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5‑Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties

ACS medicinal chemistry letters, 2016-07, Vol.7 (7), p.666-670

2016

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Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394

ACS medicinal chemistry letters, 2016-07, Vol.7 (7), p.714-718

2016

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C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators

ACS medicinal chemistry letters, 2014-12, Vol.5 (12), p.1284-1289

2014

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Advances toward new antidepressants beyond SSRIS: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 4

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (10), p.2653-2656

2004

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Advances toward new antidepressants beyond SSRIs : 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 5

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (9), p.2347-2351

2006

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Advances toward new antidepressants beyond SSRIs: 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1

Bioorganic & medicinal chemistry letters, 2003-06, Vol.13 (11), p.1903-1905

2003

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Advances toward new antidepressants beyond SSRIS: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 3

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.3939-3942

2003

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Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 2

Bioorganic & medicinal chemistry letters, 2003-07, Vol.13 (14), p.2393-2397

2003

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Discovery of the imidazole-derived GPR40 agonist AM-3189

Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (1), p.15-20

2016

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Discovery and in Vivo Evaluation of Dual PI3Kβ/δ Inhibitors

Journal of medicinal chemistry, 2012-09, Vol.55 (17), p.7667-7685

2012

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Synthesis of benzimidazoles from 1,1-dibromoethenes

Tetrahedron letters, 2008-12, Vol.49 (51), p.7284-7286

2008

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Development of Dual-Acting Agents for Thromboxane Receptor Antagonism and Thromboxane Synthase Inhibition. 3. Synthesis and Biological Activities of Oxazolecarboxamide-Substituted ω-Phenyl-ω-(3-pyridyl)alkenoic Acid Derivatives and Related Compounds

Journal of medicinal chemistry, 1998-12, Vol.41 (27), p.5362-5374

1998

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Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents

Bioorganic & medicinal chemistry letters, 2008-02, Vol.18 (3), p.1037-1041

2008

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Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 2. Design, synthesis, and evaluation of a novel series of phenyl oxazole derivatives

Bioorganic & medicinal chemistry letters, 1998-08, Vol.8 (15), p.1943-1948

1998

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P3 cap modified Phe-Ala series BACE inhibitors

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.245-250

2004

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Discovery of potent LPA sub(2) (EDG4) antagonists as potential anticancer agents

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.1037-1041

2008

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Discovery of potent LPA 2 (EDG4) antagonists as potential anticancer agents

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (3), p.1037-1041

2008

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Stereoselectivity in the Wittig reaction of phenyl 3-pyridyl ketones: Amide substituent effect on the preferential (E)-ollefin formation

Tetrahedron letters, 1998-08, Vol.39 (32), p.5689-5692

1998

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Dibasic benzo[ b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 4. SAR studies on the conformationally restricted C3-side chain of hydroxybenzo[ b]thiophenes

Bioorganic & medicinal chemistry letters, 1999-03, Vol.9 (5), p.759-764

1999

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Advances toward new antidepressants beyond SSRIs: 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT 1A receptor antagonism/SSRI activities. Part 5

Bioorganic & medicinal chemistry letters, 2006, Vol.16 (9), p.2347-2351

2006

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Advances toward new antidepressants beyond SSRIs: 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT sub(1A) receptor antagonism/SSRI activities

Bioorganic & medicinal chemistry letters, 2006-01, Vol.16 (9), p.2347-2351

2006

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O1-06-02: The design and synthesis of an efficacious BACE inhibitor

Alzheimer's & dementia, 2006-07, Vol.2 (3), p.S20-S20

2006

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Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT 1A receptor antagonism/SSRI activities. Part 4

Bioorganic & medicinal chemistry letters, 2004, Vol.14 (10), p.2653-2656

2004

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5‑Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties

Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394

C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators

Advances toward new antidepressants beyond SSRIS: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 4

Advances toward new antidepressants beyond SSRIs : 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 5

Advances toward new antidepressants beyond SSRIs: 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1

Advances toward new antidepressants beyond SSRIS: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 3

Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 2

Dibasic Benzo[b]thiophene Derivatives as a Novel Class of Active Site-Directed Thrombin Inhibitors. 1. Determination of the Serine Protease Selectivity, Structure−Activity Relationships, and Binding Orientation

Discovery of the imidazole-derived GPR40 agonist AM-3189

Discovery and in Vivo Evaluation of Dual PI3Kβ/δ Inhibitors

Synthesis of benzimidazoles from 1,1-dibromoethenes

Development of Dual-Acting Agents for Thromboxane Receptor Antagonism and Thromboxane Synthase Inhibition. 3. Synthesis and Biological Activities of Oxazolecarboxamide-Substituted ω-Phenyl-ω-(3-pyridyl)alkenoic Acid Derivatives and Related Compounds

Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents

Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 2. Design, synthesis, and evaluation of a novel series of phenyl oxazole derivatives

P3 cap modified Phe-Ala series BACE inhibitors

Discovery of potent LPA sub(2) (EDG4) antagonists as potential anticancer agents

Discovery of potent LPA 2 (EDG4) antagonists as potential anticancer agents

Stereoselectivity in the Wittig reaction of phenyl 3-pyridyl ketones: Amide substituent effect on the preferential (E)-ollefin formation

Dibasic benzo[ b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 4. SAR studies on the conformationally restricted C3-side chain of hydroxybenzo[ b]thiophenes

Diamino Benzo[b]thiophene Derivatives as a Novel Class of Active Site Directed Thrombin Inhibitors. 5. Potency, Efficacy, and Pharmacokinetic Properties of Modified C-3 Side Chain Derivatives

Advances toward new antidepressants beyond SSRIs: 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT 1A receptor antagonism/SSRI activities. Part 5

Advances toward new antidepressants beyond SSRIs: 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT sub(1A) receptor antagonism/SSRI activities

O1-06-02: The design and synthesis of an efficacious BACE inhibitor

Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT 1A receptor antagonism/SSRI activities. Part 4

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