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Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954

Oncogene, 2001-11, Vol.20 (53), p.7797-7803

2001

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Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase

Oncogene, 2003-01, Vol.22 (3), p.370-380

2003

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Studies relating to the synthesis, enzymatic reduction and cytotoxicity of a series of nitroaromatic prodrugs

Bioorganic & medicinal chemistry letters, 2016-12, Vol.26 (24), p.5851-5854

2016

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Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs

Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (13), p.3986-3991

2011

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Functionalized Cyclopentadienyl Titanium Organometallic Compounds as New Antitumor Drugs

Organometallics, 2004-01, Vol.23 (2), p.288-292

2004

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Nitroreductase from Bacillus licheniformis: A stable enzyme for prodrug activation

Biochemical pharmacology, 2009, Vol.77 (1), p.21-29

2009

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Functionalised cyclopentadienyl zirconium compounds as potential anticancer drugs

Dalton transactions : an international journal of inorganic chemistry, 2008-10 (39), p.5293

2008

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Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: Effects of combining beneficial single mutations

Biochemical pharmacology, 2010-01, Vol.79 (2), p.102-111

2010

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The synthesis of 2-nitroaryl-1,2,3,4-tetrahydroisoquinolines, nitro-substituted 5,6-dihydrobenzimidazo[2,1- a]isoquinoline N-oxides and related heterocycles as potential bioreducible substrates for the enzymes NAD(P)H: quinone oxidoreductase 1 and E. coli nitroreductase

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7447-7450

2011

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Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs

Dalton transactions : an international journal of inorganic chemistry, 2007-01 (43), p.5082-5090

2007

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Design, Synthesis, and Biological Evaluation of Cyclic and Acyclic Nitrobenzylphosphoramide Mustards for E. coli Nitroreductase Activation

Journal of medicinal chemistry, 2006-07, Vol.49 (14), p.4333-4343

2006

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Quinone Reductase–Mediated Nitro-Reduction: Clinical Applications

Methods in Enzymology, 2004, Vol.382, p.194-221

2004

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Nitroaryl Phosphoramides as Novel Prodrugs for E. coli Nitroreductase Activation in Enzyme Prodrug Therapy

Journal of medicinal chemistry, 2003-11, Vol.46 (23), p.4818-4821

2003

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KW-2149 (7- N-[2-[γ- l-glutamylamino]ethyldithio-ethyl] mitomycin C): DNA Interactions and Drug Uptake Following Serum Activation

Biochemical pharmacology, 1998-06, Vol.55 (11), p.1777-1783

1998

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Design, Synthesis, and Biological Evaluation of Cyclic and Acyclic Nitrobenzylphosphoramide Mustards for E. c oli Nitroreductase Activation

Journal of medicinal chemistry, 2006-07, Vol.49 (14), p.4333-4343

2006

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Developments with targeted enzymes in cancer therapy

Current Opinion in Immunology, 1999-10, Vol.11 (5), p.579-583

1999

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Involvement of NADPH: cytochrome P450 reductase in the activation of indoloquinone EO9 to free radical and DNA damaging species

Biochemical pharmacology, 2001-08, Vol.62 (4), p.461-468

2001

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Mechanism of cytotoxicity of anticancer platinum drugs: evidence that cis-diamminedichloroplatinum (II) and cis-diammine-(1,1-cyclobutanedicarboxylato)platinum(II) differ only in the kinetics of their interaction with DNA

Cancer research (Chicago, Ill.), 1986-04, Vol.46 (4), p.1972-1979

1986

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Self-Immolative Prodrugs: Candidates for Antibody-Directed Enzyme Prodrug Therapy in Conjunction with a Nitroreductase Enzyme

Journal of medicinal chemistry, 1994-10, Vol.37 (21), p.3452-3458

1994

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Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites

Biochemical pharmacology, 1998-09, Vol.56 (5), p.613-621

1998

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Synthesis of 2-aryl-6-methyl-5-nitroquinoline derivatives as potential prodrug systems for reductive activation

Tetrahedron, 2008-03, Vol.64 (12), p.2816-2823

2008

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Phthalimide analogs of CB 1954: synthesis and bioactivation

Anti-cancer drugs, 1999-09, Vol.10 (8), p.777-784

1999

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Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2 : A novel co-substrate-mediated antitumor prodrug therapy

Cancer research (Chicago, Ill.), 2000-08, Vol.60 (15), p.4179-4186

2000

Volltextzugriff (PDF)

An unexpected ring contraction of two nitroaryl pro-drugs: conversion of N-(nitroaryl)-3-chloropiperidine derivatives into N-(nitroaryl)-2-chloromethylpyrrolidines

Tetrahedron letters, 2010-07, Vol.51 (30), p.3918-3921

2010

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CB 1954: from the Walker tumor to NQO2 and VDEPT

Current pharmaceutical design, 2003-10, Vol.9 (26), p.2091

2003

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Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954

Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase

Studies relating to the synthesis, enzymatic reduction and cytotoxicity of a series of nitroaromatic prodrugs

Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs

Functionalized Cyclopentadienyl Titanium Organometallic Compounds as New Antitumor Drugs

Nitroreductase from Bacillus licheniformis: A stable enzyme for prodrug activation

Functionalised cyclopentadienyl zirconium compounds as potential anticancer drugs

Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: Effects of combining beneficial single mutations

The synthesis of 2-nitroaryl-1,2,3,4-tetrahydroisoquinolines, nitro-substituted 5,6-dihydrobenzimidazo[2,1- a]isoquinoline N-oxides and related heterocycles as potential bioreducible substrates for the enzymes NAD(P)H: quinone oxidoreductase 1 and E. coli nitroreductase

Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs

Design, Synthesis, and Biological Evaluation of Cyclic and Acyclic Nitrobenzylphosphoramide Mustards for E. coli Nitroreductase Activation

Quinone Reductase–Mediated Nitro-Reduction: Clinical Applications

Nitroaryl Phosphoramides as Novel Prodrugs for E. coli Nitroreductase Activation in Enzyme Prodrug Therapy

KW-2149 (7- N-[2-[γ- l-glutamylamino]ethyldithio-ethyl] mitomycin C): DNA Interactions and Drug Uptake Following Serum Activation

Design, Synthesis, and Biological Evaluation of Cyclic and Acyclic Nitrobenzylphosphoramide Mustards for E. c oli Nitroreductase Activation

Developments with targeted enzymes in cancer therapy

Involvement of NADPH: cytochrome P450 reductase in the activation of indoloquinone EO9 to free radical and DNA damaging species

Mechanism of cytotoxicity of anticancer platinum drugs: evidence that cis-diamminedichloroplatinum (II) and cis-diammine-(1,1-cyclobutanedicarboxylato)platinum(II) differ only in the kinetics of their interaction with DNA

Self-Immolative Prodrugs: Candidates for Antibody-Directed Enzyme Prodrug Therapy in Conjunction with a Nitroreductase Enzyme

Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites

Synthesis of 2-aryl-6-methyl-5-nitroquinoline derivatives as potential prodrug systems for reductive activation

Phthalimide analogs of CB 1954: synthesis and bioactivation

Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2 : A novel co-substrate-mediated antitumor prodrug therapy

An unexpected ring contraction of two nitroaryl pro-drugs: conversion of N-(nitroaryl)-3-chloropiperidine derivatives into N-(nitroaryl)-2-chloromethylpyrrolidines

CB 1954: from the Walker tumor to NQO2 and VDEPT

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