‑2 3CL Protease in Infected Cells Using Activity-Based Probes with a 2,6-Dichlorobenzoyloxymethyl Ketone Reactive Warhead

ACS chemical biology, 2024-05, Vol.19 (5), p.1028-1034

2024

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Development of Conformationally Restricted Negamycin Derivatives for Potent Readthrough Activity

ACS medicinal chemistry letters, 2023-12, Vol.14 (12), p.1807-1814

2023

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Functional profiling of adenylation domains in nonribosomal peptide synthetases by competitive activity-based protein profilingElectronic supplementary information (ESI) available: Supporting figures; procedures for the syntheses of aminoacyl-AMP analogs; complete gel images; full experimental details; and copies of 1H and 13C-NMR spectra. See DOI: 10.1039/c5cc04953a

2015-10

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Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies

European journal of medicinal chemistry, 2013-10, Vol.68, p.372-384

2013

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Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells

Inhibition of efflux pumps aids small-molecule probe-based fluorescence labeling and imaging in the Gram-negative bacterium Escherichia coli

Chemoproteomics profiling of surfactin-producing nonribosomal peptide synthetases in living bacterial cells

Establishment of One-Pot Disulfide-Driven Cyclic Peptide Synthesis with a 3-Nitro-2-pyridinesulfenate

Functional profiling of adenylation domains in nonribosomal peptide synthetases by competitive activity-based protein profiling

Development of functionalized peptides for efficient inhibition of myostatin by selective photooxygenation

Profiling Nonribosomal Peptide Synthetase Activities Using Chemical Proteomic Probes for Adenylation Domains

Structural Revision of Natural Cyclic Depsipeptide MA026 Established by Total Synthesis and Biosynthetic Gene Cluster Analysis

Accurate Detection of Adenylation Domain Functions in Nonribosomal Peptide Synthetases by an Enzyme-linked Immunosorbent Assay System Using Active Site-directed Probes for Adenylation Domains

Active site-directed proteomic probes for adenylation domains in nonribosomal peptide synthetases

Inactivation of myostatin by photooxygenation using functionalized d-peptides

A Chemoproteomics Approach to Investigate Phosphopantetheine Transferase Activity at the Cellular Level

Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure–activity relationship study

Probing for optimal photoaffinity linkers of benzophenone-based photoaffinity probes for adenylating enzymes

Exploring a chemical scaffold for rapid and selective photoaffinity labelling of non-ribosomal peptide synthetases in living bacterial cells

Inhibition of efflux pumps aids small-molecule probe-based fluorescence labeling and imaging in the Gram-negative bacterium

3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV‑2 Agents

Chemical Synthesis of an HIV-1 Protease Analog with Some Amides in a Polypeptide Main Chain Replaced by Disulfide Bonds

Peptide mixed phosphonates for covalent complex formation with thioesterases in nonribosomal peptide synthetases

X‑Ray Conformation and Structure–Activity Relationships of MA026, a Reversible Tight Junction Opener

Trapping the Complex Molecular Machinery of Polyketide and Fatty Acid Synthases with Tunable Silylcyanohydrin Crosslinkers

Detection of Active SARS-CoV‑2 3CL Protease in Infected Cells Using Activity-Based Probes with a 2,6-Dichlorobenzoyloxymethyl Ketone Reactive Warhead

Development of Conformationally Restricted Negamycin Derivatives for Potent Readthrough Activity

Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies

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