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The antibody-drug conjugate: an enabling modality for natural product-based cancer therapeutics

Natural product reports, 2013-01, Vol.3 (5), p.625-639

2013

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Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate-dependent dioxygenase

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (33), p.11921-11921

2014

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Discovery of the lomaiviticin biosynthetic gene cluster in Salinispora pacifica

Tetrahedron, 2014-07, Vol.70 (27-28), p.4156-4164

2014

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Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody–Drug Conjugates

Bioconjugate chemistry, 2019-01, Vol.30 (1), p.200-209

2019

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Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (12), p.4776-4781

2011

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Borrelidin B: Isolation, Biological Activity, and Implications for Nitrile Biosynthesis

Journal of natural products (Washington, D.C.), 2014-11, Vol.77 (11), p.2570-2574

2014

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Discovery and Assembly-Line Biosynthesis of the Lymphostin Pyrroloquinoline Alkaloid Family of mTOR Inhibitors in Salinispora Bacteria

Journal of the American Chemical Society, 2011-08, Vol.133 (34), p.13311-13313

2011

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The evolving role of natural products in drug discovery

Nature reviews. Drug discovery, 2005-02, Vol.4 (3), p.206-220

2005

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Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities

Proceedings of the National Academy of Sciences - PNAS, 2008-01, Vol.105 (1), p.33-38

2008

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Absolute Configurational Assignments of Secondary Amines by CD-Sensitive Dimeric Zinc Porphyrin Host

Journal of the American Chemical Society, 2002-09, Vol.124 (35), p.10320-10335

2002

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Amphotericin B, identified from a natural product screen, antagonizes CNS inhibitors to promote axon growth via activation of an Akt pathway in neurons

Journal of neurochemistry, 2010-06, Vol.113 (5), p.1331-1342

2010

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New Strategies and Methods in the Discovery of Natural Product Anti-Infective Agents: The Mannopeptimycins

Journal of medicinal chemistry, 2008-05, Vol.51 (9), p.2613-2617

Koehn, Frank E

2008

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Biosynthetic medicinal chemistry of natural product drugs

MedChemComm, 2012, Vol.3 (8), p.854

Koehn, Frank E.

2012

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Cytotoxic Spliceostatins from Burkholderia sp. and Their Semisynthetic Analogues

Journal of natural products (Washington, D.C.), 2014-08, Vol.77 (8), p.1864-1870

2014

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Biosynthetic engineering and fermentation media development leads to gram-scale production of spliceostatin natural products in Burkholderia sp

Metabolic engineering, 2016-01, Vol.33, p.67-75

2016

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Probing natural product biosynthetic pathways using Fourier transform ion cyclotron resonance mass spectrometry

Bioorganic & medicinal chemistry, 2009-03, Vol.17 (6), p.2154-2161

2009

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Synthesis of rapamycin glycoconjugates via a CuAAC-based approach

Tetrahedron letters, 2013-12, Vol.54 (51), p.6999-7003

2013

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6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases with Enhanced Antitumor Activity

Journal of medicinal chemistry, 2001-08, Vol.44 (17), p.2719-2734

2001

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Therapeutic potential of natural product signal transduction agents

Current opinion in biotechnology, 2006-12, Vol.17 (6), p.631-637

Koehn, Frank E

2006

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Chiral Recognition by CD-Sensitive Dimeric Zinc Porphyrin Host. 2. Structural Studies of Host−Guest Complexes with Chiral Alcohol and Monoamine Conjugates

Journal of the American Chemical Society, 2001-06, Vol.123 (25), p.5974-5982

2001

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Reassessing the Structure of Pyranonigrin

Journal of natural products (Washington, D.C.), 2007-07, Vol.70 (7), p.1180-1187

2007

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Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.279-282

2004

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Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibiotics

Bioorganic & medicinal chemistry letters, 2003-08, Vol.13 (16), p.2805-2808

2003

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The evolving role of natural products in drug discovery

Nature reviews. Drug discovery, 2005-03, Vol.4 (3), p.206-220

2005

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The antibody-drug conjugate: an enabling modality for natural product-based cancer therapeutics

Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate-dependent dioxygenase

Discovery of the lomaiviticin biosynthetic gene cluster in Salinispora pacifica

Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody–Drug Conjugates

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

Borrelidin B: Isolation, Biological Activity, and Implications for Nitrile Biosynthesis

Discovery and Assembly-Line Biosynthesis of the Lymphostin Pyrroloquinoline Alkaloid Family of mTOR Inhibitors in Salinispora Bacteria

The evolving role of natural products in drug discovery

Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities

Absolute Configurational Assignments of Secondary Amines by CD-Sensitive Dimeric Zinc Porphyrin Host

Diversity oriented biosynthesis via accelerated evolution of modular gene clusters

Amphotericin B, identified from a natural product screen, antagonizes CNS inhibitors to promote axon growth via activation of an Akt pathway in neurons

New Strategies and Methods in the Discovery of Natural Product Anti-Infective Agents: The Mannopeptimycins

Biosynthetic medicinal chemistry of natural product drugs

Cytotoxic Spliceostatins from Burkholderia sp. and Their Semisynthetic Analogues

Biosynthetic engineering and fermentation media development leads to gram-scale production of spliceostatin natural products in Burkholderia sp

Probing natural product biosynthetic pathways using Fourier transform ion cyclotron resonance mass spectrometry

Synthesis of rapamycin glycoconjugates via a CuAAC-based approach

6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases with Enhanced Antitumor Activity

Therapeutic potential of natural product signal transduction agents

Chiral Recognition by CD-Sensitive Dimeric Zinc Porphyrin Host. 2. Structural Studies of Host−Guest Complexes with Chiral Alcohol and Monoamine Conjugates

Reassessing the Structure of Pyranonigrin

Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria

Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibiotics

The evolving role of natural products in drug discovery

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